Effects of electrical charging on the mechanical Q of a fused silica disk

We report on the effects of an electrical charge on mechanical loss of a fused silica disk. A degradation of Q was seen that correlated with charge on the surface of the sample. We examine a number of models for charge damping, including eddy current damping and loss due to polarization. We conclude that rubbing friction between the sample and a piece of dust attracted by the charged sample is the most likely explanation for the observed loss.Comment: submitted to Review of Scientific Instrument

Infrared Instrumentation and Astronomy

Contains reports on five research projects.Joint Services Electronics Program (Contract DAAB07-76-C-1400)National Aeronautics and Space Administration (Grant NGR 22-009-526)National Aeronautics and Space Administration (Grant NSG-7328)National Aeronautics and Space Administration (Contract NAS5-24096

Towards Gravitational Wave Signals from Realistic Core Collapse Supernova Models

We have computed the gravitational wave signal from supernova core collapse using the presently most realistic input physics available. We start from state-of-the-art progenitor models of rotating and non-rotating massive stars, and simulate the dynamics of their core collapse by integrating the equations of axisymmetric hydrodynamics together with the Boltzmann equation for the neutrino transport including an elaborate description of neutrino interactions, and a realistic equation of state. We compute the quadrupole wave amplitudes, the Fourier wave spectra, the amount of energy radiated in form of gravitational waves, and the S/N ratios for the LIGO and the tuned Advanced LIGO interferometers resulting both from non-radial mass motion and anisotropic neutrino emission. The simulations demonstrate that the dominant contribution to the gravitational wave signal is produced by neutrino-driven convection behind the supernova shock. For stellar cores rotating at the extreme of current stellar evolution predictions, the core-bounce signal is detectable with advanced LIGO up to a distance of 5kpc, whereas the signal from post-shock convection is observable up to a distance of about 100kpc. If the core is non-rotating its gravitational wave emission can be measured up to a distance of 15kpc, while the signal from the Ledoux convection in the deleptonizing, nascent neutron star can be detected up to a distance of 10kpc. Both kinds of signals are generically produced by convection in any core collapse supernova.Comment: 9 pages, 13 figures, Latex, submitted to ApJ, error in ps-file fixed; figures in full resolution are available upon reques

X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket

AbstractThe serine/threonine checkpoint kinase 2 (Chk2) is an attractive molecular target for the development of small molecule inhibitors to treat cancer. Here, we report the rational design of Chk2 inhibitors that target the gatekeeper-dependent hydrophobic pocket located behind the adenine-binding region of the ATP-binding site. These compounds exhibit IC50 values in the low nanomolar range and are highly selective for Chk2 over Chk1. X-ray crystallography was used to determine the structures of the inhibitors in complex with the catalytic kinase domain of Chk2 to verify their modes of binding

Seismic isolation of Advanced LIGO: Review of strategy, instrumentation and performance

The new generation of gravitational waves detectors require unprecedented levels of isolation from seismic noise. This article reviews the seismic isolation strategy and instrumentation developed for the Advanced LIGO observatories. It summarizes over a decade of research on active inertial isolation and shows the performance recently achieved at the Advanced LIGO observatories. The paper emphasizes the scientific and technical challenges of this endeavor and how they have been addressed. An overview of the isolation strategy is given. It combines multiple layers of passive and active inertial isolation to provide suitable rejection of seismic noise at all frequencies. A detailed presentation of the three active platforms that have been developed is given. They are the hydraulic pre-isolator, the single-stage internal isolator and the two-stage internal isolator. The architecture, instrumentation, control scheme and isolation results are presented for each of the three systems. Results show that the seismic isolation sub-system meets Advanced LIGO's stringent requirements and robustly supports the operation of the two detectors.Laser Interferometer Gravitational-Wave ObservatoryNational Science Foundation (U.S.

The discrete energy method in numerical relativity: Towards long-term stability

The energy method can be used to identify well-posed initial boundary value problems for quasi-linear, symmetric hyperbolic partial differential equations with maximally dissipative boundary conditions. A similar analysis of the discrete system can be used to construct stable finite difference equations for these problems at the linear level. In this paper we apply these techniques to some test problems commonly used in numerical relativity and observe that while we obtain convergent schemes, fast growing modes, or ``artificial instabilities,'' contaminate the solution. We find that these growing modes can partially arise from the lack of a Leibnitz rule for discrete derivatives and discuss ways to limit this spurious growth.Comment: 18 pages, 22 figure