On universality of local edge regime for the deformed Gaussian Unitary Ensemble

We consider the deformed Gaussian ensemble $H_n=H_n^{(0)}+M_n$ in which $H_n^{(0)}$ is a hermitian matrix (possibly random) and $M_n$ is the Gaussian unitary random matrix (GUE) independent of $H_n^{(0)}$. Assuming that the Normalized Counting Measure of $H_n^{(0)}$ converges weakly (in probability if random) to a non-random measure $N^{(0)}$ with a bounded support and assuming some conditions on the convergence rate, we prove universality of the local eigenvalue statistics near the edge of the limiting spectrum of $H_n$.Comment: 25 pages, 2 figure

Pluripolarity of Graphs of Denjoy Quasianalytic Functions of Several Variables

In this paper we prove pluripolarity of graphs of Denjoy quasianalytic functions of several variables on the spanning se

On the correlation function of the characteristic polynomials of the hermitian Wigner ensemble

We consider the asymptotics of the correlation functions of the characteristic polynomials of the hermitian Wigner matrices $H_n=n^{-1/2}W_n$. We show that for the correlation function of any even order the asymptotic coincides with this for the GUE up to a factor, depending only on the forth moment of the common probability law $Q$ of entries $\Im W_{jk}$, $\Re W_{jk}$, i.e. that the higher moments of $Q$ do not contribute to the above limit.Comment: 20

РАСЧЕТ КООРДИНАТ ГЕОМЕТРИЧЕСКОГО ЦЕНТРА КОЛЕСА АВТОМОБИЛЯ

The paper describes a necessity to take into account toe-in angles while making calculations of suspension kinematics. An algorithm for determination of vehicle wheel center coordinates with due account of camber and toe-in angles is presented with the help of turn matrices.  The obtained formulas describing functional dependence of vehicle wheel centre coordinates on camber and toe-in angles allow to reduce a general error in calculations and mathematical models for  operation of running gear and steering mechanisms.Отображена необходимость учета углов схождения колес при расчетах кинематики подвески, с использованием матриц поворота представлен алгоритм для определения координат центра колеса автомобиля с учетом углов развала и схождения. Полученные формулы, характеризующие функциональную зависимость координат центра колеса от углов развала и схождения, позволяют уменьшить общую погрешность в расчетах и математических моделях роботы ходовой части и механизмов рулевого управления автомобиля

VALVULAR BRONCHIAL CLOSURE IN THE TREATMENT OF BRONCHOPLEURAL FISTULAS

Aim of the study: the use of the valvular bronchial blocking technique in the treatment of bronchopleural fistulas in patients with thoracic pathology. Material and methods. During the period from 2012 to 2017, the valvular bronchial blocking technique was used in the treatment of 76 patients with bronchopleural fistulae (men 68, women 8). The age of patients is 16 to 82 years. In 24 patients, the indication for bronchial blocking was complications of thoracoscopic operations with bullous pulmonary emphysema. In a smaller number of cases (21), pneumothorax occurred in patients with COPD. Purulent diseases of the lungs and pleura caused a blockage in 24 patients. Results. Medlung blockers were used to treat patients. The blocker was placed in the "targeted" bronchus under local anesthesia while performing fibroblochoscopy. In all cases, the blocker was established. Reduction or cessation of air leakage through drainage from the pleural cavity occurred within a period of 5 hours to 1.5 days. In patients with poorly positive dynamics, correction of the blocker standing and additional blocking were performed, which resulted in good outcomes in 4 patients. A positive result was obtained in more than 85 % of patients. In 10 cases, no effect was obtained, which required surgical intervention. The duration of the blocker in the bronchus was from 4 days to 4 months. When removing the blocker, there were no complications. Conclusion. The technique of valvular bronchial blocking allowed to improve the results of treatment of patients with thoracic profile with various diseases complicated by the appearance of bronchopleural fistula, including complications of the postoperative period

EVALUATION OF THE LEVEL OF QUALITY OF LIFE IN PATIENTS WITH BULLOUS EMPHYSEMA OF THE LUNGS AFTER SURGICAL TREATMENT

The purpose of the study was to assess the level of quality of life in the postoperative period in patients with bullous emphysema of the lungs operated on by «open» access and using minimally invasive technologies using the SF-36 questionnaire. Material and methods. The results of a survey of 50 patients with bullous emphysema were analyzed. The patients were separated into 2 groups depending on the method of access. The first group (main) consisted of the patients underwent video-assisted thoracoscopy, resection of a bulla-modified lung tissue, subtotal parietal pleurectomy. The second group (comparison) consisted of the patients underwent thoracotomy, resection of a bulla-modified lung tissue, subtotal parietal pleurectomy. The survey was conducted using the SF-36 quality of life questionnaire for 1, 3, 6 and 12 months. Results and discussion. The main indicators of the quality of life of respondents in terms of 1, 3 and 6 months after the intervention were statistically significantly higher in the group of patients who underwent thoracoscopy. Only a year after the operation, the main indicators of the questionnaire were not statistically significantly different between groups of patients, but the indicators of vital activity, social functioning, mental health and psychological component of health remained significantly higher in patients of group 1. The results indicate the need for long-term postoperative rehabilitation of patients with bullous emphysema lungs, operated in an «open» way. Follow-up survey with the specific questionnaires is required for more detailed assessment of the level of quality of life in patients with thoracic organs pathology

Evaluation of the results of applying the early installation of the bronchial valve, prolonged air leakage in the early postoperative period in patients with bullous emphysema

The material was collected in the course of a retrospective study of the medical documentation of the Department of thoracic surgery of the SBU NSO state Novosibirsk regional clinical hospital. During the period from 2009 to 2017, 140 patients with bullous lung emphysema were included in the study, who underwent bull excision or apparatus resection of the lung area and Subtotal parietal pleurectomy. The patients ' age ranged from 15 to 60 years and averaged 29.46 years(Me 27 (23.0;34.0)). At the same time, 108 patients, which accounted for more than 70% were patients aged 21 to 40 years, i.e. the most able-bodied age. One of the serious complications in the postoperative period was air leakage through pleural drains. Proposed and implemented in the practice of the surgical thoracic Department method of early (2-3 days postoperative) drug resistant patients with discharge air and the analysis of the results of this method in comparison with late (more than 3 days since the operation) bronchomalacia. To do this, patients were divided into 2 groups. The first group included 11 patients to whom the bronchoblocker was installed later than 3 days after the intervention. The second group included 21 patients who had the blocker installed on 2-3 days of the postoperative period. There were no statistically significant differences between the groups by age, sex, method of influence on the bullous-altered fragment of pulmonary tissue (p>0.05).Материал собран в ходе ретроспективного исследования медицинской документации отделения торакальной хирургии ГБУЗ НСО Государственная Новосибирская областная клиническая больница. За период с 2009 по 2017 годы в исследование было включено 140 пациентов с буллезной эмфиземой легких, которым выполнена иссечение булл или аппаратная резекция участка легкого и субтотальная париетальная плеврэктомия. Возраст пациентов находился в диапазоне от 15 до 60 лет и в среднем значении составил 29,46 лет (Ме 27(23,0;34,0)). При этом 108 пациентов, что составляло более 70% были пациенты в возрасте от 21 до 40 лет, т.е. наиболее трудоспособного возраста. одним из грозных осложнений в послеоперационном периоде явилась утечка воздуха по плевральным дренажам. Предложен и внедрен в практику хирургического торакального отделения метод ранней (на 2-3 сутки послеоперационного периода) бронхоблокации у пациентов со сбросом воздуха и проведен анализ результатов этого метода в сравнении с поздней (более чем 3 суток с момента операции) бронхоблокацией. для этого пациенты были разделены на 2 группы. В первую группу включены 11 пациентов, которым бронхоблокатор был установлен позднее 3 суток после вмешательства. Во вторую группу были включены 21 пациент, которым блокатор устанавливался на 2-3 сутки послеоперационного периода. Статистически значимых различий между группами по возрасту, полу, способу воздействия на буллезно-измененный фрагмент легочной ткани не выявлено (p>0,05)

Ocean convergence and the dispersion of flotsam

Floating oil, plastics, and marine organisms are continually redistributed by ocean surface currents. Prediction of their resulting distribution on the surface is a fundamental, long-standing, and practically important problem. The dominant paradigm is dispersion within the dynamical context of a nondivergent flow: objects initially close together will on average spread apart but the area of surface patches of material does not change. Although this paradigm is likely valid at mesoscales, larger than 100 km in horizontal scale, recent theoretical studies of submesoscales (less than ∼10 km) predict strong surface convergences and downwelling associated with horizontal density fronts and cyclonic vortices. Here we show that such structures can dramatically concentrate floating material. More than half of an array of ∼200 surface drifters covering ∼20 × 20 km2 converged into a 60 × 60 m region within a week, a factor of more than 105 decrease in area, before slowly dispersing. As predicted, the convergence occurred at density fronts and with cyclonic vorticity. A zipperlike structure may play an important role. Cyclonic vorticity and vertical velocity reached 0.001 s−1 and 0.01 ms−1, respectively, which is much larger than usually inferred. This suggests a paradigm in which nearby objects form submesoscale clusters, and these clusters then spread apart. Together, these effects set both the overall extent and the finescale texture of a patch of floating material. Material concentrated at submesoscale convergences can create unique communities of organisms, amplify impacts of toxic material, and create opportunities to more efficiently recover such material

Mechanisms controlling dissolved iron distribution in the North Pacific : a model study

Author Posting. © American Geophysical Union, 2011. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 116 (2011): G03005, doi:10.1029/2010JG001541.Mechanisms controlling the dissolved iron distribution in the North Pacific are investigated using the Biogeochemical Elemental Cycling (BEC) model with a resolution of approximately 1° in latitude and longitude and 60 vertical levels. The model is able to reproduce the general distribution of iron as revealed in available field data: surface concentrations are generally below 0.2 nM; concentrations increase with depth; and values in the lower pycnocline are especially high in the northwestern Pacific and off the coast of California. Sensitivity experiments changing scavenging regimes and external iron sources indicate that lateral transport of sedimentary iron from continental margins into the open ocean causes the high concentrations in these regions. This offshore penetration only appears under a scavenging regime where iron has a relatively long residence time at high concentrations, namely, the order of years. Sedimentary iron is intensively supplied around continental margins, resulting in locally high concentrations; the residence time with respect to scavenging determines the horizontal scale of elevated iron concentrations. Budget analysis for iron reveals the processes by which sedimentary iron is transported to the open ocean. Horizontal mixing transports sedimentary iron from the boundary into alongshore currents, which then carry high iron concentrations into the open ocean in regions where the alongshore currents separate from the coast, most prominently in the northwestern Pacific and off of California.This work was supported by the U.S. National Science Foundation (EF‐0424599)

Ezrin Is Highly Expressed in Early Thymocytes, but Dispensable for T Cell Development in Mice

Ezrin/radixin/moesin (ERM) proteins are highly homologous proteins that function to link cargo molecules to the actin cytoskeleton. Ezrin and moesin are both expressed in mature lymphocytes, where they play overlapping roles in cell signaling and polarity, but their role in lymphoid development has not been explored.We characterized ERM protein expression in lymphoid tissues and analyzed the requirement for ezrin expression in lymphoid development. In wildtype mice, we found that most cells in the spleen and thymus express both ezrin and moesin, but little radixin. ERM protein expression in the thymus was differentially regulated, such that ezrin expression was highest in immature thymocytes and diminished during T cell development. In contrast, moesin expression was low in early thymocytes and upregulated during T cell development. Mice bearing a germline deletion of ezrin exhibited profound defects in the size and cellularity of the spleen and thymus, abnormal thymic architecture, diminished hematopoiesis, and increased proportions of granulocytic precursors. Further analysis using fetal liver chimeras and thymic transplants showed that ezrin expression is dispensable in hematopoietic and stromal lineages, and that most of the defects in lymphoid development in ezrin(-/-) mice likely arise as a consequence of nutritional stress.We conclude that despite high expression in lymphoid precursor cells, ezrin is dispensable for lymphoid development, most likely due to redundancy with moesin