Southern Cross Soloists 2017 Concert Season

Ensemble in Residence at the Queensland Performing Arts Centre, the Southern Cross Soloists present three concerts with guest performers Damien Beaumont (presenter) and Alexandra Flood (soprano). Featuring music of all periods from the history of Western art music up to today, with new works by Australian composers Elena Kats-Chernin and John Rotar

Southern Cross Soloists Season 2016

Ensemble in Residence at the Queensland Performing Arts Centre, Southern Cross Soloists present three concerts: Forbidden Love (with Jack Liebeck, Violin)– 20th March 2016 at 3pm Visions of Earth (with William Barton, Didjeridu)– 19th June 2016 at 3pm Heavenly Voice (with Sara Macliver, Soprano)– 27th November 2016 at 3p

Bella España

The Resonate concert series for 2015 brings art and music together in a highly original program featuring some of Australia’s best-loved performers. An internationally successful ensemble based at the Queensland Performing Arts Centre in Brisbane, the Southern Cross Soloists have helped set the benchmark for Australian chamber music since 1995. The Soloists have earned a well-deserved reputation for artistic excellence and continue to surprise and delight audiences with their constantly evolving repertoire and ever-changing annual programs. Their informal, up-close-and-personal performance style creates an intimate, inviting and deeply engaging experience. Acclaimed guitarist Slava Grigoryan joins the Southern Cross Soloists to present Bella España, a fiery program of Latin-influenced works celebrating dance and romance. Grigoryan, already a favourite with Gallery audiences, is one of Australia’s most renowned classical guitarists and a former Young Australian of the Year for the arts. In this program, works by Granados, De Falla and De Milan are paired with the flaming sounds of Villa-Lobos and Piazzolla, showcasing the beauty and intimacy of chamber music and the brilliance of the Spanish guitar

Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors

The clinical significance of gene fusions detected by DNA-based next generation sequencing remains unclear as resistance mechanisms to EGFR tyrosine kinase inhibitors in EGFR mutant non-small cell lung cancer. By studying EGFR inhibitor-resistant patients treated with a combination of an EGFR inhibitor and a drug targeting the putative resistance-causing fusion oncogene, we identify patients who benefit and those who do not from this treatment approach. Through evaluation including RNA-seq of potential drug resistance-imparting fusion oncogenes in 504 patients with EGFR mutant lung cancer, we identify only a minority of them as functional, potentially capable of imparting EGFR inhibitor resistance. We further functionally validate fusion oncogenes in vitro using CRISPR-based editing of EGFR mutant cell lines and use these models to identify known and unknown drug resistance mechanisms to combination therapies. Collectively, our results partially reveal the complex nature of fusion oncogenes as potential drug resistance mechanisms and highlight approaches that can be undertaken to determine their functional significance.</p

Southern Cross Soloists 2015 Concert Series: 20th Anniversary Celebrations: Bella Espana, French Revelations, Great Legends

QPAC presents Southern Cross Soloists in "Great Legends", a concert featuring the music of Purcell, Mendelssohn, Schubert, Grieg and Beethoven, as well as two world premieres: Elena Kats-Chernin's 'Birthday Vignette', composed for the 20th anniversary of the Southern Cross Soloists, and Joseph Twist's 'Great Minds'. With guest performers Teddy Tahu Rhodes (bass baritone) and Jayson Gillam (piano), the program ranges from the rarified heights of Beethoven's 'Ghost' Trio and Schubert's famous 'Erlkönig' to the folk music of the Celtic people. French Revelations, 28 June 2015, with Piers Lane and Marshall McGuire: Rebel Le Chaos from Les Élémens Reynaldo Hahn Songs including: A Chloris Si mes vers avaient des ailes Poulenc Trio for oboe, bassoon and piano FP 43 Massenet Méditation from Thaïs Chausson Chanson perpétuelle Op. 37 Poulenc Flute Sonata FP164 Ravel Introduction and Allegro in G fl at M.46 Saint Saëns Allegro Scherzando and Presto from Piano Concerto No. 2 in G minor Op. 22 Bella Espana, with Slava Grigoryan, Alex Raineri, 1 March 2015: Vivaldi La Folia Trio Concerto in D minor Op. 1 No. 12 De Milan Two Romances Shchedrin In the Style of Albeniz Villa Lobos Guitar Concerto W502 Daniel Rojas Danzas amorosa Rodrigo Madrigals De Falla Nights in the Garden of Spai