Evolution of size-dependent flowering in Onopordum illyricum: A quantitative assessment of the role of stochastic selection pressures

We explore the evolution of delayed, size-dependent reproduction in the monocarpic perennial Onopordum illyricum, using a range of mathematical models, parameterized with long-term field data. Analysis of the long-term data indicated that mortality, flowering, and growth were age and size dependent. Using mixed models, we estimated the variance about each of these relationships and also individual-specific effects. For the held populations, recruitment was the main density-dependent process, although there were weak effects of local density on growth and mortality Using parameterized growth models, which assume plants grow along a deterministic trajectory, we predict plants should flower at sizes approximately 50% smaller than observed in the field. We then develop a simple criterion, termed the "1-yr look-ahead criterion," based on equating seed production now with that of next year, allowing for mortality and growth, to determine at what size a plant should flower. This model allows the incorporation of variance about the growth function and individual-specific effects. The model predicts flowering at sizes approximately double that observed, indicating that variance about the growth curve selects for larger sizes at flowering. The 1-yr look-ahead approach is approximate because it ignores growth opportunities more than 1 yr ahead. To assess the accuracy of this approach, we develop a more complicated dynamic state variable model. Both models give similar results indicating the utility of the 1-yr look-ahead criterion. To allow for temporal variation in the model parameters, we used an individual-based model with a generic algorithm. This gave very accurate prediction of the observed flowering strategies. Sensitivity analysis of the model suggested that temporal variation in the parameters of the growth equation made waiting to flower more risky, so selected for smaller sizes at flowering. The models clearly indicate the need to incorporate stochastic variation in life-history analyses

A comparison of sequential total and activated white cell count in patients undergoing coronary artery bypass grafting, using cardiopulmonary bypass, with and without a white cell filter

Introduction Cardiopulmonary bypass (CPB) has been shown to induce a systemic inflammatory response similar to the local reaction seen after tissue damage [1]. This leads to the release of toxic substances, such as elastase, which cause endothelial damage and may adversely affect outcome [2]. Use of a leucocyte depleting arterial line filter is one of many anti-inflammatory strategies that are undergoing evaluation. Leucocyte depleting filters may be capable of selectively removing activated white cells [3], but this has not been proved in vivo. The aim of the present study was to compare sequential total and activated white cells during CPB, using either a leucocyte depleting or standard arterial line filter. Materials and methods After local ethical committee approval, 20 patients undergoing coronary artery bypass grafting using CPB were prospectively randomly allocated to have either a Leukogard LG–6 (Pall Biomedical, Portsmouth, UK) or a nonleucocyte depleting filter inserted into the arterial line of the CPB circuit. Arterial limb blood samples were taken immediately after institution of CPB (0min) and at 10–min intervals throughout the bypass period. Activated white cells were identified using nitroblue tetrazolium, then both total and activated white cell numbers counted after staining with Leucoplate.Results Table 1 shows the number of white cells counted/1.25 ? l (volume of a single channel of Nageotte counting chamber) using light microscopy (× 25).Conclusion The LG6 leucocyte filter reduces the total white cell count and is capable of selectively removing activated white cells during CPB. The exact relationship between leucocyte depletion and improved patient outcome still remains unclear

The development of low temperature curing adhesives

An approach for the development of a practical low temperature (293 K-311 K/68 F-100 F) curing adhesive system based on a family of amide/ester resins was studied and demonstrated. The work was conducted on resin optimization and adhesive compounding studies. An improved preparative method was demonstrated which involved the reaction of an amine-alcohol precursor, in a DMF solution with acid chloride. Experimental studies indicated that an adhesive formulation containing aluminum powder provided the best performance when used in conjunction with a commercial primer

Lattice Model of Sweeping Interface for Drying Process in Water-Granule Mixture

Based on the invasion percolation model, a lattice model for the sweeping interface dynamics is constructed to describe the pattern forming process by a sweeping interface upon drying the water-granule mixture. The model is shown to produce labyrinthine patterns similar to those found in the experiment[Yamazaki and Mizuguchi, J. Phys. Soc. Jpn. \textbf{69} (2000) 2387]. Upon changing the initial granular density, resulting patterns undergo the percolation transition, but estimated critical exponents are different from those of the conventional percolation. Loopless structure of clusters in the patterns produced by the sweeping dynamics seems to influence the nature of the transition.Comment: 6 pages, 7 figure

The Anti-Coincidence Detector for the GLAST Large Area Telescope

This paper describes the design, fabrication and testing of the Anti-Coincidence Detector (ACD) for the Gamma-ray Large Area Space Telescope (GLAST) Large Area Telescope (LAT). The ACD is LAT first-level defense against the charged cosmic ray background that outnumbers the gamma rays by 3-5 orders of magnitude. The ACD covers the top and 4 sides of the LAT tracking detector, requiring a total active area of ~8.3 square meters. The ACD detector utilizes plastic scintillator tiles with wave-length shifting fiber readout. In order to suppress self-veto by shower particles at high gamma-ray energies, the ACD is segmented into 89 tiles of different sizes. The overall ACD efficiency for detection of singly charged relativistic particles entering the tracking detector from the top or sides of the LAT exceeds the required 0.9997.Comment: 33 pages, 19 figure

Perfect Reflection of Light by an Oscillating Dipole

We show theoretically that a directional dipole wave can be perfectly reflected by a single point-like oscillating dipole. Furthermore, we find that in the case of a strongly focused plane wave up to 85 % of the incident light can be reflected by the dipole. Our results hold for the full spectrum of the electromagnetic interactions and have immediate implications for achieving strong coupling between a single propagating photon and a single quantum emitter.Comment: 3 figure

Posterior parietal cortex guides visual decisions in rats

Neurons in putative decision-making structures can reflect both sensory and decision signals, making their causal role in decisions unclear. Here, we tested whether rat posterior parietal cortex (PPC) is causal for processing visual sensory signals or instead for accumulating evidence for decision alternatives. We optogenetically disrupted PPC activity during decision-making and compared effects on decisions guided by auditory vs. visual evidence. Deficits were largely restricted to visual decisions. To further test for visual dominance in PPC, we evaluated electrophysiological responses following individual sensory events and observed much larger response modulation following visual stimuli than auditory stimuli. Finally, we measured trial-to-trial spike count variability during stimulus presentation and decision formation. Variability sharply decreased, suggesting the network is stabilized by inputs, unlike what would be expected if sensory signals were locally accumulated. Our findings argue that PPC plays a causal role in processing visual signals that are accumulated elsewhere.SIGNIFICANCE STATEMENTDefining the neural circuits that support decision-making bridges a gap between our understanding of simple sensorimotor reflexes and our understanding of truly complex behavior. However, identifying brain areas which play a causal role in decision-making has proved challenging. We tested the causal role of a candidate component of decision circuits, the rat posterior parietal cortex (PPC). Our interpretation of the data benefitted from our use of animals trained to make decisions guided by either visual or auditory evidence. Our results argue that PPC plays a causal role specifically in visual decision-making, and that PPC may support sensory aspects of the decision, such as interpreting the visual signals so that evidence for a decision can be accumulated elsewhere

The Company Prosodic Deficits Keep Following Right Hemisphere Stroke: A Systematic Review

Objectives: The aim of this systematic review was to identify the presence and nature of relationships between specific forms of aprosodia (i.e., expressive and receptive emotional and linguistic prosodic deficits) and other cognitive-communication deficits and disorders in individuals with right hemisphere damage (RHD) due to stroke. Methods: One hundred and ninety articles from 1970 to February 2020 investigating receptive and expressive prosody in patients with relatively focal right hemisphere brain damage were identified via database searches. Results: Fourteen articles were identified that met inclusion criteria, passed quality reviews, and included sufficient information about prosody and potential co-occurring deficits. Twelve articles investigated receptive emotional aprosodia, and two articles investigated receptive linguistic aprosodia. Across the included studies, receptive emotional prosody was not systematically associated with hemispatial neglect, but did co-occur with deficits in emotional facial recognition, interpersonal interactions, or emotional semantics. Receptive linguistic processing was reported to co-occur with amusia and hemispatial neglect. No studies were found that investigated the co-occurrence of expressive emotional or linguistic prosodic deficits with other cognitive-communication impairments. Conclusions: This systematic review revealed significant gaps in the research literature regarding the co-occurrence of common right hemisphere disorders with prosodic deficits. More rigorous empirical inquiry is required to identify specific patient profiles based on clusters of deficits associated with right hemisphere stroke. Future research may determine whether the co-occurrences identified are due to shared cognitive-linguistic processes, and may inform the development of evidence-based assessment and treatment recommendations for individuals with cognitive-communication deficits subsequent to RHD