Fundraising as organisational knowing in practice: Evidence from the arts and higher education in the UK

This paper argues for the centrality of organisational practices in occupational learning with a case study of fundraising in the non‐profit UK's arts and higher education sectors. Despite the need to increase charitable giving to non‐profit organisations, little is known about the work, fundraisers must do in order to carry out their jobs. We argue that fundraisers develop strategic understandings and competences within organisational environments, which they put into practice in their relationships with stakeholders within and outside the organisations where they work. Our findings suggest that one of the main ways in which fundraisers learn is by negotiating and surmounting obstacles both internally, within their organisational environments and externally, around the perception of fundraising as a profession. We thus argue for the importance of establishing a “fundraising culture” within organisational environments; a shared organisational competence where fundraising is practiced as a legitimate and strategic type of practice

Vision-based deep execution monitoring

Execution monitor of high-level robot actions can be effectively improved by visual monitoring the state of the world in terms of preconditions and postconditions that hold before and after the execution of an action. Furthermore a policy for searching where to look at, either for verifying the relations that specify the pre and postconditions or to refocus in case of a failure, can tremendously improve the robot execution in an uncharted environment. It is now possible to strongly rely on visual perception in order to make the assumption that the environment is observable, by the amazing results of deep learning. In this work we present visual execution monitoring for a robot executing tasks in an uncharted Lab environment. The execution monitor interacts with the environment via a visual stream that uses two DCNN for recognizing the objects the robot has to deal with and manipulate, and a non-parametric Bayes estimation to discover the relations out of the DCNN features. To recover from lack of focus and failures due to missed objects we resort to visual search policies via deep reinforcement learning

Observability of Dual Active Galactic Nuclei in Merging Galaxies

Supermassive black holes (SMBHs) have been detected in the centers of most nearby massive galaxies. Galaxies today are the products of billions of years of galaxy mergers, but also billions of years of SMBH activity as active galactic nuclei (AGNs) that is connected to galaxy mergers. In this context, detection of AGN pairs should be relatively common. Observationally, however, dual AGN are scant, being just a few percent of all AGN. In this Letter we investigate the triggering of AGN activity in merging galaxies via a suite of high resolution hydrodynamical simulations. We follow the dynamics and accretion onto the SMBHs as they move from separations of tens of kiloparsecs to tens of parsecs. Our resolution, cooling and star formation implementation produce an inhomogeneous, multi-phase interstellar medium, allowing us to accurately trace star formation and accretion onto the SMBHs. We study the impact of gas content, morphology, and mass ratio, allowing us to study AGN activity and dynamics across a wide range of relevant conditions. We test when the two AGN are simultaneously detectable, for how long and at which separations. We find that strong dual AGN activity occurs during the late phases of the mergers, at small separations (<1-10 kpc) below the resolution limit of most surveys. Much of the SMBH accretion is not simultaneous, limiting the dual AGN fraction detectable through imaging and spectroscopy to a few percent, in agreement with observational samples.Comment: Published in ApJL; additional material available at http://www.astro.lsa.umich.edu/~svanwas/dualAGN.htm

Calsequestrins in skeletal and cardiac muscle from adult Danio rerio

Calsequestrin (Casq) is a high capacity, low affinity Ca2+-binding protein, critical for Ca2+-buffering in cardiac and skeletal muscle sarcoplasmic reticulum. All vertebrates have multiple genes encoding for different Casq isoforms. Increasing interest has been focused on mammalian and human Casq genes since mutations of both cardiac (Casq2) and skeletal muscle (Casq1) isoforms cause different, and sometime severe, human pathologies. Danio rerio (zebrafish) is a powerful model for studying function and mutations of human proteins. In this work, expression, biochemical properties cellular and sub-cellular localization of D. rerio native Casq isoforms are investigated. By quantitative PCR, three mRNAs were detected in skeletal muscle and heart with different abundances. Three zebrafish Casqs: Casq1a, Casq1b and Casq2 were identified by mass spectrometry (Data are available via ProteomeXchange with identifier PXD002455). Skeletal and cardiac zebrafish calsequestrins share properties with mammalian Casq1 and Casq2. Skeletal Casqs were found primarily, but not exclusively, at the sarcomere Z-line level where terminal cisternae of sarcoplasmic reticulum are located

Biomonitoring of firefighting forces: a review on biomarkers of exposure to health-relevant pollutants released from fires

Occupational exposure as a firefighter has recently been classified as a carcinogen to humans by International Agency for Research on Cancer (IARC). Biomonitoring has been increasingly used to characterize exposure of firefighting forces to contaminants. However, available data are dispersed and information on the most relevant and promising biomarkers in this context of firefighting is missing. This review presents a comprehensive summary and critical appraisal of existing biomar-kers of exposure including volatile organic compounds such as polycyclic aromatic hydrocarbons, several other persistent other organic pollutants as well as heavy metals and metalloids detected in biological fluids of firefighters attending different fire scenarios. Urine was the most characterized matrix, followed by blood. Firefighters exhaled breath and saliva were poorly evaluated. Overall, biological levels of compounds were predominantly increased in firefighters after participation in firefighting activities. Biomonitoring studies combining different biomarkers of exposure and of effect are currently limited but exploratory findings are of high interest. However, biomonitoring still has some unresolved major limitations since reference or recommended values are not yet established for most biomarkers. In addition, half-lives values for most of the biomarkers have thus far not been defined, which significantly hampers the design of studies. These limitations need to be tackled urgently to improve risk assessment and support implementation of better more effective preventive strategies.This work received support by UIDB/50006/2020, UIDP/ 50006/2020, LA/P/0008/2020, and through the project PCIF/ SSO/0090/2019 by the Fundação para a Ciência e a Tecnologia (FCT), Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through national funds. The authors would also like to thank to FCT and European Union through Fundo Social Europeu (FSE) which supported the scientific contract CEEC- Individual 2017 Program Contract CEECIND/03666/2017 and the PhD grant 2020.07394.BD, respectively.info:eu-repo/semantics/publishedVersio

Unveiling Urinary Mutagenicity by the Ames Test for Occupational Risk Assessment: A Systematic Review

Occupational exposure may involve a variety of toxic compounds. A mutagenicity analysis using the Ames test can provide valuable information regarding the toxicity of absorbed xenobiotics. Through a search of relevant databases, this systematic review gathers and critically discusses the published papers (excluding other types of publications) from 2001–2021 that have assessed urinary mutagenicity (Ames test with Salmonella typhimurium) in an occupational exposure context. Due to the heterogeneity of the study methods, a meta-analysis could not be conducted. The characterized occupations were firefighters, traffic policemen, bus drivers, mail carriers, coke oven and charcoal workers, chemical laboratory staff, farmers, pharmacy workers, and professionals from several other industrial sectors. The genetically modified bacterial strains (histidine dependent) TA98, TA100, YG1041, YG1021, YG1024 and YG1042 have been used for the health risk assessment of individual (e.g., polycyclic aromatic hydrocarbons) and mixtures of compounds (e.g., diesel engine exhaust, fire smoke, industrial fumes/dyes) in different contexts. Although comparison of the data between studies is challenging, urinary mutagenicity can be very informative of possible associations between work-related exposure and the respective mutagenic potential. Careful interpretation of results and their direct use for occupational health risk assessment are crucial and yet complex; the use of several strains is highly recommended since individual and/or synergistic effects of complex exposure to xenobiotics can be overlooked. Future studies should improve the methods used to reach a standardized protocol for specific occupational environments to strengthen the applicability of the urinary mutagenicity assay and reduce inter- and intra-individual variability and exposure source confoundersThis work received financial support from the projects PCIF/SSO/0017/2018 and PCIF/SSO/0090/2019 of the Fundação para a Ciência e a Tecnologia (FCT), Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through national funds. This work received support from UIDB/50006/2020, UIDP/50006/2020 and LA/P/0008/2020. M. Oliveira and B. Barros were supported by the scientific contract CEEC Individual 2017 Program Contract CEECIND/03666/2017 and the Ph.D. grant 2020.07394.BD, respectively. These were supported by the FCT and the European Union through the Fundo Social Europeu (FSE) and Ministério da Ciência, Tecnologia e Ensino Superior, respectively.info:eu-repo/semantics/publishedVersio

The Value of "Social" Reputation: The Protection of MNE Workers from the Consumer's Perspective

Abstract The virtually immediate information propagation has reduced the gap of knowledge once existing between MNEs and customers (i.e. Rana Plaza collapse, 2013). Consumers begin playing an important role in supporting workers. Their growing social awareness has clear economic consequences. MNEs have tried to react to the loss of social reputation, mainly adopting (and imposing to their suppliers) codes of conduct and ethics providing a minimum standard for decent work standards. This article aims to analyze the social reputation and social sustainability that have recently attracted stakeholders' interest, from different points of view (MNEs, consumers, government and non-government organizations, unions). Those "new" forms of social initiatives (code of conduct, social ranking, consumers campaign, boycotting) are informative and could help to spread ILO labour standards. Clearly, they can represent only an additional support for workers who are struggling in the typical conflict between Work and Capital. The tendency to use a single parameter for assessing the social sensitivity of the MNEs, valid both for the countries "in development" and for those "already developed" risks to lead to a "race to the bottom" trend

The Bright and Dark Side of DNA Methylation: A Matter of Balance

DNA methylation controls several cellular processes, from early development to old age, including biological responses to endogenous or exogenous stimuli contributing to disease transition. As a result, minimal DNA methylation changes during developmental stages drive severe phenotypes, as observed in germ-line imprinting disorders, while genome-wide alterations occurring in somatic cells are linked to cancer onset and progression. By summarizing the molecular events governing DNA methylation, we focus on the methods that have facilitated mapping and understanding of this epigenetic mark in healthy conditions and diseases. Overall, we review the bright (health-related) and dark (disease-related) side of DNA methylation changes, outlining how bulk and single-cell genomic analyses are moving toward the identification of new molecular targets and driving the development of more specific and less toxic demethylating agents