144 research outputs found
RATAN-600 7.6-cm Deep Sky Strip Surveys at the Declination of the SS433 Source During the 1980-1999 Period. Data Reduction and the Catalog of Radio Sources in the Right-Ascension Interval 7h < R.A. < 17h
We use two independent methods to reduce the data of the surveys made with
RATAN-600 radio telescope at 7.6 cm in 1988-1999 at the declination of the
SS433 source. We also reprocess the data of the "Cold" survey (1980-1981). The
resulting RCR (RATAN COLD REFINED) catalog contains the right ascensions and
fluxes of objects identified with those of the NVSS catalog in the
right-ascension interval 7h < R.A. < 17h. We obtain the spectra of the radio
sources and determine their spectral indices at 3.94 and 0.5 GHz. The spectra
are based on the data from all known catalogs available from the CATS, Vizier,
and NED databases, and the flux estimates inferred from the maps of the VLSS
and GB6 surveys. For 245 of the 550 objects of the RCR catalog the fluxes are
known at two frequencies only: 3.94 GHz (RCR) and 1.4 GHz (NVSS). These are
mostly sources with fluxes smaller than 30 mJy. About 65% of these sources have
flat or inverse spectra (alpha > -0.5). We analyze the reliability of the
results obtained for the entire list of objects and construct the histograms of
the spectral indices and fluxes of the sources. Our main conclusion is that all
10-15 mJy objects found in the considered right-ascension interval were already
included in the decimeter-wave catalogs.Comment: 26 pages, 18 figure
Radio Spectra of Giant Radio Galaxies from RATAN-600 Data
Measurements of the flux densities of the extended components of seven giant
radio galaxies obtained using the RATAN-600 radio telescope at wavelengths of
6.25 and 13 cm ar e presented. The spectra of components of these radio
galaxies are constructed using these new RA TAN-600 data together with data
from the WENSS, NVSS, and GB6 surveys. The spectral indices in the stu died
frequency range are calculated, and the need for detailed estimates of the
integrated contributi on of such objects to the background emission is
demonstrated.Comment: 7 pages, 2 figures, 5 table
RC J0311+0507: A Candidate for Superpowerful Radio Galaxies in the Early Universe at Redshift z=4.514
A strong emission line at 6703A has been detected in the optical spectrum for
the host galaxy (R=23.1) of the radio source RC J0311+0507 (4C+04.11). This
radio galaxy, with a spectral index of 1.31 in the frequency range 365-4850
MHz, is one of the ultrasteep spectrum objects from the deep survey of a sky
strip conducted with RATAN-600 in 1980-1981. We present arguments in favor of
the identification of this line with Ly\alpha at redshift z=4.514. In this
case, the object belongs to the group of extremely distant radio galaxies of
ultrahigh radio luminosity (P_{1400}=1.3 x 10^{29}W Hz^{-1}). Such power can be
provided only by a fairly massive black hole (~10^9M_\sun}) that formed in a
time less than the age of the Universe at the observed z(1.3 Gyr) or had a
primordial origin.Comment: 8 pages, 3 figure
NCBI GEO: archive for high-throughput functional genomic data
The Gene Expression Omnibus (GEO) at the National Center for Biotechnology Information (NCBI) is the largest public repository for high-throughput gene expression data. Additionally, GEO hosts other categories of high-throughput functional genomic data, including those that examine genome copy number variations, chromatin structure, methylation status and transcription factor binding. These data are generated by the research community using high-throughput technologies like microarrays and, more recently, next-generation sequencing. The database has a flexible infrastructure that can capture fully annotated raw and processed data, enabling compliance with major community-derived scientific reporting standards such as āMinimum Information About a Microarray Experimentā (MIAME). In addition to serving as a centralized data storage hub, GEO offers many tools and features that allow users to effectively explore, analyze and download expression data from both gene-centric and experiment-centric perspectives. This article summarizes the GEO repository structure, content and operating procedures, as well as recently introduced data mining features. GEO is freely accessible at http://www.ncbi.nlm.nih.gov/geo/
A mouse model for Sorsby fundus dystrophy
purpose. Sorsby fundus dystrophy (SFD) is a rare, late-onset macular dystrophy caused by mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) gene. The known mutations introduce potentially unpaired cysteine residues in the C terminus of the protein and result in the formation of higher-molecular-weight protein complexes of as yet unknown composition and functional consequences in the pathologic course of SFD. To facilitate in vivo investigation of mutant TIMP3, the authors generated a knock-in mouse carrying a disease-related Ser156Cys mutation in the orthologous murine Timp3 gene.
methods. Site-directed mutagenesis and homologous recombination in embryonic stem (ES) cells was used to generate mutant ES cells carrying the Timp3 S156C allele. Chimeric animals were obtained, of which two displayed germline transmission of the mutated allele. Molecular genetic, biochemical, electron microscopic, and electrodiagnostic techniques were used for characterization.
results. At 8 months of age, knock-in mice showed abnormalities in the inner aspect of Bruchās membrane and in the organization of the adjacent basal microvilli of the retinal pigment epithelium (RPE). Changes resembling those in the mutant animals were also present to some extent in normal littermates, but only at an advanced age of 30 months. Long-term electrodiagnostic recordings indicated normal retinal function throughout life. The biochemical characteristics of the mutant protein appear similar in humans and knock-in mice, suggesting common molecular pathways in the two species. The localization of the mutant protein in the eye is normal, although there is evidence of increased Timp3 levels in Bruchās membrane of mutant animals.
conclusions. The knock-in mice display early features of age-related changes in Bruchās membrane and the RPE that may represent the primary clinical manifestations of SFD. In addition, our immunolabeling studies and biochemical data support a model proposing that site-specific excess rather than absence or deficiency of functional Timp3 may be the primary consequence of the known Timp3 mutations
On the Spectral Index of Distant Radio Galaxies
The problems of using the spectral index of radio galaxies in various tests,
in particular, in selecting distant radio sources are considered. The history
of the question of choosing a criterion of searching for distant radio galaxies
based on the spectral index is presented. For a new catalog of 2442 radio
galaxies constructed from NED, SDSS, and CATS data, an analytical form of the
sp ectral index.redshift relation has been determined for the first time. The
spectral index.angular size and spectral index.flux density diagrams have also
been constructed. Peculiarities of the distribution of sources on these
diagrams are discussed.Comment: 7 pages,5 figure
NCBI GEO: archive for functional genomics data setsā10 years on
A decade ago, the Gene Expression Omnibus (GEO) database was established at the National Center for Biotechnology Information (NCBI). The original objective of GEO was to serve as a public repository for high-throughput gene expression data generated mostly by microarray technology. However, the research community quickly applied microarrays to non-gene-expression studies, including examination of genome copy number variation and genome-wide profiling of DNA-binding proteins. Because the GEO database was designed with a flexible structure, it was possible to quickly adapt the repository to store these data types. More recently, as the microarray community switches to next-generation sequencing technologies, GEO has again adapted to host these data sets. Today, GEO stores over 20ā000 microarray- and sequence-based functional genomics studies, and continues to handle the majority of direct high-throughput data submissions from the research community. Multiple mechanisms are provided to help users effectively search, browse, download and visualize the data at the level of individual genes or entire studies. This paper describes recent database enhancements, including new search and data representation tools, as well as a brief review of how the community uses GEO data. GEO is freely accessible at http://www.ncbi.nlm.nih.gov/geo/
Catalog of Radio Galaxies with z>0.3. I:Construction of the Sample
The procedure of the construction of a sample of distant () radio
galaxies using NED, SDSS, and CATS databases for further application in
statistical tests is described. The sample is assumed to be cleaned from
objects with quasar properties. Primary statistical analysis of the list is
performed and the regression dependence of the spectral index on redshift is
found.Comment: 9 pages, 6 figures, 2 table
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