Conveni de col·laboració entre l'Ajuntament de Barcelona i Fundación Ship2b per al projecte X SHIP2B IMPACT FORUM i Programa ACCELERACIÓ TECH4CLIMATE

Aprovat entre l'Ajuntament de Barcelona i la Fundación Ship2B el 28-12-2023

КЛИНИЧЕСКИЕ ПРОЯВЛЕНИЯ, ИНТЕНСИВНОСТЬ ПРОЦЕССОВ ПЕРЕКИСНОГО ОКИСЛЕНИЯ ЛИПИДОВ И ОСОБЕННОСТИ СИНТЕЗА ОКСИДА АЗОТА У БОЛЬНЫХ РОЖЕЙ

65 patients with a diagnosis of erysipelas. Examination of the patients included an analysis of lipid peroxidation products (common polyene, diene conjugates, and conjugate ketodieny trieny, Schiff bases), antioxidant defense system (enzymatic activity of superoxide dismutase) and nitric oxide metabolites (nitrates and nitrites). It was established that imbalance between excess activated lipid peroxidation and inadequate functioning of antioxidant defense system was remained during the entire period of the disease. The relationships between nitric oxide and lipid peroxidation were established. It was proved the advisability of developing and introducing new, improved schemes of pathogenetic therapy of erysipelas.Обследовано 65 больных рожей. В периферической крови определялось содержание продуктов перекисного окисления липидов (общие полиеновые, диеновые конъюгаты, кетодиены и сопряженные триены, основания Шиффа), состояние антиоксидантной защитной системы (ферментативная активность супероксиддисмутазы), а также метаболитов оксида азота (нитратов и нитритов). Установлено, что на протяжении всего периода болезни сохраняется выраженный дисбаланс между избыточно активированными процессами липопероксидации и недостаточно функционирующей антиоксидантной защитной системой. Установлена взаимосвязь между нитроксидергическими процессами и процессами липопероксидации. С учетом полученных данных обоснована целесообразность разработки и внедрения новых, более совершенных схем патогенетической терапии рожи

Saliva-based colorimetric test as an index of gingival inflammation in epidemiologic studies

– There is a pressing need for a reliable, low-cost method of assessing the gingival and periodontal status of large population groups. Existing indexes, despite their value in dental public health, are still too subject to examiner variability for use by uncalibrated examiners. This study describes an evaluation of a quick, inexpensive, extraoral colorimetric test for gingival inflammation, based on a reaction between saliva and the test material. It could probably be applied by non-professional personnel. In this study, the test was applied to a population of elementary schoolchildren, denial hygiene students and faculty, and adult inmates of two correctional institutions. These populations were chosen on the assumption that they would exhibit varying intensities of gingival inflammation. Values obtained from the colorimetric test carried out by one researcher were compared with Gingival Index (GI) scores observed by a different examiner. Results suggest that the colorimetric test may be a valid, reliable means of detecting major differences in the prevalence of gingival inflammation in most adult populations, although having little, if any, useful application among children at the mixed dentition stage.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73489/1/j.1600-0528.1978.tb01169.x.pd

The diagnostic suitability of a xerostomia questionnaire and the association between xerostomia, hyposalivation and medication use in a group of nursing home residents

The study objective was to explore the diagnostic suitability of the Xerostomia Inventory and the association between xerostomia, hyposalivation and medication use in a group of nursing home residents. A cross-sectional study was carried out in 50 physically impaired nursing home residents (20 men) with a mean age of 78.1 years (range, 53–98) in The Netherlands. The Xerostomia Inventory-Dutch version was completed for all residents and the data were subjected to exploratory factor analysis to determine the diagnostic suitability. Residents’ data on xerostomia, whole saliva secretion rates and hyposalivation-related medications used were collected and statistically analyzed. The diagnostic suitability of the Xerostomia Inventory-Dutch version appeared restricted. The prevalence of xerostomia was 52%, without gender and age difference. The prevalence of hyposalivation was 24% for resting, 60% for chewing-stimulated and 18% for acid-stimulated whole saliva. All whole saliva secretion rates were significantly lower in women than in men and in older than in younger residents. Forty-four percent of all medications used were hyposalivation-related and women used significantly more medications than men. Xerostomia was significantly negatively correlated with the resting whole saliva secretion rate. The number of hyposalivation-related medications used was not significantly correlated with the various whole saliva secretion rates. In nursing home residents, xerostomia, hyposalivation and using hyposalivation-related medications seem common and partially associated features

A facility to Search for Hidden Particles (SHiP) at the CERN SPS

A new general purpose fixed target facility is proposed at the CERN SPS accelerator which is aimed at exploring the domain of hidden particles and make measurements with tau neutrinos. Hidden particles are predicted by a large number of models beyond the Standard Model. The high intensity of the SPS 400~GeV beam allows probing a wide variety of models containing light long-lived exotic particles with masses below ${\cal O}$(10)~GeV/c$^2$, including very weakly interacting low-energy SUSY states. The experimental programme of the proposed facility is capable of being extended in the future, e.g. to include direct searches for Dark Matter and Lepton Flavour Violation.Comment: Technical Proposa

Saliva levels of Abeta1-42 as potential biomarker of Alzheimer's disease: a pilot study

<p>Abstract</p> <p>Background</p> <p>Simple, non-invasive tests for early detection of degenerative dementia by use of biomarkers are urgently required. However, up to the present, no validated extracerebral diagnostic markers for the early diagnosis of Alzheimer disease (AD) are available. The clinical diagnosis of probable AD is made with around 90% accuracy using modern clinical, neuropsychological and imaging methods. A biochemical marker that would support the clinical diagnosis and distinguish AD from other causes of dementia would therefore be of great value as a screening test. A total of 126 samples were obtained from subjects with AD, and age-sex-matched controls. Additionally, 51 Parkinson's disease (PD) patients were used as an example of another neurodegenerative disorder. We analyzed saliva and plasma levels of β amyloid (Aβ) using a highly sensitive ELISA kit.</p> <p>Results</p> <p>We found a small but statistically significant increase in saliva Aβ₄₂levels in mild AD patients. In addition, there were not differences in saliva concentration of Aβ₄₂between patients with PD and healthy controls. Saliva Aβ₄₀expression was unchanged within all the studied sample. The association between saliva Aβ₄₂levels and AD was independent of established risk factors, including age or Apo E, but was dependent on sex and functional capacity.</p> <p>Conclusions</p> <p>We suggest that saliva Aβ₄₂levels could be considered a potential peripheral marker of AD and help discrimination from other types of neurodegenerative disorders. We propose a new and promising biomarker for early AD.</p

A facility to Search for Hidden Particles (SHiP) at the CERN SPS

A new general purpose fixed target facility is proposed at the CERN SPS accelerator which is aimed at exploring the domain of hidden particles and make measurements with tau neutrinos. Hidden particles are predicted by a large number of models beyond the Standard Model. The high intensity of the SPS 400~GeV beam allows probing a wide variety of models containing light long-lived exotic particles with masses below ${\cal O}$(10)~GeV/c$^2$, including very weakly interacting low-energy SUSY states. The experimental programme of the proposed facility is capable of being extended in the future, e.g. to include direct searches for Dark Matter and Lepton Flavour Violation