18F-FDOPA based radiation planning in modern care of glioblastoma multiforme

Célkitűzéseink között szerepelt az MR képalkotás fontosságának szemléltetése a primer rosszindulatú agydaganattal rendelkező betegek sebészi beavatkozás kiterjedésének megítélésére, továbbá szemléltetni a 18F-FDOPA PET/CT, PET/MR alkalmazását kivizsgálási, sugárterápiai, nyomonkövetési protokoll szerint. Kapott eredményeink alapján az MR képalkotás által validált, teljes reszekción átesett páciensek teljes túlélési ideje szignifikánsan hosszabbnak bizonyult a rezidualis daganattal rendelkező páciensekéhez viszonyítva. A 18F-FDOPA radiotracer aktivitás által definiált terület az esetek túlnyomó többségében többletinformációt mutat a kontrasztanyagos T1 súlyozott MR felvételeken definiált GTV-hez képest. Az utánkövetés során észlelt recidíva a teljes sugárdózist kapott terület határain belül jelentkezett. Az általunk alkalmazott képregisztrációs metódus lehetővé tette a 18F-FDOPA PET/CT és PET/MR felvételek közötti jelintenzitás standardizálását

A közúti forgalmi rend felülvizsgálata

Kutatásunkat közlekedésbiztonság területén végeztük. Napjainkban egyre fokozódó nemzetközi közlekedéspolitikai nyomás érzékelhető a közlekedésbiztonsági teljesítménymutatók javításának kikényszerítése területén. Ennek a cikknek a célja a forgalmi rend felülvizsgálatával kapcsolatos elsődleges eredmények bemutatása. Matematikai statisztikai eszközök széles csoportját alkalmaztuk, hogy megalkossuk Magyarország baleseti ponttérképét. Ezzel a térképpel jelentősen elősegíthető a döntéshozók munkássága a halálos közúti balesetek területén

Synthesis and structural features of a novel Ba(II)-Fe(III)-layered double hydroxide

Double hydroxides containing Ba(II) and Fe(III) have been prepared by the co-precipitation of a solution containing Ba(ClO4)2 and Fe(ClO4)3 in an extremely concentrated (up to 20 M) aqueous NaOH solution. The white to pale yellow compounds formed at [NaOH]T ≥ 10 M proved to have layered structure by powder XRD. To the best of our knowledge, this is the first report of layered double hydroxide (LDH) preparation from such highly concentrated base solutions. The interlayer distances of our Ba-Fe-LDHs proved to vary with the base concentration and aging. Ba-Fe-hydroxo-complex salts obtained by others under identical experimental conditions were 3– 4– claimed to consist of [Fe(OH)6] structural units at [NaOH]T = 10 M and [Fe(OH)7] ones at [NaOH]T = 20 M. EXAFS and XANES data indicated that the local environment of Fe(III) is 57 independent of [NaOH]T. From Fe Mössbauer spectroscopy, the local structure of Fe(III) in our Ba-Fe-LDHs is identical to that obtained for Na3Fe(OH)6.xNaOH, i.e., the Fe(III) is in octahedral environment, which is typical for the cationic components incorporated in the LDH structure

Temporal Relationship of Increased Palaeodischarges and Late Glacial Deglaciation Phases on the Catchment of River Maros/Mureş, Central Europe

River Maros/Mureş has one of the largest alluvial fans in the Carpathian Basin. On the surface of the fan several very wide, braided channels can be identified, resembling increased discharges during the Late Glacial. In our study we investigated the activity period of the largest channel of them, formed under a bankfull discharge three times higher than present day values. Previous investigations dated the formation of the palaeochannel to the very end of the Pleistocene by dating a point bar series upstream of the selected site. Our aim was to obtain further data on the activity period of the channel and to investigate temporal relationships between maximum palaeodischarges, deglaciation phases on the upland catchment and climatic amelioration during the Late Pleistocene. The age of sediment samples was determined by optically stimulated luminescence (OSL). The investigation of the luminescence properties of the quartz extracts also enabled the assessment of sediment delivery dynamics in comparison to other palaeochannels on the alluvial fan. OSL age results suggest that the activity of the channel is roughly coincident with, but slightly older than the previously determined ages, meaning that the main channel forming period started at 13.50±0.94 ka and must have ended by 8.64±0.82 ka. This period cannot directly be related to the major phases of glacier retreat on the upland catchments, and in terms of other high discharge channels only the activity of one overlaps with a major deglaciation phase at ~17-18 ka. Based on these, high palaeodischarges can be rather related to increased Late Glacial runoff, resulted by increasing precipitation and scarce vegetation cover on the catchment. Meanwhile, the quartz luminescence sensitivity of the investigated channel refers to fast sediment delivery from upland subcatchments. Therefore, the retreat of glaciers could affect alluvial processes on the lowland by increasing sediment availability, which contributed to the development of large braided palaeochannels

Temporal relationship of increased palaeodischarges and late glacial deglaciation phases on the catchment of river Maros/Mureş, Central Europe

River Maros/Mureş has one of the largest alluvial fans in the Carpathian Basin. On the surface of the fan several very wide, braided channels can be identified, resembling increased discharges during the Late Glacial. In our study we investigated the activity period of the largest channel of them, formed under a bankfull discharge three times higher than present day values. Previous investigations dated the formation of the palaeochannel to the very end of the Pleistocene by dating a point bar series upstream of the selected site. Our aim was to obtain further data on the activity period of the channel and to investigate temporal relationships between maximum palaeodischarges, deglaciation phases on the upland catchment and climatic amelioration during the Late Pleistocene. The age of sediment samples was determined by optically stimulated luminescence (OSL). The investigation of the luminescence properties of the quartz extracts also enabled the assessment of sediment delivery dynamics in comparison to other palaeochannels on the alluvial fan. OSL age results suggest that the activity of the channel is roughly coincident with, but slightly older than the previously determined ages, meaning that the main channel forming period started at 13.50±0.94 ka and must have ended by 8.64±0.82 ka. This period cannot directly be related to the major phases of glacier retreat on the upland catchments, and in terms of other high discharge channels only the activity of one overlaps with a major deglaciation phase at ~17-18 ka. Based on these, high palaeodischarges can be rather related to increased Late Glacial runoff, resulted by increasing precipitation and scarce vegetation cover on the catchment. Meanwhile, the quartz luminescence sensitivity of the investigated channel refers to fast sediment delivery from upland subcatchments. Therefore, the retreat of glaciers could affect alluvial processes on the lowland by increasing sediment availability, which contributed to the development of large braided palaeochannels

Visiting a Sakha (Yakut) Folk Healer

With a Musicological Note on the Blessing of the Sakha Healer by János Sipo