Expression of TLR1-10 and caspase-3 alfa at women with early miscarriages

Toll-like receptors (TLR) are the first signal receptors of innate immunity, recognizing bacteria and viruses and promoting development of inflammation through the activation of proinflammatory cytokines secretion (1). In animal models it was shown, that TLRs play role in pathogenesis of miscarriages (2, 3) and can influence to trophoblast apoptosis. The aim of research was to investigate study specialty of mRNA expression of TLR1-10 and caspase-3a in endometrium at patients with early miscarriagesyesBelgorod State Universit

Can TLR3 influence to p53 and p63 apoptosis pathways in early miscarriages?

Objective - to define the role of TLR3 in activation of p53 and p63 apoptotic pathways in patients with early miscarriage

ОПЫТ ПРИМЕНЕНИЯ ГИПОТЕРМИИ ВОЛОСИСТОЙ ЧАСТИ КОЖИ ГОЛОВЫ ДЛЯ ПРОФИЛАКТИКИ АЛОПЕЦИИ ПРИ ПРОВЕДЕНИИ ХИМИОТЕРАПИИ

Short-term results of using Orbis II Paxman device for prevention of chemotherapy-induced alopecia were analyzed. A total of 98 sessions of scalp cooling were performed in 32 patients.  Twenty-four (80 %) scalpcooled patients had good hair preservation. The level of comfort during the procedure was 87 %. Patients with breast cancer underwent 55 scalp cooling sessions.  Good hair preservation was observed in 88% of cases. Grade 1 and 2 alopecia was observed in 12% of patients.  Thus, the data obtained confirm that the use of scalp cooling methods can improve the quality of life for patients receiving chemotherapy.Представлены непосредственные результаты использования аппарата Orbis II Paxman для профилактики алопеции при проведении системной химиотерапии. Было проведено 98 сеансов локальной гипотермии волосистой части головы у 32 пациентов. У 24 человек (80 %) волосы сохранены в полном объеме. Уровень комфортности при проведении процедуры составил 87 %. Чаще всего гипотермия проводилась пациентам с диагнозом рак молочной железы – 55 сеансов. В 88 % случаев волосы сохранены в полном объеме, у 12 % отмечалась алопеция I и II степени. Использование методики охлаждения волосистой части кожи головы улучшает качество жизни пациентов

Анализ ключевых компонентов реабилитационного диагноза у пациентов с инсультом в острейшую фазу

Introduction. There are key problems that limit patients’ functioning in the period after insult. The content of these problems determines the structure of multidisciplinary team.The objective of the study was to describe key problems that limited patients’ functioning in the period after insult and determine the structure of multidisciplinary team for resolving these problems efficiently.Material and methods. The study was observational. The sample size was 81 patients. Inclusion criteria: acute phase of post ischemic or hemorrhagic stroke (0–14 days after onset), mRs score 2 and more at admission to the hospital, the age over 18 years. Exclusion criteria: patients with transient ischemic attack, subarachnoid haemorrhage, Glasgow coma scale 2 and more at admission to the hospital. All patients – research participants received medical care in according to clinical guidelines, and multidisciplinary rehabilitation. In the course of rehabilitation, the first and second key problems that limited patients’ functioning in the period after insult were dedicated in each patient. We also investigated these problems and explored, which specialists must have been included in the structure of multidisciplinary team.Results. The key problems were non-medical in 24 % cases, poor exercise capacity were presented in 27 % cases, environment issues – 6 % cases, swallowing and speech disorders – 17 %, nursery problems – 4 %. The next specialists were needed to resolve the key problems: psychologist – 38 % cases, physical therapist– 69 % cases, occupational therapist – 28 % cases, neurologist – 27 % cases, physical medicine and rehabilitation physician – 27 % cases.Conclusion. Medical (rehabilitation physician, specialist, nurse) and non-medical specialists (occupational therapist, physical therapist, psychologist, logopaedist, etc.) must have been included in multidisciplinary team.Введение. У пациентов с инсультом в реабилитационном периоде обнаруживаются ключевые проблемы, ограничивающие функционирование. Характер ключевых проблем определяет потребность определенных специалистов в составе мультидисциплинарной бригады (МДБ).Цель исследования. Описать ключевые проблемы, ограничивающие функционирование пациентов с инсультом и определить какие специалисты должны входить в состав МДБ.Материалы и методы. Исследование наблюдательное. Размер выборки 81 человек. В выборку включены пациенты в острейшем периоде ишемического или геморрагического инсульта, с оценкой по модифицированной шкале Рэнкина 2 и более балла при поступлении в стационар, возрастом старше 18 лет. В выборку намерено не включались пациенты с изолированной транзиторной ишемической атакой, изолированным субарахноидальным кровоизлиянием, с уровнем сознания при поступлении кома 2 и более. Пациентам – участникам исследования оказана медицинская помощь в соответствии с имеющимися рекомендациями, проведена мультидисциплинарная реабилитация. В ходе реабилитации у каждого пациента выделены первая и вторая ключевая проблемы, ограничивающие функционирование.Результаты. Ключевые проблемы носили немедицинский характер в 24% случаев, снижение толерантности к физической нагрузке – 27% случаев, проблемы со средой – 6% случаев, нарушения глотания и речи – 17% случаев, проблемы сестринского характера – 4% случаев. Для решения ключевых проблем требовалось участие психолога в 38% случаев, физического терапевта – в 69% случаев, эрготерапевта – в 28% случаев, невролога – в 27% случаев, врача-реабилитолога – в 27% случаев.Заключение. В состав мультидисциплинарной бригады должны входить специалисты медицинского (врач-реабилитолог, профильный специалист, медицинская сестра) и немедицинского профиля (эрготерапевт, физический терапевт, психолог, логопед, и др.)

Sociological Analysis of Employment of Student’s Youth

The article contains the results of a pilot study on the peculiarities of employment of Russian students. The author pays special attention to the pros and cons of combining student learning with work, actualizes the increasing role of secondary employment in the process of professional development of young people.Статья содержит результаты пилотного исследования об особенностях трудовой занятости российских студентов. Автор обращает особое внимание на плюсы и минусы совмещения студентами обучения с работой, актуализирует возрастающую роль вторичной занятости в процессе профессионального становления молодежи

The Economic Opportunities of Students: Assistance, Support, or Employment Income?

The article searches for the answer to the question about the economic opportunities of modern students, their preferred sources of income (assistance of the parent family and the state, support of private, public organizations and state structures, as well as personal labor income).В статье осуществлен поиск ответа на вопрос об экономических возможностях современных студентов, предпочитаемых ими источниках доходов (помощь родительской семьи и государства, поддержка частных, общественных организаций и государственных структур, а также личного трудового дохода)

Can TLR3 influence to p53 and p63 apoptosis pathways in early miscarriages?

Objective - to define the role of TLR3 in activation of p53 and p63 apoptotic pathways in patients with early miscarriage

EXPERIENCE OF SCALP COOLING FOR PREVENTION CHEMOTHERAPY-INDUCED HAIR LOSS

Short-term results of using Orbis II Paxman device for prevention of chemotherapy-induced alopecia were analyzed. A total of 98 sessions of scalp cooling were performed in 32 patients.  Twenty-four (80 %) scalpcooled patients had good hair preservation. The level of comfort during the procedure was 87 %. Patients with breast cancer underwent 55 scalp cooling sessions.  Good hair preservation was observed in 88% of cases. Grade 1 and 2 alopecia was observed in 12% of patients.  Thus, the data obtained confirm that the use of scalp cooling methods can improve the quality of life for patients receiving chemotherapy

Тне intranatal causes of grave condition at premature newborns

In this article we present statistic analysis of delivery tactic in premature labors. The newborns of those mothers who took the tocolitical therapy and prevention of RDS were needed in artificial pulmonary ventilation accordingly in 3,3-5,0 and twice times rarer

Analysis of key components in the rehabilitation diagnosis of acute stroke patients

Introduction. There are key problems that limit patients’ functioning in the period after insult. The content of these problems determines the structure of multidisciplinary team.The objective of the study was to describe key problems that limited patients’ functioning in the period after insult and determine the structure of multidisciplinary team for resolving these problems efficiently.Material and methods. The study was observational. The sample size was 81 patients. Inclusion criteria: acute phase of post ischemic or hemorrhagic stroke (0–14 days after onset), mRs score 2 and more at admission to the hospital, the age over 18 years. Exclusion criteria: patients with transient ischemic attack, subarachnoid haemorrhage, Glasgow coma scale 2 and more at admission to the hospital. All patients – research participants received medical care in according to clinical guidelines, and multidisciplinary rehabilitation. In the course of rehabilitation, the first and second key problems that limited patients’ functioning in the period after insult were dedicated in each patient. We also investigated these problems and explored, which specialists must have been included in the structure of multidisciplinary team.Results. The key problems were non-medical in 24 % cases, poor exercise capacity were presented in 27 % cases, environment issues – 6 % cases, swallowing and speech disorders – 17 %, nursery problems – 4 %. The next specialists were needed to resolve the key problems: psychologist – 38 % cases, physical therapist– 69 % cases, occupational therapist – 28 % cases, neurologist – 27 % cases, physical medicine and rehabilitation physician – 27 % cases.Conclusion. Medical (rehabilitation physician, specialist, nurse) and non-medical specialists (occupational therapist, physical therapist, psychologist, logopaedist, etc.) must have been included in multidisciplinary team