2,129 research outputs found
Synthesis of hetero-bifunctional, end-capped oligo-EDOT derivatives
Conjugated oligomers of 3,4-ethylenedioxythiophene (EDOT) are attractive materials for tissue engineering applications, and as model systems for studying the properties of the widely used polymer PEDOT. We report here the facile synthesis of a series of keto-acid end-capped oligo-EDOT derivatives (n = 2-7) through a combination of a glyoxylation end capping strategy and iterative direct arylation chain extension. Importantly, these structures not only represent the longest oligo-EDOTs reported, but are also bench stable in contrast to previous reports on such oligomers. The constructs reported here can undergo subsequent derivatization for integration into higher order architectures, such as those required for tissue engineering applications. The synthesis of hetero-bifunctional constructs, as well as those containing mixed monomer units is also reported, allowing further complexity to be installed in a controlled manner. Finally, we describe the optical and electrochemical properties of these oligomers and demonstrate the importance of the keto-acid in determining their characteristics
Electron Detectors for Electron-Beam Testing of Ultra Large Scale Integrated Circuits
The increasing density of components in integrated circuits imposes severe constraints on conventional electron beam testers. The use of electron detectors consisting of combined electrostatic and magnetic fields has demonstrated improved performance over conventional electrostatic detectors. Such detectors also ease many of the practical difficulties associated with electron beam testing of Ultra Large Scale Integration (ULSI) circuits. A detector using a single pole magnetic lens will be described and compared to detectors which use only electrostatic fields. The single pole lens detector has demonstrated superior performance to the electrostatic detector in terms of local field error and imaging resolution, allowing accurate measurements to be made on sub-micron structures
Tax evasion and exchange equity: a reference-dependent approach
The standard portfolio model of tax evasion with a public good produces the perverse conclusion that when taxpayers perceive the public good to be under-/overprovided, an increase in the tax rate increases/decreases evasion. The author treats taxpayers as thinking in terms of gains and losses relative to an endogenous reference level, which reflects perceived exchange equity between the value of taxes paid and the value of public goods supplied. With these alternative behavioral assumptions, the author overturns the aforementioned result in a direction consistent with the empirical evidence. The author also finds a role for relative income in determining individual responses to a change in the marginal rate of tax
Future possibilities in the prevention of breast cancer: Luteinizing hormone-releasing hormone agonists
The cyclic production of estrogen and progesterone by the premenopausal ovary accounts for the steep rise in breast cancer risk in premenopausal women. These hormones are breast cell mitogens. By reducing exposure to these ovarian hormones, agonists of luteinizing hormone-releasing hormone (LHRH) given to suppress ovarian function may prove useful in cancer prevention. To prevent deleterious effects of hypoestrogenemia, the addition of low-dose hormone replacement to the LHRH agonist appears necessary. Pilot data with such an approach indicates it is feasible and reduces mammographic densities
Higher analogues of the discrete-time Toda equation and the quotient-difference algorithm
The discrete-time Toda equation arises as a universal equation for the
relevant Hankel determinants associated with one-variable orthogonal
polynomials through the mechanism of adjacency, which amounts to the inclusion
of shifted weight functions in the orthogonality condition. In this paper we
extend this mechanism to a new class of two-variable orthogonal polynomials
where the variables are related via an elliptic curve. This leads to a `Higher
order Analogue of the Discrete-time Toda' (HADT) equation for the associated
Hankel determinants, together with its Lax pair, which is derived from the
relevant recurrence relations for the orthogonal polynomials. In a similar way
as the quotient-difference (QD) algorithm is related to the discrete-time Toda
equation, a novel quotient-quotient-difference (QQD) scheme is presented for
the HADT equation. We show that for both the HADT equation and the QQD scheme,
there exists well-posed -periodic initial value problems, for almost all
\s\in\Z^2. From the Lax-pairs we furthermore derive invariants for
corresponding reductions to dynamical mappings for some explicit examples.Comment: 38 page
Women and Illegal Activities: Gender Differences and Women's Willingness to Comply Over Time
In recent years the topics of illegal activities such as corruption or tax evasion have attracted a great deal of attention. However, there is still a lack of substantial empirical evidence about the determinants of compliance. The aim of this paper is to investigate empirically whether women are more willing to be compliant than men and whether we observe (among women and in general) differences in attitudes among similar age groups in different time periods (cohort effect) or changing attitudes of the same cohorts over time (age effect) using data from eight Western European countries from the World Values Survey and the European Values Survey that span the period from 1981 to 1999. The results reveal higher willingness to comply among women and an age rather than a cohort effect. Working Paper 06-5
Evaluating case studies of community-oriented integrated care.
This paper summarises a ten-year conversation within London Journal of Primary Care about the nature of community-oriented integrated care (COIC) and how to develop and evaluate it. COIC means integration of efforts for combined disease-treatment and health-enhancement at local, community level. COIC is similar to the World Health Organisation concept of a Community-Based Coordinating Hub - both require a local geographic area where different organisations align their activities for whole system integration and develop local communities for health. COIC is a necessary part of an integrated system for health and care because it enables multiple insights into 'wicked problems', and multiple services to integrate their activities for people with complex conditions, at the same time helping everyone to collaborate for the health of the local population. The conversation concludes seven aspects of COIC that warrant further attention
Impulsive phase flare energy transport by large-scale Alfven waves and the electron acceleration problem
The impulsive phase of a solar flare marks the epoch of rapid conversion of
energy stored in the pre-flare coronal magnetic field. Hard X-ray observations
imply that a substantial fraction of flare energy released during the impulsive
phase is converted to the kinetic energy of mildly relativistic electrons
(10-100 keV). The liberation of the magnetic free energy can occur as the
coronal magnetic field reconfigures and relaxes following reconnection. We
investigate a scenario in which products of the reconfiguration - large-scale
Alfven wave pulses - transport the energy and magnetic-field changes rapidly
through the corona to the lower atmosphere. This offers two possibilities for
electron acceleration. Firstly, in a coronal plasma with beta < m_e/m_p, the
waves propagate as inertial Alfven waves. In the presence of strong spatial
gradients, these generate field-aligned electric fields that can accelerate
electrons to energies on the order of 10 keV and above, including by repeated
interactions between electrons and wavefronts. Secondly, when they reflect and
mode-convert in the chromosphere, a cascade to high wavenumbers may develop.
This will also accelerate electrons by turbulence, in a medium with a locally
high electron number density. This concept, which bridges MHD-based and
particle-based views of a flare, provides an interpretation of the
recently-observed rapid variations of the line-of-sight component of the
photospheric magnetic field across the flare impulsive phase, and offers
solutions to some perplexing flare problems, such as the flare "number problem"
of finding and resupplying sufficient electrons to explain the impulsive-phase
hard X-ray emission.Comment: 31 pages, 6 figure
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Extending critical performativity
In this article we extend the debate about critical performativity. We begin by outlining the basic tenets of critical performativity and how this has been applied in the study of management and organization. We then address recent critiques of critical performance. We note these arguments suffer from an undue focus on intra-academic debates; engage in author-itarian theoretical policing; feign relevance through symbolic radicalism; and repackage common sense. We take these critiques as an opportunity to offer an extended model of critical performativity that involves focusing on issues of public importance; engaging with non-academic groups using dialectical reasoning; scaling up insights through movement building; and propagating deliberation
How primary care can contribute to good mental health in adults.
The need for support for good mental health is enormous. General support for good mental health is needed for 100% of the population, and at all stages of life, from early childhood to end of life. Focused support is needed for the 17.6% of adults who have a mental disorder at any time, including those who also have a mental health problem amongst the 30% who report having a long-term condition of some kind. All sectors of society and all parts of the NHS need to play their part. Primary care cannot do this on its own. This paper describes how primary care practitioners can help stimulate such a grand alliance for health, by operating at four different levels - as individual practitioners, as organisations, as geographic clusters of organisations and as policy-makers
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