Comparative Crystallographic Analysis of Some Photoactive Furanocoumarins and Role of C-H…O, C-H…π & π… π Interaction in Their Supramolecular Structure

The compounds taken in this paper to make a comprehensive review are imperatorin, phellopterin, rutaretin, marmesin and bergapten. The aim of this research paper is to confirm the aromatic character of these compounds and to find the different type interactions responsible to assemble the molecules into supramolecular structure. The pyrone moiety of all these molecules is perfectly planar with maximum deviation of 0.009(2) . In all the crystals, molecules are linked by C-H…O hydrogen bonds, forming a three dimensional framework. Different structural motifs (chains, dimmers, rings, etc.) bonded with C-H…π and π…π interactions are analysed, which leads them into supramolecular structures

Comparative Crystallographic Analysis of Some Photoactive Furanocoumarins and Role of C-H…O, C-H… & … Interaction in Their Supramolecular Structure

651-656The compounds taken in this paper to make a comprehensive review are imperatorin, phellopterin, rutaretin, marmesin and bergapten. The aim of this research paper is to confirm the aromatic character of these compounds and to find the different type interactions responsible to assemble the molecules into supramolecular structure. The pyrone moiety of all these molecules is perfectly planar with maximum deviation of 0.009(2) . In all the crystals, molecules are linked by C-H…O hydrogen bonds, forming a three dimensional framework. Different structural motifs (chains, dimmers, rings, etc.)bonded with C-H…π and π…π interactions are analysed, which leads them into supramolecular structures

Supramolecular structure of phellopterin isolated from the roots of heracleum thomsoni: A furanocoumarin

808-812<span style="font-size:10.0pt;font-family: " times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";mso-bidi-font-family:="" mangal;mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-US">The crystal structure of phellopterin has been determined by X-ray diffraction method. The compound crystallizes in the triclinic space group P1 with unit cell parameters: a = 8.431(3) Å, b = 8.947(3) Å, c = 11.125(4) Å, α = 69.11(5)°, β = 71.13(5)º and γ = 78.04(5) º, Z = 2, V=737.9(4) Å3. The structure has been solved by direct methods and refined to reliability index of 0.059. The molecules of phellopterin are linked by paired C-H...O hydrogen bond. The face to face π... π stacking interactions link the planar tricyclic moiety with one another and pack in parallel arrangements.</span

Supramolecular structure of phellopterin isolated from the roots of heracleum thomsoni: A furanocoumarin

The crystal structure of phellopterin has been determined by X-ray diffraction method. The compound crystallizes in the triclinic space group P1 with unit cell parameters: a = 8.431(3) Å, b = 8.947(3) Å, c = 11.125(4) Å, α = 69.11(5)°, β = 71.13(5)º and γ = 78.04(5) º, Z = 2, V=737.9(4) Å3. The structure has been solved by direct methods and refined to reliability index of 0.059. The molecules of phellopterin are linked by paired C-H...O hydrogen bond. The face to face π... π stacking interactions link the planar tricyclic moiety with one another and pack in parallel arrangements

Crystallographic analysis of 1H, 4H-tetrahydro-8-methyl-quinolizino-(9,9a,1gh)coumarin

524-527The crystal structure of 1H,4H-tetrahydro-8-methyl-quinolizino-(9,9a,1gh)coumarin (C16H17NO2) has been determined by X-ray crystallographic techniques. The compound crystallizes in monoclinic space group P21/n with unit cell parameters: a = 8.657(5) Å, b = 10.251(5) Å, c = 14.508(5) Å, = 96.61(1)°, Z = 4, V = 1278.91(11) Å3. The structure has been solved by direct methods and refined upto reliability index of 4.8%. The fused benzene and pyrone rings are planar. Both the piperidine rings exist in distorted sofa conformation. The crystal structure is stabilized by C-H...O hydrogen bonds

A comparative crystallographic analysis of the X-ray structure of three cholest-based steroidal molecules

1855-1859The molecular and crystal structures of (+)-4-cholesten-3-one 1 cholesteryl chloroformate 2 and cholesteryl-caprylate 3 have been determined by using X-ray crystallographic and computational techniques. All the three compounds crystallize in the monoclinic space group P2₁ with unit cell parameters: a=10.683(5)Å, b=7.861(2), c=14.616(2), β=105.8(2)º for [1], a=12.294(2)Å, b=9.399(8), c=12.787(2), β=113.3(1)º for [2] and a = 12.778(9), b = 9.201(4), c = 14.063(6) Å, β = 93.85(4)º for [3]. The number of molecules per unit cell in case of each structure is 2. The final R-factor for [1] is 0.054, [2] 0.077 and [3] 0.068. Besides some interesting geometrical and structural features, all the three molecules exhibit C-H…O hydrogen bonding. A comparative crystallographic analysis of all the three molecules has been reported in this paper

Application of aptamers as molecular recognition elements in lateral flow assays for analytical applications

Owing to their ease in operation and fast turnaround time, lateral flow assays (LFAs) are increasingly being used as point-of-care diagnostic tests for a variety of analytes. In a majority of these LFAs, antibodies are used as a molecular recognition element. Antibodies have a number of limitations such as high batch-to-batch variation, poor stability, long development time, difficulty in functionalization and need for ethical approval and cold chain. All these factors pose a great challenge to scale up the antibody-based tests. In recent years, the advent of aptamer technology has made a paradigm shift in the point-of-care diagnostics owing to the various advantages of aptamers over antibodies that favour their adaptability on a variety of sensing platforms including the lateral flow. In this review, we have highlighted the advantages of aptamers over antibodies, suitability of aptamers for lateral flow platforms, different types of aptamer-based LFAs and various labels for aptamer-based LFAs. We have also provided a summary of the applications of aptamer technology in LFAs for analytical applications. </p