Emergent Stratification in Solid Tumors Selects for Reduced Cohesion of Tumor Cells: A Multi-Cell, Virtual-Tissue Model of Tumor Evolution Using CompuCell3D - Fig 1

Abstract

<p><b>A</b>) Model cell-state transitions as a function of the glucose supply. As implemented in the simulation: (<b>B</b>) Flowchart for (Q)uiescent (S or C) cell transitions; (<b>C</b>) Flowchart for (P)roliferative (C)ancer cell transitions; (<b>D</b>) Flowchart for (P)roliferative (S)tem cell transitions.</p