Application of Validated HPLC Method for Degradation Study of Sitagliptin and Metformin HCl

A novel and simple reverse phase liquid chromatographic method has been established for the determination of Sitagliptin and Metformin HCl and studies its degradation pattern in pharmaceutical dosage forms. Sitagliptin and Metformin HCl is used to control Type 2 Diabetes. The proposed work was performed on Younglin( S.K) isocratic System UV DetectorC18 column (150 mm 4.6 mm). A mixture of Potassium Phosphate buffer pH-3.2 with orthophosphoric acid and acetonitrile was used as mobile phase in this method with flow rate 0.7 ml/min (UV detection at 203 nm) and the method was validated as per ICH guidelines. Forced degradation studies were performed by exposing the drug Sitagliptin and Metformin HCl to acidic, alkaline, oxidation and thermal stress degradations. The proposed RP-HPLC method was found to be robust and specific and this method is suitable for the assay of pharmaceutical dosage forms as well as kinetic studies

Spectrum of abdominal organ injury in a primary blast type

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An Understanding of the Latest Pathophysiological Mechanisms of Pancreatic Cells in Diabetes

Beta cell multiplication happens because of insulin opposition during the advancement of diabetes. Since beta cells have a low limit with regards to generation, this compensatory multiplication could rush cell maturing and eventually cause diabetes. After beta cell development in lipoglucotoxicity, we checked out at the chance of cell senescence. High-fat eating routine incited diabetic C57BL/6J mice were read up for senescence-related beta cell markers. After 4 and 1 years of consuming a high-fat diet, intraperitoneal glucose resilience tests (IPGTTs), histochemical validation of Ki-67 and p38, senescence-associated -galactosidase, and -cell mass were conducted. There was a 2.2-overlay expansion in beta cell multiplication and a 3.1-overlap expansion in beta cell mass contrasted with the benchmark group following 4 months in the IPGTT. Following 1 year, AUC insulin was plainly lower, Ki-67-positive beta-cell repeat rate was 33% contrasted with the benchmark gathering, and senescence-related beta-galactosidase-positive region was 4.7 times higher than the benchmark bunch. about its necessity and its importance in the development of society are highlighte

Impact of Correlation and Pointing Error on Secure Outage Performance over Arbitrary Correlated Nakagami Turbulent Fading Mixed RF-FSO Channel

Funding Information: Manuscript received September 8, 2020; revised February 11, 2021; accepted February 14, 2021. Date of publication February 16, 2021; date of current version March 10, 2021. This research was supported in part by the National Research Foundation of Korea grant funded by the Korean government (Ministry of Science and ICT; 2019R1A2C1083988), in part by the Ministry of Science and ICT, Korea, under the Information Technology Research Center support program (IITP-2020-2016-0-00313) supervised by the Institute for Information & Communications Technology Planning & Evaluation, and in part by Sejong University through its faculty research program (20212023). (Sheikh Habibul Islam, A. S. M. Badrud-duza, and S. M. R. Islam contributed equally to this work and co-first authors.) Corresponding authors: A. S. M. Badrudduza; Heejung Yu (e-mail: [email protected]; [email protected]).)Peer reviewedPublisher PD

On the Intercept Probability and Secure Outage Analysis of Mixed (α-κ-μ)-Shadowed and Málaga Turbulent Models

This work was supported in part by the National Research Foundation of Korea-Grant funded by the Korean Government (Ministry of Science and ICT) under Grant NRF 2020R1A2B5B02002478, and in part by Sejong University through its Faculty Research Program under Grant 20212023Peer reviewedPublisher PD

Enhancing Physical Layer Secrecy Performance for RIS-assisted RF-FSO Mixed Wireless System

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Community-level interventions for pre-eclampsia (CLIP) in Pakistan: A cluster randomised controlled trial

Objectives: To reduce all-cause maternal and perinatal mortality and major morbidity through Lady Health Worker (LHW)-facilitated community engagement and early diagnosis, stabilization and referral of women with preeclampsia, an important contributor to adverse maternal and perinatal outcomes given delays in early detection and initial management.Study design: In the Pakistan Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomized controlled trial (NCT01911494), LHWs engaged the community, recruited pregnant women from 20 union councils (clusters), undertook mobile health-guided clinical assessment for preeclampsia, and referral to facilities after stabilization.Main outcome measures: The primary outcome was a composite of maternal, fetal and newborn mortality and major morbidity.Findings: We recruited 39,446 women in intervention (N = 20,264) and control clusters (N = 19,182) with minimal loss to follow-up (3∙7% vs. 4∙5%, respectively). The primary outcome did not differ between intervention (26·6%) and control (21·9%) clusters (adjusted odds ratio, aOR, 1∙20 [95% confidence interval 0∙84-1∙72]; p = 0∙31). There was reduction in stillbirths (0·89 [0·81-0·99]; p = 0·03), but no impact on maternal death (1·08 [0·69, 1·71]; p = 0·74) or morbidity (1·12 [0·57, 2·16]; p = 0·77); early (0·95 [0·82-1·09]; p = 0·46) or late neonatal deaths (1·23 [0·97-1·55]; p = 0·09); or neonatal morbidity (1·22 [0·77, 1·96]; p = 0·40). Improvements in outcome rates were observed with 4-7 (p = 0·015) and ≥8 (p \u3c 0·001) (vs. 0) CLIP contacts.Interpretation: The CLIP intervention was well accepted by the community and implemented by LHWs. Lack of effects on adverse outcomes could relate to quality care for mothers with pre-eclampsia in health facilities. Future strategies for community outreach must also be accompanied by health facility strengthening.Funding: The University of British Columbia (PRE-EMPT), a grantee of the Bill & Melinda Gates Foundation (OPP1017337)

Secrecy Performance Analysis of Mixed α - μ and Exponentiated Weibull RF-FSO Cooperative Relaying System

Funding Information: This work was supported in part by the National Research Foundation of Korea—Grant funded by the Korean Government under Grant Ministry of Science and ICT-NRF-2020R1A2B5B02002478, and in part by Sejong University through its Faculty Research Program under Grant 20212023.Peer reviewedPublisher PD

Secrecy Performance Analysis of Mixed Hyper-Gamma and Gamma-Gamma Cooperative Relaying System

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