Measurements of Gamma-Ray Bursts (GRBs) with Glast

One of the scientific goals of the main instrument of GLAST is the study of Gamma-Ray Bursts (GRBs) in the energy range from ~20 MeV to ~300 GeV. In order to extend the energy measurement towards lower energies a secondary instrument, the GLAST Burst Monitor (GBM), will measure GRBs from ~10 keV to ~25 MeV and will therefore allow the investigation of the relation between the keV and the MeV-GeV emission from GRBs over six energy decades. These unprecedented measurements will permit the exploration of the unknown aspects of the high-energy burst emission and the investigation of their connection with the well-studied low-energy emission. They will also provide ne insights into the physics of GRBs in general. In addition the excellent localization of GRBs by the LAT will stimulate follow-up observations at other wavelengths which may yield clues about the nature of the burst sources.Comment: 6 pages, 2 figures, to be published in Baltic Astronomy - Proceedings of the minisymposium "Physics of Gamma-Ray Bursts", JENAM Conference, August 29-30, 2003, Budapes

COMPTEL Observations of AGN at MeV-Energies

The COMPTEL experiment aboard CGRO, exploring the previously unknown sky at MeV-energies, has so far detected 10 Active Galactic Nuclei (AGN): 9 blazars and the radio galaxy Centaurus A. No Seyfert galaxy has been found yet. With these results COMPTEL has opened the field of extragalactic Gamma-ray astronomy in the MeV-band.Comment: 4 pages, 2 figures including 1 color plot, to appear in the Proceedings of the 3rd INTEGRAL Workshop "The Extreme Universe", held in Taormina, Italy, 14-18 September 199

COMPTEL observations of the quasar PKS 0528+134 during the first 3.5 years of the CGRO mission

The COMPTEL observations of the blazar-type quasar PKS 0528+134 in the energy range 0.75 MeV to 30 MeV carried out between April 1991 and September 1994 have been analyzed. During the first two years PKS 0528+134 was most significantly detected at energies above 3 MeV. During the last year there is only evidence for the quasar at energies below 3 MeV indicating a spectral change. The time-averaged COMPTEL energy spectrum between 0.75 MeV and 30 MeV is well represented by a power-law shape. Spectra collected from different observational periods reveal different power-law shapes: a hard state during flaring observations reported by EGRET, and a soft state otherwise. The combined simultaneous EGRET and COMPTEL spectra indicate these two spectral states as well. During low intensisty gamma-ray phases no spectral break is obvious from the combined COMPTEL and EGRET measurements. For the gamma-ray flaring phases however, the combined COMPTEL and EGRET data require a spectral bending at MeV-energies. By fitting broken power-law functions the best-fit values for the break in photon index range between 0.6 and 1.7, and for the break energy between ~5 MeV and ~20 MeV. Because the flux values measured by COMPTEL below 3 MeV in both states are roughly equal, the observations would be consistent with an additional spectral component showing up during gamma-ray flaring phases of PKS 0528+134. Such a component could be introduced by e.g. a high-energy electron-positron population with a low-energy cutoff in their bulk Lorentz factor distribution. The multiwavelength spectrum of PKS 0528+134 for gamma-ray flaring phases shows that the major energy release across the entire electro-magnetic spectrum is measured at MeV-energies.Comment: 10 pages, 8 postscript figures, latex, to appear in: A&A 328, 33 (1997

INTEGRAL-RXTE observations of Cygnus X-1

We present first results from contemporaneous observations of Cygnus X-1 with INTEGRAL and RXTE, made during INTEGRAL's performance verification phase in 2002 November and December. Consistent with earlier results, the 3-250 keV data are well described by Comptonization spectra from a Compton corona with a temperature of kT~50-90 keV and an optical depth of tau~1.0-1.3 plus reflection from a cold or mildly ionized slab with a covering factor of Omega/2pi~0.2-0.3. A soft excess below 10 keV, interpreted as emission from the accretion disk, is seen to decrease during the 1.5 months spanned by our observations. Our results indicate a remarkable consistency among the independently calibrated detectors, with the remaining issues being mainly related to the flux calibration of INTEGRAL.Comment: 6 pages, 3 figures. Figs. 2 and 3 are best viewed in color. Accepted for publication in the INTEGRAL special edition of A&A

SPI observations of positron annihilation radiation from the 4th galactic quadrant: sky distribution

During its first year in orbit the INTEGRAL observatory performed deep exposures of the Galactic Center region and scanning observations of the Galactic plane. We report on the status of our analysis of the positron annihilation radiation from the 4th Galactic quadrant with the spectrometer SPI, focusing on the sky distribution of the 511 keV line emission. The analysis methods are described; current constraints and limits on the Galactic bulge emission and the bulge-to-disk ratio are presented.Comment: 4 pages, 2 figures, accepted for publication in the proceedings of the 5th INTEGRAL worksho

Estrogens Determine Adherens Junction Organization and E-Cadherin Clustering in Breast Cancer Cells via Amphiregulin

Estrogens play an important role in the development and progression of human cancers, particularly in breast cancer. Breast cancer progression depends on the malignant destabilization of adherens junctions (AJs) and disruption of tissue integrity. We found that estrogen receptor alpha (ER alpha) inhibition led to a striking spatial reorganization of AJs and microclustering of E-Cadherin (E-Cad) in the cell membrane of breast cancer cells. This resulted in increased stability of AJs and cell stiffness and a reduction of cell motility. These effects were actomyosindependent and reversible by estrogens. Detailed investigations showed that the ERa target gene and epidermal growth factor receptor (EGFR) ligand Amphiregulin (AREG) essentially regulates AJ reorganization and E-Cad microclustering. Our results not only describe a biological mechanism for the organization of AJs and the modulation of mechanical properties of cells but also provide a new perspective on how estrogens and anti-estrogens might influence the formation of breast tumors