13,707 research outputs found
Looking for Design in Materials Design
Despite great advances in computation, materials design is still science
fiction. The construction of structure-property relations on the quantum scale
will turn computational empiricism into true design.Comment: 3 pages, 1 figur
Damage identification based on response-only measurements using cepstrum analysis and artificial neural networks
This article presents a response-only structural health monitoring technique that utilises cepstrum analysis and artificial neural networks for the identification of damage in civil engineering structures. The method begins by applying cepstrum-based operational modal analysis, which separates source and transmission path effects to determine the structure's frequency response functions from response measurements only. Principal component analysis is applied to the obtained frequency response functions to reduce the data size, and structural damage is then detected using a two-stage ensemble of artificial neural networks. The proposed method is verified both experimentally and numerically using a laboratory two-storey framed structure and a finite element representation, both subjected to a single excitation. The laboratory structure is tested on a large-scale shake table generating ambient loading of Gaussian distribution. In the numerical investigation, the same input is applied to the finite model, but the obtained responses are polluted with different levels of white Gaussian noise to better replicate real-life conditions. The damage is simulated in the experimental and numerical investigations by changing the condition of individual joint elements from fixed to pinned. In total, four single joint changes are investigated. The results of the investigation show that the proposed method is effective in identifying joint damage in a multi-storey structure based on response-only measurements in the presence of a single input. Because the technique does not require a precise knowledge of the excitation, it has the potential for use in online structural health monitoring. Recommendations are given as to how the method could be applied to the more general multiple-input case. Β© The Author(s) 2014
The implications of COP21 for our future climate
Rising CO2 in the atmosphere is the main cause of anthropogenic climate change, and the data shows a clear increase in global temperature of about 1 Β°C since pre-industrial levels. Changes in climate extremes are also occurring, with observed increases in the frequency of heat waves, in intense precipitation (rainfall and snowfall) in many places, and in sea level and storm surges. A changing climate with rising extremes has associated risks for food production and other health-related impacts. In order to limit climate change well below 2 Β°C, our carbon emissions must rapidly follow a decreasing trajectory to near zero
Measurement of Thermal Stress in Railroad Rails Using Ultrasonic SH Waves
The use of welded joints in railroad tracks has led to problems of rail buckling brought about by the development of large compressive stresses during hot days. On cold days, tensile stresses can actually fracture the rail. In order to prevent this source of derailments, it is desirable to develop an easily used instrument to measure the level of stress in an arbitrary section of track in the field. Ultrasonic birefringence, acoustic emission and certain magnetic phenomena have all been used to attack this problem but they all suffer from the necessity for calibrating the sensor under stress-free conditions in order to correct for metallurgical structure variations. A new ultrasonic technique based on using surface skimming shear horizontal ultrasonic waves generated and detected by EMATs was investigated here because it rigorously eliminates the effects of metallurgical texture as well as unreliable coupling of the transducer to the part. Tests on sections of rail mounted in a 200,000 pound testing machine at the University of New Mexico demonstrated that the theory for the basic phenomenon is correct and that the stress level can be measured in spite of the presence of considerable texture in the rail microstructure
How to Establish and Follow up a Large Prospective Cohort Study in the 21st Century - Lessons from UK COSMOS.
Large-scale prospective cohort studies are invaluable in epidemiology, but they are increasingly difficult and costly to establish and follow-up. More efficient methods for recruitment, data collection and follow-up are essential if such studies are to remain feasible with limited public and research funds. Here, we discuss how these challenges were addressed in the UK COSMOS cohort study where fixed budget and limited time frame necessitated new approaches to consent and recruitment between 2009-2012. Web-based e-consent and data collection should be considered in large scale observational studies, as they offer a streamlined experience which benefits both participants and researchers and save costs. Commercial providers of register and marketing data, smartphones, apps, email, social media, and the internet offer innovative possibilities for identifying, recruiting and following up cohorts. Using examples from UK COSMOS, this article sets out the dos and don'ts for today's cohort studies and provides a guide on how best to take advantage of new technologies and innovative methods to simplify logistics and minimise costs. Thus a more streamlined experience to the benefit of both research participants and researchers becomes achievable
Covering behavior of deep-water echinoids in Antarctica: possible response to predatory king crabs
This is the final version of the article. Available from Inter Research via the DOI in this record.Covering behavior refers to the propensity of echinoids (Echinoidea) to lift materials from the surrounding environment onto their aboral surfaces using their tube feet and spines. This behavior has been widely documented in regular echinoids from a variety of well-lit, shallow-marine habitats. Covering behavior in the deep sea, however, is rarely observed, and the functional significance of covering when it does occur remains speculative. During a photographic survey of the seafloor off Anvers Island and Marguerite Bay along the western Antarctic Peninsula, we imaged 11 benthic transects at depths ranging from 390 to 2100 m. We recorded the number of echinoid species, incidence of covering behavior, types of materials used for covering, potential predators of echinoids, and potential prey items for predators. The echinoid Sterechinus spp. was found at all depths, and the percentage of individuals exhibiting covering behavior increased with depth between 390 and 1500 m. There was a significant positive correlation between the incidence of covering behavior in Sterechinus spp. and the density of king crabs (Anomura: Lithodidae), crushing predators that may be expanding their bathymetric range up the Antarctic continental slope as a consequence of ongoing climatic warming. In contrast, covering behavior was not positively correlated with the densities of non-crab predators, the total densities of predators, or the availability of prey. Our results document rarely observed covering behavior in echinoids living in the deep sea and suggest that covering could be a behavioral response to predation pressure by king crabs.We thank the crew of the RV βNathaniel B. Palmerβ during the NBP13-10 cruise for logistical help, as well as J. S. Anderson, A. Brown, C. Easson, D. Ellis, S. Thatje, and S. C. Vos. Thanks also to Paul Dayton as well as 2 anonymous reviewers who offered constructive comments and suggestions. Funding was provided by grants from the US National Science Foundation to R.B.A. (ANT- 1141877) and J.B.M. (ANT-1141896). This paper is contribution no. 160 from the Institute for Research on Global Climate Change at the Florida Institute of Technology
A Foundry of Human Activities and Infrastructures
Direct representation knowledgebases can enhance and even provide an
alternative to document-centered digital libraries. Here we consider realist
semantic modeling of everyday activities and infrastructures in such
knowledgebases. Because we want to integrate a wide variety of topics, a
collection of ontologies (a foundry) and a range of other knowledge resources
are needed. We first consider modeling the routine procedures that support
human activities and technologies. Next, we examine the interactions of
technologies with aspects of social organization. Then, we consider approaches
and issues for developing and validating explanations of the relationships
among various entities
International Society of Sports Nutrition position stand: beta-alanine
Position statement: The International Society of Sports Nutrition (ISSN) provides an objective and critical review of the mechanisms and use of beta-alanine supplementation. Based on the current available literature, the conclusions of the ISSN are as follows: 1) Four weeks of beta-alanine supplementation (4β6 g daily) significantly augments muscle carnosine concentrations, thereby acting as an intracellular pH buffer; 2) Beta-alanine supplementation currently appears to be safe in healthy populations at recommended doses; 3) The only reported side effect is paraesthesia (tingling), but studies indicate this can be attenuated by using divided lower doses (1.6 g) or using a sustained-release formula; 4) Daily supplementation with 4 to 6 g of beta-alanine for at least 2 to 4 weeks has been shown to improve exercise performance, with more pronounced effects in open end-point tasks/time trials lasting 1 to 4 min in duration; 5) Beta-alanine attenuates neuromuscular fatigue, particularly in older subjects, and preliminary evidence indicates that beta-alanine may improve tactical performance; 6) Combining beta-alanine with other single or multi-ingredient supplements may be advantageous when supplementation of beta-alanine is high enough (4β6 g daily) and long enough (minimum 4 weeks); 7) More research is needed to determine the effects of beta-alanine on strength, endurance performance beyond 25 min in duration, and other health-related benefits associated with carnosine
Outstanding Issues in Solar Dynamo Theory
The magnetic activity of the Sun, as manifested in the sunspot cycle,
originates deep within its convection zone through a dynamo mechanism which
involves non-trivial interactions between the plasma and magnetic field in the
solar interior. Recent advances in magnetohydrodynamic dynamo theory have led
us closer towards a better understanding of the physics of the solar magnetic
cycle. In conjunction, helioseismic observations of large-scale flows in the
solar interior has now made it possible to constrain some of the parameters
used in models of the solar cycle. In the first part of this review, I briefly
describe this current state of understanding of the solar cycle. In the second
part, I highlight some of the outstanding issues in solar dynamo theory related
to the the nature of the dynamo -effect, magnetic buoyancy and the
origin of Maunder-like minima in activity. I also discuss how poor constraints
on key physical processes such as turbulent diffusion, meridional circulation
and turbulent flux pumping confuse the relative roles of these vis-a-vis
magnetic flux transport. I argue that unless some of these issues are
addressed, no model of the solar cycle can claim to be ``the standard model'',
nor can any predictions from such models be trusted; in other words, we are
still not there yet.Comment: To appear in "Magnetic Coupling between the Interior and the
Atmosphere of the Sun", eds. S.S. Hasan and R.J. Rutten, Astrophysics and
Space Science Proceedings, Springer-Verlag, Heidelberg, Berlin, 200
Estrogen receptor-Ξ± and progesterone receptor are expressed in label-retaining mammary epithelial cells that divide asymmetrically and retain their template DNA strands
INTRODUCTION: Stem cells of somatic tissues are hypothesized to protect themselves from mutation and cancer risk through a process of selective segregation of their template DNA strands during asymmetric division. Mouse mammary epithelium contains label-retaining epithelial cells that divide asymmetrically and retain their template DNA. METHOD: Immunohistochemistry was used in murine mammary glands that had been labeled with [(3)H]thymidine during allometric growth to investigate the co-expression of DNA label retention and estrogen receptor (ER)-Ξ± or progesterone receptor (PR). Using the same methods, we investigated the co-localization of [(3)H]thymidine and ER-Ξ± or PR in mammary tissue from mice that had received treatment with estrogen, progesterone, and prolactin subsequent to a long chase period to identify label-retaining cells. RESULTS: Label-retaining epithelial cells (LRECs) comprised approximately 2.0% of the entire mammary epithelium. ER-Ξ±-positive and PR-positive cells represented about 30β40% of the LREC subpopulation. Administration of estrogen, progesterone, and prolactin altered the percentage of LRECs expressing ER-Ξ±. CONCLUSION: The results presented here support the premise that there is a subpopulation of LRECs in the murine mammary gland that is positive for ER-Ξ± and/or PR. This suggests that certain mammary LRECs (potentially stem cells) remain stably positive for these receptors, raising the possibility that LRECs comprise a hierarchy of asymmetrically cycling mammary stem/progenitor cells that are distinguished by the presence or absence of nuclear steroid receptor expression
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