47 research outputs found
Machine studies for the development of storage cells at the ANKE facility of COSY
We present a measurement of the transverse intensity distributions of the
COSY proton beam at the target interaction point at ANKE at the injection
energy of 45 MeV, and after acceleration at 2.65 GeV. At 2.65 GeV, the machine
acceptance was determined as well. From the intensity distributions the beam
size is determined, and together with the measured machine acceptance, the
dimensions of a storage cell for the double-polarized experiments with the
polarized internal gas target at the ANKE spectrometer are specified. An
optimum storage cell for the ANKE experiments should have dimensions of 15mm x
20mm x 390mm (vertical x horizontal x longitudinal), whereby a luminosity of
about 2.5*10^29 cm^-2*s^-1 with beams of 10^10 particles stored in COSY could
be reached.Comment: 18 pages, 13 figures, 4 table
Proton--induced deuteron breakup at GeV energies with forward emission of a fast proton pair
A study of the deuteron breakup reaction with forward emission
of a fast proton pair with small excitation energy 3 MeV has been
performed at the ANKE spectrometer at COSY--J\"ulich. An exclusive measurement
was carried out at six proton--beam energies ~0.6,~0.7,~0.8,~0.95,~1.35,
and 1.9 GeV by reconstructing the momenta of the two protons. The differential
cross section of the breakup reaction, averaged up to over the cm
polar angle of the total momentum of the pairs, has been obtained. Since
the kinematics of this process is quite similar to that of backward elastic scattering, the results are compared to calculations based on a
theoretical model previously applied to the process.Comment: 17 pages including 6 figures and 1 table v2: minor changes; v3: minor
change of author list; v4: changes in accordance with referee remark
Forward K+ production in subthreshold pA collisions at 1.0 GeV
K+ meson production in pA (A = C, Cu, Au) collisions has been studied using
the ANKE spectrometer at an internal target position of the COSY-Juelich
accelerator. The complete momentum spectrum of kaons emitted at forward angles,
theta < 12 degrees, has been measured for a beam energy of T(p)=1.0 GeV, far
below the free NN threshold of 1.58 GeV. The spectrum does not follow a thermal
distribution at low kaon momenta and the larger momenta reflect a high degree
of collectivity in the target nucleus.Comment: 4 pages, 3 figure
Polarizing a stored proton beam by spin flip?
We discuss polarizing a proton beam in a storage ring, either by selective
removal or by spin flip of the stored ions. Prompted by recent, conflicting
calculations, we have carried out a measurement of the spin flip cross section
in low-energy electron-proton scattering. The experiment uses the cooling
electron beam at COSY as an electron target. The measured cross sections are
too small for making spin flip a viable tool in polarizing a stored beam. This
invalidates a recent proposal to use co-moving polarized positrons to polarize
a stored antiproton beam.Comment: 18 pages, 6 figure
Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis
Animal experiments and early phase human trials suggest that inhibition of factor XIa (FXIa) safely prevents venous thromboembolism (VTE), and specific murine models of sepsis have shown potential efficacy in alleviating cytokine storm. These latter findings support the role of FXI beyond coagulation. Here, we combine targeted proteomics, machine learning and bioinformatics, to discover associations between FXI activity (FXI:C) and the plasma protein profile of patients with VTE. FXI:C was measured with a modified activated partial prothrombin time (APTT) clotting time assay. Proximity extension assay-based protein profiling was performed on plasma collected from subjects from the Genotyping and Molecular Phenotyping of Venous Thromboembolism (GMP-VTE) Project, collected during an acute VTE event (n = 549) and 12-months after (n = 187). Among 444 proteins investigated, N = 21 and N = 66 were associated with FXI:C during the acute VTE event and at 12 months follow-up, respectively. Seven proteins were identified as FXI:C-associated at both time points. These FXI-related proteins were enriched in immune pathways related to causes of thrombo-inflammation, extracellular matrix interaction, lipid metabolism, and apoptosis. The results of this study offer important new avenues for future research into the multiple properties of FXI, which are of high clinical interest given the current development of FXI inhibitors
Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis
Animal experiments and early phase human trials suggest that inhibition of factor XIa (FXIa) safely prevents venous thromboembolism (VTE), and specific murine models of sepsis have shown potential efficacy in alleviating cytokine storm. These latter findings support the role of FXI beyond coagulation. Here, we combine targeted proteomics, machine learning and bioinformatics, to discover associations between FXI activity (FXI:C) and the plasma protein profile of patients with VTE. FXI:C was measured with a modified activated partial prothrombin time (APTT) clotting time assay. Proximity extension assay-based protein profiling was performed on plasma collected from subjects from the Genotyping and Molecular Phenotyping of Venous Thromboembolism (GMP-VTE) Project, collected during an acute VTE event (n = 549) and 12-months after (n = 187). Among 444 proteins investigated, N = 21 and N = 66 were associated with FXI:C during the acute VTE event and at 12 months follow-up, respectively. Seven proteins were identified as FXI:C-associated at both time points. These FXI-related proteins were enriched in immune pathways related to causes of thrombo-inflammation, extracellular matrix interaction, lipid metabolism, and apoptosis. The results of this study offer important new avenues for future research into the multiple properties of FXI, which are of high clinical interest given the current development of FXI inhibitors
COMPERA 2.0: A refined 4-strata risk assessment model for pulmonary arterial hypertension.
BACKGROUND: Risk stratification plays an essential role in the management of patients with pulmonary arterial hypertension (PAH). The current European guidelines propose a 3-strata model to categorise risk as low, intermediate, or high, based on the expected 1-year mortality. However, with this model, most patients are categorised as intermediate risk. We investigated a modified approach based on 4 risk categories with intermediate risk subdivided into intermediate-low and intermediate-high risk. METHODS: We analysed data from COMPERA, a European pulmonary hypertension registry, and calculated risk at diagnosis and first follow-up based on functional class (FC), 6 min walking distance (6 MWD) and serum levels of brain natriuretic peptide (BNP) or N-terminal fragment of pro-BNP (NT-proBNP), using refined cut-off values. Survival was assessed with Kaplan-Meier analyses, log-rank testing, and Cox proportional hazards models. RESULTS: Data from 1,655 patients with PAH were analysed. Using the 3-strata model, most patients were classified as intermediate risk (76.0% at baseline and 63.9% at first follow-up). The refined 4-strata risk model yielded a more nuanced separation and predicted long-term survival, especially at follow-up assessment. Changes in risk from baseline to follow-up were observed in 31.1% of the patients with the 3-strata model and in 49.2% with the 4-strata model. These changes, including those between the intermediate-low and intermediate-high strata, were associated with changes in long-term mortality risk. CONCLUSIONS: Modified risk stratification using a 4-strata model based on refined cut-off levels for FC, 6MWD and BNP/NT-proBNP was more sensitive to prognostically relevant changes in risk than the original 3-strata model