Berger Memorial : a Jewish funeral home

Project (B. Arch.)--University of Kansas, Architecture and Urban Design, 1969

Future therapeutic targets in rheumatoid arthritis?

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint inflammation. Without adequate treatment, patients with RA will develop joint deformity and progressive functional impairment. With the implementation of treat-to-target strategies and availability of biologic therapies, the outcomes for patients with RA have significantly improved. However, the unmet need in the treatment of RA remains high as some patients do not respond sufficiently to the currently available agents, remission is not always achieved and refractory disease is not uncommon. With better understanding of the pathophysiology of RA, new therapeutic approaches are emerging. Apart from more selective Janus kinase inhibition, there is a great interest in the granulocyte macrophage-colony stimulating factor pathway, Bruton's tyrosine kinase pathway, phosphoinositide-3-kinase pathway, neural stimulation and dendritic cell-based therapeutics. In this review, we will discuss the therapeutic potential of these novel approaches

Marketing hospitality industry in an era of crisis

The article examines and evaluates Greek hotels’ marketing strategies during recession. It focuses on the investigation of hospitality practices during crisis, marketing strategies and innovation, development of competitive advantage, use of IT for marketing, and the influential links between them. It also examines the impacts of accommodation category and geographical type of hotel. The research is based on a nationwide e-mail survey to hospitality managers/owners (N=914). The results reveal the significant effort put into production cost minimisation, the direct effect of this on marketing strategies, the strong enterprising focus on marketing innovation, and the impact of the use of IT for marketing purposes, whilst the accommodation category has a greater impact on the examined constructs than does geographical type. The conceptualisation adopted provides recommendations for hospitality owners and managers along with a better understanding of the aspects contributing to hospitality marketing in a period of recession and political instability

Cell Blebbing and Membrane Area Homeostasis in Spreading and Retracting Cells

Cells remodel their plasma membrane and cytoskeleton during numerous physiological processes, including spreading and motility. Morphological changes require the cell to adjust its membrane tension on different timescales. While it is known that endo- and exocytosis regulate the cell membrane area in a timescale of 1 h, faster processes, such as abrupt cell detachment, require faster regulation of the plasma membrane tension. In this article, we demonstrate that cell blebbing plays a critical role in the global mechanical homeostasis of the cell through regulation of membrane tension. Abrupt cell detachment leads to pronounced blebbing (which slow detachment does not), and blebbing decreases with time in a dynamin-dependent fashion. Cells only start spreading after a lag period whose duration depends on the cell's blebbing activity. Our model quantitatively reproduces the monotonic decay of the blebbing activity and accounts for the lag phase in the spreading of blebbing cells