413 research outputs found
Assessing Primary Care Physician’s Beliefs and Attitudes of Asthma Exacerbation Treatment and Follow-Up
SPICES II. Optical and Near-Infrared Identifications of Faint X-Ray Sources from Deep Chandra Observations of Lynx
We present our first results on field X-ray sources detected in a deep, 184.7
ks observation with the ACIS-I camera on Chandra. The observations target the
Lynx field of SPICES, and contains three known X-ray-emitting clusters out to
z=1.27. Not including the known clusters, in the 17'x17' ACIS-I field we detect
132 sources in the 0.5-2 keV (soft) X-ray band down to a limiting flux of
\~1.7e-16 erg/cm2/s and 111 sources in the 2-10 keV (hard) X-ray band down to a
limiting flux of ~1.3e-15 erg/cm2/s. The combined catalog contains a total of
153 sources, of which 42 are detected only in the soft band and 21 are detected
only in the hard band. Confirming previous Chandra results, we find that the
fainter sources have harder X-ray spectra, providing a consistent solution to
the long-standing `spectral paradox'. From deep optical and near-infrared
follow-up data, 77% of the X-ray sources have optical counterparts to I=24 and
71% of the X-ray sources have near-infrared counterparts to K=20. Four of the
24 sources in the near-IR field are associated with extremely red objects
(EROs; I-K>4). We have obtained spectroscopic redshifts with the Keck
telescopes of 18 of the Lynx Chandra sources. These sources comprise a mix of
broad-lined active galaxies, apparently normal galaxies, and two late-type
Galactic dwarfs. Intriguingly, one Galactic source is identified with an M7
dwarf exhibiting non-transient, hard X-ray emission. We review non-AGN
mechanisms to produce X-ray emission and discuss properties of the Lynx Chandra
sample in relation to other samples of X-ray and non-X-ray sources.Comment: 42 pages, 16 figures. Accepted for publication in the May 2002
Astronomical Journa
Discovery of a Radio-Selected z ~ 6 Quasar
We present the discovery of only the second radio-selected, z ~ 6 quasar. We
identified SDSS J222843.54+011032.2 (z=5.95) by matching the optical detections
of the deep Sloan Digital Sky Survey (SDSS) Stripe 82 with their radio
counterparts in the Stripe82 VLA Survey. We also matched the
Canadian-France-Hawaiian Telescope Legacy Survey Wide (CFHTLS Wide) with the
Faint Images of the Radio Sky at Twenty-cm (FIRST) survey but have yet to find
any z ~ 6 quasars in this survey area. The discovered quasar is
optically-faint, z = 22.3 and M_{1450} ~ -24.5, but radio-bright, with a flux
density of f = 0.31mJy and a radio-loudness of R ~ 1100 (where
R = f_{5GHz}/f_{2500}). The i-z color of the discovered quasar places it
outside the color selection criteria for existing optical surveys. We conclude
by discussing the need for deeper wide-area radio surveys in the context of
high-redshift quasars.Comment: 20 pages, 6 figures, and ApJ accepte
An IR-Selected Galaxy Cluster at z = 1.41
We report the discovery of a galaxy cluster at z = 1.41. ISCS J143809+341419
was found in the Spitzer/IRAC Shallow Survey of the Bootes field in the NOAO
Deep Wide-Field Survey carried out by IRAC. The cluster candidate was initially
identified as a high density region of objects with photometric redshifts in
the range 1.3 < z < 1.5. Optical spectroscopy of a limited number of objects in
the region shows that 5 galaxies within a ~120 arcsec diameter region lie at z
= 1.41 +/- 0.01. Most of these member galaxies have broad--band colors
consistent with the expected spectral energy distribution of a
passively--evolving elliptical galaxy formed at high redshift. The redshift of
ISCS J143809+341419 is the highest currently known for a
spectroscopically-confirmed cluster of galaxies.Comment: Accepted for publication in The Astrophysical Journal Letters; 5
pages and 5 figure
Autoantibodies against retinal proteins in paraneoplastic and autoimmune retinopathy
BACKGROUND: Autoimmune retinal degeneration may occur in patients who present with sudden or, less commonly, subacute loss of vision of retinal origin, associated with an abnormal ERG, through the action of autoantibodies against retinal proteins. Often the patients are initially diagnosed with or suspected of having a paraneoplastic retinopathy (PR), such as cancer-associated retinopathy (CAR). However, there is limited information on the occurrence, the specificity of autoantibodies in these patients, and their association with clinical symptoms. METHODS: Sera were obtained from 193 retinopathy patients who presented with clinical symptoms resembling PR or autoimmune retinopathy (AR), including sudden painless loss of vision, typically associated with visual field defects and photopsias, and abnormal rod and/or cone responses on the electroretinogram (ERG). Sera were tested for the presence of anti-retinal autoantibodies by Western blot analysis using proteins extracted from human retina and by immunohistochemistry. Autoantibody titers against recoverin and enolase were measured by ELISA. RESULTS: We identified a higher prevalence of anti-retinal autoantibodies in retinopathy patients. Ninety-one patients' sera (47.1%) showed autoantibodies of various specificities with a higher incidence of antibodies present in retinopathy patients diagnosed with cancer (33/52; 63.5%; p = 0.009) than in retinopathy patients without cancer (58/141; 41.1%). The average age of PR patients was 62.0 years, and that of AR patients was 55.9 years. Autoantibodies against recoverin (p23) were only present in the sera of PR patients, autoantibodies against unknown p35 were more common in patients with AR, while anti-enolase (anti-p46) autoantibodies were nearly equally distributed in the sera of patients with PR and those with AR. In the seropositive patients, the autoantibodies persisted over a long period of time – from months to years. A rebound in anti-recoverin autoantibody titer was found to be associated with exacerbations in visual symptoms but not in the recurrence of cancer. When compared to sera from healthy subjects, autoantibodies against retinal proteins from both groups of patients were cytotoxic to retinal cells, indicating their pathogenic potential. CONCLUSIONS: These studies showed that patients with sudden or subacute, unexplained loss of vision of retinal origin have anti-retinal antibodies in a broad range of specificity and indicate the need for autoantibody screening. Follow-up tests of antibody levels may be useful as a biomarker of disease activity associated with worsening of vision. Moreover, the heterogeneity in autoantibody specificity may explain the variation and complexity of clinical symptoms in retinopathy patients
The Unusual Infrared Object HDF-N J123656.3+621322
We describe an object in the Hubble Deep Field North with very unusual
near-infrared properties. It is readily visible in Hubble Space Telescope
NICMOS images at 1.6um and from the ground at 2.2um, but is undetected (with
signal-to-noise <~ 2) in very deep WFPC2 and NICMOS data from 0.3 to 1.1um. The
f_nu flux density drops by a factor >~ 8.3 (97.7% confidence) from 1.6 to
1.1um. The object is compact but may be slightly resolved in the NICMOS 1.6um
image. In a low-resolution, near-infrared spectrogram, we find a possible
emission line at 1.643um, but a reobservation at higher spectral resolution
failed to confirm the line, leaving its reality in doubt. We consider various
hypotheses for the nature of this object. Its colors are unlike those of known
galactic stars, except perhaps the most extreme carbon stars or Mira variables
with thick circumstellar dust shells. It does not appear to be possible to
explain its spectral energy distribution as that of a normal galaxy at any
redshift without additional opacity from either dust or intergalactic neutral
hydrogen. The colors can be matched by those of a dusty galaxy at z >~ 2, by a
maximally old elliptical galaxy at z >~ 3 (perhaps with some additional
reddening), or by an object at z >~ 10 whose optical and 1.1um light have been
suppressed by the intergalactic medium. Under the latter hypothesis, if the
luminosity results from stars and not an AGN, the object would resemble a
classical, unobscured protogalaxy, with a star formation rate >~ 100 M_sun/yr.
Such UV-bright objects are evidently rare at 2 < z < 12.5, however, with a
space density several hundred times lower than that of present-day L* galaxies.Comment: Accepted for publication in the Astrophysical Journal. 27 pages,
LaTeX, with 7 figures (8 files); citations & references updated + minor
format change
Poor outcome of revised resurfacing hip arthroplasty: 397 cases from the Australian Joint Replacement Registry
BACKGROUND AND PURPOSE: Recent years have seen a rapid increase in the use of resurfacing hip arthroplasty despite the lack of literature on the long-term outcome. In particular, there is little evidence regarding the outcome of revisions of primary resurfacing. The purpose of this analysis was to examine the survivorship of primary resurfacing hip arthroplasties that have been revised. PATIENTS AND METHODS: Over 12,000 primary resurfacing hip arthroplasties were recorded by the Australian Orthopaedic Association National Joint Replacement Registry between September 1, 1999 and December 31, 2008. During this time, 397 revisions for reasons other than infection were reported for these primary resurfacings and classified as acetabular, femoral, or both acetabular and femoral revisions. The survivorship of the different types of revisions was estimated using the Kaplan-Meier method and compared using proportional hazard models. Additionally, the outcome of a femoral-only revision was compared to that of primary conventional total hip arthroplasty. RESULTS: Acetabular-only revision had a high risk of re-revision compared to femoral-only and both acetabular and femoral revision (5-year cumulative per cent revision of 20%, 7%, and 5% respectively). Femoral-only revision had a risk of re-revision similar to that of revision of both the acetabular and femoral components. Femoral-only revision had over twice the risk of revision of primary conventional total hip arthroplasty. INTERPRETATION: Revision of a primary resurfacing arthroplasty is associated with a major risk of re-revision. The best outcome is achieved when either the femoral-only or both the acetabular and femoral components are revised. Technically straightforward femoral-only revisions generally have a worse outcome than a primary conventional total hip arthroplasty
LSST Science Book, Version 2.0
A survey that can cover the sky in optical bands over wide fields to faint
magnitudes with a fast cadence will enable many of the exciting science
opportunities of the next decade. The Large Synoptic Survey Telescope (LSST)
will have an effective aperture of 6.7 meters and an imaging camera with field
of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over
20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with
fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a
total point-source depth of r~27.5. The LSST Science Book describes the basic
parameters of the LSST hardware, software, and observing plans. The book
discusses educational and outreach opportunities, then goes on to describe a
broad range of science that LSST will revolutionize: mapping the inner and
outer Solar System, stellar populations in the Milky Way and nearby galaxies,
the structure of the Milky Way disk and halo and other objects in the Local
Volume, transient and variable objects both at low and high redshift, and the
properties of normal and active galaxies at low and high redshift. It then
turns to far-field cosmological topics, exploring properties of supernovae to
z~1, strong and weak lensing, the large-scale distribution of galaxies and
baryon oscillations, and how these different probes may be combined to
constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at
http://www.lsst.org/lsst/sciboo
The Chandra Deep Wide-field Survey: A New Chandra Legacy Survey in the Boötes Field. I. X-Ray Point Source Catalog, Number Counts, and Multiwavelength Counterparts
We present a new, ambitious survey performed with the Chandra X-ray Observatory of the 9.3 deg2 Boötes field of the NOAO Deep Wide-Field Survey. The wide field probes a statistically representative volume of the universe at high redshift. The Chandra Deep Wide-field Survey exploits the excellent sensitivity and angular resolution of Chandra over a wide area, combining 281 observations spanning 15 yr, for a total exposure time of 3.4 Ms, and detects 6891 X-ray point sources down to limiting fluxes of 4.7 × 10−16, 1.5 × 10−16, and 9 ×10−16 erg cm−2 s−1 in the 0.5–7, 0.5–2, and 2–7 keV bands, respectively. The robustness and reliability of the detection strategy are validated through extensive, state-of-the-art simulations of the whole field. Accurate number counts, in good agreement with previous X-ray surveys, are derived thanks to the uniquely large number of point sources detected, which resolve 65.0% ± 12.8% of the cosmic X-ray background between 0.5 and 2 keV and 81.0% ± 11.5% between 2 and 7 keV. Exploiting the wealth of multiwavelength data available on the field, we assign redshifts to ~94% of the X-ray sources, estimate their obscuration, and derive absorption-corrected luminosities. We provide an electronic catalog containing all of the relevant quantities needed for future investigations
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