CONSIDERATION OF THE PSYCHOPHYSIOLOGICAL EFFECTS OF COLOR AND FONT GRAPHICS IN THE DESIGN OF THE EXHIBITION STAND

Рассмотрены вопросы психологического влияния цвета и шрифтовой графики, которые необходимо учитывать дизайнерам при разработке выставочных стендов. Грамотное применение шрифта и цвета позволит повысить коммерческую привлекательность проекта.The issues of psychological infl uence of color and font graphics, which designers need to take into account when developing exhibition stands, are considered. Proper use of font and color will increase the commercial attractiveness of the project

Combination of hypomorphic mutations of the Drosophila homologues of aryl hydrocarbon receptor and nucleosome assembly protein family genes disrupts morphogenesis, memory and detoxification

Aryl hydrocarbon receptor is essential for biological responses to endogenous and exogenous toxins in mammals. Its Drosophila homolog spineless plays an important role in fly morphogenesis. We have previously shown that during morphogenesis spineless genetically interacts with CG5017 gene, which encodes a nucleosome assembly factor and may affect cognitive function of the fly. We now demonstrate synergistic interactions of spineless and CG5017 in pathways controlling oxidative stress response and long-term memory formation in Drosophila melanogaster. Oxidative stress was induced by low doses of X-ray irradiation of flies carrying hypomorphic mutation of spineless, mutation of CG5017, and their combination. To determine the sensitivity of these mutants to pharmacological modifiers of the irradiation effect, we irradiated flies growing on standard medium supplemented by radiosensitizer furazidin and radioprotector serotonin. The effects of irradiation were investigated by analyzing leg and antenna morphological structures and by using real-time PCR to measure mRNA expression levels for spineless, Cyp6g1 and Gst-theta genes. We also examined long-term memory in these mutants using conditioned courtship suppression paradigm. Our results show that the interaction of spineless and CG5017 is important for regulation of morphogenesis, long-term memory formation, and detoxification during oxidative stress. Since spineless and CG5017 are evolutionary conserved, these results must be considered when evaluating the risk of combining similar mutations in other organisms, including humans

The program "client's voice" as a tool of business structure innovations

© by the author(s). The purpose of this article is aimed at improvement of interaction between a customer and a manufacturer on the basis of quality management methods development in the business structure. The article demonstrates the quality functions' structuring of the final product based on the study of explicit and implicit needs of the client at the products' design stage or its updating. The basis of the presented paper is the ideas of total quality Management, principles of products quality continuous improvement, production losses reduce and lean manufacturing. The article presents the concept of information support of the program "client's voice", which includes the necessary knowledge and information sources, method of information preservation and use, method of information formalizing from the client. This article is intended for business leaders, top Managers, researchers, all who are involved in the process of development and quality control in business organizations

Superior strength of carbon steel with an ultrafine-grained microstructure and its enhanced thermal stability

© 2015, Springer Science+Business Media New York. The paper presents the results of a study on the microstructure and mechanical properties of a medium-carbon steel (0.45 % C) processed by severe plastic deformation (SPD) via high-pressure torsion (HPT). Martensite quenching was first applied to the material, and then HPT processing was conducted at a temperature of 350 °C. As a result, a nanocomposite type microstructure is formed: an ultrafine-grained (UFG) ferrite matrix with fine cementite particles located predominantly at the boundaries of ferrite grains. The processed steel is characterized by a high-strength state, with an ultimate tensile strength over 2500 MPa. Special attention is given to analysis of the thermal stability of the microstructure and properties of the steel after HPT processing in comparison with quenching. It is shown that the thermal stability of the UFG structure produced by HPT is visibly higher than that of quenching-induced martensite. The origin of the enhanced strength and thermal stability of the UFG steel is discussed

Manifestation of Activity of Potentially Hazardous as regards Anthrax Areas across the Russian Federation under Current Conditions

Objective of the study is to investigate the activity of potentially hazardous as regards anthrax areas in the territory of the Russian Federation in 2001–2016. Materials and methods. The data was represented by the information contained in official reporting forms of the Department for Veterinary of the Ministry of Agriculture, statistical information from the Rospotrebnadzor and Rosselkhoznadzor on anthrax morbidity rates among animals and humans in our country, information on foci investigation and surveillance, cadastre of potentially hazardous as regards anthrax areas of the Russian Federation with amendments and additions included, as well as materials from publications and results of personal researches. Results and conclusions. The data on the contemporary manifestations of activity of 135 stationary potentially hazardous as regards anthrax areas of the Russian federation have been systematized and summarized; given has been the characteristics of old, relapsing, and new stationary hazardous as regards anthrax areas, registered in the Russian Federation since the beginning of the XXI century

The inter-chamber differences in the contractile function between left and right atrial cardiomyocytes in atrial fibrillation in rats

Introduction: The left and right atria (LA, RA) work under different mechanical and metabolic environments that may cause an intrinsic inter-chamber diversity in structure and functional properties between atrial cardiomyocytes (CM) in norm and provoke their different responsiveness to pathological conditions. In this study, we assessed a LA vs. RA difference in CM contractility in paroxysmal atrial fibrillation (AF) and underlying mechanisms. Methods: We investigated the contractile function of single isolated CM from LA and RA using a 7-day acetylcholine (ACh)-CaCl2 AF model in rats. We compared auxotonic force, sarcomere length dynamics, cytosolic calcium ([Ca2+]i) transients, intracellular ROS and NO production in LA and RA CM, and analyzed the phosphorylation levels of contractile proteins and actin-myosin interaction using an in vitro motility assay. Results: AF resulted in more prominent structural and functional changes in LA myocardium, reducing sarcomere shortening amplitude, and velocity of sarcomere relengthening in mechanically non-loaded LA CM, which was associated with the increased ROS production, decreased NO production, reduced myofibrillar content, and decreased phosphorylation of cardiac myosin binding protein C and troponin I. However, in mechanically loaded CM, AF depressed the auxotonic force amplitude and kinetics in RA CM, while force characteristics were preserved in LA CM. Discussion: Thus, inter-atrial differences are increased in paroxysmal AF and affected by the mechanical load that may contribute to the maintenance and progression of AF. 2023 Butova, Myachina, Simonova, Kochurova, Mukhlynina, Kopylova, Shchepkin and Khokhlova.Russian Science Foundation, RSF: 22-75-10134This research was supported by the Russian Science Foundation #22-75-10134. The work was performed using the equipment of the Shared Research Center of Scientific Equipment of Institute of Immunology and Physiology. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.This research was supported by the Russian Science Foundation #22-75-10134. The work was performed using the equipment of the Shared Research Center of Scientific Equipment of Institute of Immunology and Physiology. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript

Traditional Eastern European diet and mortality: prospective evidence from the HAPIEE study

PURPOSE: Cardiovascular disease (CVD) and cancer mortality rates in Eastern Europe are among the highest in the world. Although diet is an important risk factor, traditional eating habits in this region have not yet been explored. This analysis assessed the relationship between traditional dietary pattern and mortality from all-causes, CVD and cancer in Eastern European cohorts. METHODS: Data from the Health, Alcohol and Psychosocial factors in Eastern Europe prospective cohort were used, including participants from Russia, Poland and the Czech Republic. Based on food frequency questionnaire data, we constructed an Eastern European diet score (EEDS) from nine food groups which can be considered as traditional in this region. The relationship between categorical (low, moderate, high) and continuous (range 0-18) EEDS and mortality was estimated with Cox-regression. RESULTS: From 18,852 eligible participants, 2234 died during follow-up. In multivariable adjusted models, participants with high adherence to the traditional Eastern European diet had significantly higher risk of all-cause (HR 1.23; 95% CI 1.08-1.42) and CVD (1.34; 1.08-1.66) deaths compared to those with low adherence. The association with cancer mortality was only significant in Poland (high vs. low EEDS: 1.41; 1.00-1.98). From the specific EEDS components, high consumption of lard was significantly positively related to all three mortality outcomes, while preserved fruit and vegetable consumption showed consistent inverse associations. CONCLUSION: Our results suggest that traditional eating habits may contribute to the poor health status, particularly the high CVD mortality rates, of populations in Eastern Europe. Adequate public health nutritional interventions in this region are essential

Diffuse-Charge Dynamics in Electrochemical Systems

The response of a model micro-electrochemical system to a time-dependent applied voltage is analyzed. The article begins with a fresh historical review including electrochemistry, colloidal science, and microfluidics. The model problem consists of a symmetric binary electrolyte between parallel-plate, blocking electrodes which suddenly apply a voltage. Compact Stern layers on the electrodes are also taken into account. The Nernst-Planck-Poisson equations are first linearized and solved by Laplace transforms for small voltages, and numerical solutions are obtained for large voltages. The ``weakly nonlinear'' limit of thin double layers is then analyzed by matched asymptotic expansions in the small parameter $\epsilon = \lambda_D/L$, where $\lambda_D$ is the screening length and $L$ the electrode separation. At leading order, the system initially behaves like an RC circuit with a response time of $\lambda_D L / D$ (not $\lambda_D^2/D$), where $D$ is the ionic diffusivity, but nonlinearity violates this common picture and introduce multiple time scales. The charging process slows down, and neutral-salt adsorption by the diffuse part of the double layer couples to bulk diffusion at the time scale, $L^2/D$. In the ``strongly nonlinear'' regime (controlled by a dimensionless parameter resembling the Dukhin number), this effect produces bulk concentration gradients, and, at very large voltages, transient space charge. The article concludes with an overview of more general situations involving surface conduction, multi-component electrolytes, and Faradaic processes.Comment: 10 figs, 26 pages (double-column), 141 reference

ANTHRAX IN THE TERRITORY OF YAMAL: ASSESSMENT OF EPIZOOTIOLOGICAL AND EPIDEMIOLOGICAL RISKS

Objective of the study was to analyze epizootiological and epidemiological risks contributing to the development of anthrax outbreak in the Yamal peninsular in July-August, 2016. Materials and methods. Risks were evaluated using complex approach allowing for determination of the impact of epidemiologically significant social, natural, and biological risks, based on literature sources, archival data, and statistical reports. Special focus was on the natural-climatic factors, providing for persistence of the agent in the environment, such as NDVI index, atmospheric temperature and humidity, as well as soil temperature and moisture at different depths, in accordance with satellite monitoring. Results and conclusions. Justified was the hypothesis on sustained adversity of soil foci in Yamal, remaining hazard of aggravation of epizootiological and epidemiological situation on anthrax against the background of changing environmental and social risk factors, as well as agent ability to survive in the soils within an indeterminate amount of time

Biophysical and electrochemical studies of protein-nucleic acid interactions

This review is devoted to biophysical and electrochemical methods used for studying protein-nucleic acid (NA) interactions. The importance of NA structure and protein-NA recognition for essential cellular processes, such as replication or transcription, is discussed to provide background for description of a range of biophysical chemistry methods that are applied to study a wide scope of protein-DNA and protein-RNA complexes. These techniques employ different detection principles with specific advantages and limitations and are often combined as mutually complementary approaches to provide a complete description of the interactions. Electrochemical methods have proven to be of great utility in such studies because they provide sensitive measurements and can be combined with other approaches that facilitate the protein-NA interactions. Recent applications of electrochemical methods in studies of protein-NA interactions are discussed in detail