282 research outputs found
Comparison of stimulation patterns for FES-cycling using measures of oxygen cost and stimulation cost
<b>Aim</b><p></p>
The energy efficiency of FES-cycling in spinal cord injured subjects is very much lower than that of normal cycling, and efficiency is dependent upon the parameters of muscle stimulation. We investigated measures which can be used to evaluate the effect on cycling performance of changes in stimulation parameters, and which might therefore be used to optimise them. We aimed to determine whether oxygen cost and stimulation cost measurements are sensitive enough to allow discrimination between the efficacy of different activation ranges for stimulation of each muscle group during constant-power cycling. <p></p>
<b>Methods</b><p></p>
We employed a custom FES-cycling ergometer system, with accurate control of cadence and stimulated exercise workrate. Two sets of muscle activation angles (“stimulation patterns”), denoted “P1” and “P2”, were applied repeatedly (eight times each) during constant-power cycling, in a repeated measures design with a single paraplegic subject. Pulmonary oxygen uptake was measured in real time and used to determine the oxygen cost of the exercise. A new measure of stimulation cost of the exercise is proposed, which represents the total rate of stimulation charge applied to the stimulated muscle groups during cycling. A number of energy-efficiency measures were also estimated. <p></p>
<b>Results</b><p></p>
Average oxygen cost and stimulation cost of P1 were found to be significantly lower than those for P2 (paired <i>t</i>-test, <i>p</i> < 0.05): oxygen costs were 0.56 ± 0.03 l min<sup>−1</sup> and 0.61 ± 0.04 l min<sup>−1</sup>(mean ± S.D.), respectively; stimulation costs were 74.91 ± 12.15 mC min<sup>−1</sup> and 100.30 ± 14.78 mC min<sup>−1</sup> (mean ± S.D.), respectively. Correspondingly, all efficiency estimates for P1 were greater than those for P2. <p></p>
<b>Conclusion</b><p></p>
Oxygen cost and stimulation cost measures both allow discrimination between the efficacy of different muscle activation patterns during constant-power FES-cycling. However, stimulation cost is more easily determined in real time, and responds more rapidly and with greatly improved signal-to-noise properties than the ventilatory oxygen uptake measurements required for estimation of oxygen cost. These measures may find utility in the adjustment of stimulation patterns for achievement of optimal cycling performance. <p></p>
Towards a New Standard Model for Black Hole Accretion
We briefly review recent developments in black hole accretion disk theory,
emphasizing the vital role played by magnetohydrodynamic (MHD) stresses in
transporting angular momentum. The apparent universality of accretion-related
outflow phenomena is a strong indicator that large-scale MHD torques facilitate
vertical transport of angular momentum. This leads to an enhanced overall rate
of angular momentum transport and allows accretion of matter to proceed at an
interesting rate. Furthermore, we argue that when vertical transport is
important, the radial structure of the accretion disk is modified at small
radii and this affects the disk emission spectrum. We present a simple model
demonstrating how energetic, magnetically-driven outflows modify the emergent
disk emission spectrum with respect to that predicted by standard accretion
disk theory. A comparison of the predicted spectra against observations of
quasar spectral energy distributions suggests that mass accretion rates
inferred using the standard disk model may severely underestimate their true
values.Comment: To appear in the Fifth Stromlo Symposium Proceedings special issue of
ApS
Universal structure of the edge states of the fractional quantum Hall states
We present an effective theory for the bulk fractional quantum Hall states on
the Jain sequences on closed surfaces and show that it has a universal form
whose structure does not change from fraction to fraction. The structure of
this effective theory follows from the condition of global consistency of the
flux attachment transformation on closed surfaces. We derive the theory of the
edge states on a disk that follows naturally from this globally consistent
theory on a torus. We find that, for a fully polarized two-dimensional electron
gas, the edge states for all the Jain filling fractions have
only one propagating edge field that carries both energy and charge, and two
non-propagating edge fields of topological origin that are responsible for the
statistics of the excitations. Explicit results are derived for the electron
and quasiparticle operators and for their propagators at the edge. We show that
these operators create states with the correct charge and statistics. It is
found that the tunneling density of states for all the Jain states scales with
frequency as .Comment: 10 page
Edge magnetoplasmons in periodically modulated structures
We present a microscopic treatment of edge magnetoplasmons (EMP's) within the
random-phase approximation for strong magnetic fields, low temperatures, and
filling factor , when a weak short-period superlattice potential is
imposed along the Hall bar. The modulation potential modifies both the spatial
structure and the dispersion relation of the fundamental EMP and leads to the
appearance of a novel gapless mode of the fundamental EMP. For sufficiently
weak modulation strengths the phase velocity of this novel mode is almost the
same as the group velocity of the edge states but it should be quite smaller
for stronger modulation. We discuss in detail the spatial structure of the
charge density of the renormalized and the novel fundamental EMP's.Comment: 8 pages, 4 figure
Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART
The precise role of CD4 T cell turnover in maintaining HIV persistence during antiretroviral therapy (ART) has not yet been well characterized. In resting CD4 T cell subpopulations from 24 HIV-infected ART-suppressed and 6 HIV-uninfected individuals, we directly measured cellular turnover by heavy water labeling, HIV reservoir size by integrated HIV-DNA (intDNA) and cell-associated HIV-RNA (caRNA), and HIV reservoir clonality by proviral integration site sequencing. Compared to HIV-negatives, ART-suppressed individuals had similar fractional replacement rates in all subpopulations, but lower absolute proliferation rates of all subpopulations other than effector memory (TEM) cells, and lower plasma IL-7 levels (p = 0.0004). Median CD4 T cell half-lives decreased with cell differentiation from naïve to TEM cells (3 years to 3 months, p<0.001). TEM had the fastest replacement rates, were most highly enriched for intDNA and caRNA, and contained the most clonal proviral expansion. Clonal proviruses detected in less mature subpopulations were more expanded in TEM, suggesting that they were maintained through cell differentiation. Earlier ART initiation was associated with lower levels of intDNA, caRNA and fractional replacement rates. In conclusion, circulating integrated HIV proviruses appear to be maintained both by slow turnover of immature CD4 subpopulations, and by clonal expansion as well as cell differentiation into effector cells with faster replacement rates
Production and Decay of D_1(2420)^0 and D_2^*(2460)^0
We have investigated and final states and
observed the two established charmed mesons, the with mass
MeV/c and width MeV/c and
the with mass MeV/c and width
MeV/c. Properties of these final states, including
their decay angular distributions and spin-parity assignments, have been
studied. We identify these two mesons as the doublet predicted
by HQET. We also obtain constraints on {\footnotesize } as a function of the cosine of the relative phase of the two
amplitudes in the decay.Comment: 15 pages in REVTEX format. hardcopies with figures can be obtained by
sending mail to: [email protected]
Measurement of the branching fraction for
We have studied the leptonic decay of the resonance into tau
pairs using the CLEO II detector. A clean sample of tau pair events is
identified via events containing two charged particles where exactly one of the
particles is an identified electron. We find . The result is consistent with
expectations from lepton universality.Comment: 9 pages, RevTeX, two Postscript figures available upon request, CLNS
94/1297, CLEO 94-20 (submitted to Physics Letters B
Study of the B^0 Semileptonic Decay Spectrum at the Upsilon(4S) Resonance
We have made a first measurement of the lepton momentum spectrum in a sample
of events enriched in neutral B's through a partial reconstruction of B0 -->
D*- l+ nu. This spectrum, measured with 2.38 fb**-1 of data collected at the
Upsilon(4S) resonance by the CLEO II detector, is compared directly to the
inclusive lepton spectrum from all Upsilon(4S) events in the same data set.
These two spectra are consistent with having the same shape above 1.5 GeV/c.
From the two spectra and two other CLEO measurements, we obtain the B0 and B+
semileptonic branching fractions, b0 and b+, their ratio, and the production
ratio f+-/f00 of B+ and B0 pairs at the Upsilon(4S). We report b+/b0=0.950
(+0.117-0.080) +- 0.091, b0 = (10.78 +- 0.60 +- 0.69)%, and b+ = (10.25 +- 0.57
+- 0.65)%. b+/b0 is equivalent to the ratio of charged to neutral B lifetimes,
tau+/tau0.Comment: 14 page, postscript file also available at
http://w4.lns.cornell.edu/public/CLN
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