CC3DML specification of initial generalized cell layout.

<p>CC3DML specification of initial generalized cell layout.</p

Python implementation of generalized-cell growth and death.

<p>Python implementation of generalized-cell growth and death.</p

Python implementation of updateAttributes function (continuation of Table 10) to randomly mutate cadherin expression levels.

<p>Python implementation of updateAttributes function (continuation of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0127972#pone.0127972.t010" target="_blank">Table 10</a>) to randomly mutate cadherin expression levels.</p

Emergent Stratification in Solid Tumors Selects for Reduced Cohesion of Tumor Cells: A Multi-Cell, Virtual-Tissue Model of Tumor Evolution Using CompuCell3D - Fig 1

<p><b>A</b>) Model cell-state transitions as a function of the glucose supply. As implemented in the simulation: (<b>B</b>) Flowchart for (Q)uiescent (S or C) cell transitions; (<b>C</b>) Flowchart for (P)roliferative (C)ancer cell transitions; (<b>D</b>) Flowchart for (P)roliferative (S)tem cell transitions.</p

Python implementation of cell-growth algorithm.

<p>Python implementation of cell-growth algorithm.</p

Number of Necrotic generalized cells as a function of time.

<p>In all replicas, the number of Necrotic generalized cells decreases after generalized cells begin to invade the stromal tissue.</p

Initial adhesion molecule density definition in CC3DML.

<p>Initial adhesion molecule density definition in CC3DML.</p

Steady state diffusion solver expressed in CC3DML

<p>Steady state diffusion solver expressed in CC3DML</p

Number of transient associations of 2, 3 and 4 generalized cells and clusters of five or more generalized cells as a function of time.

<p>The number of clusters increases continuously until it reaches the maximum the available space permits.</p

Python code selecting generalized cells which will undergo mitosis.

<p>Python code selecting generalized cells which will undergo mitosis.</p