Resurrecting an Old Place with a New Purpose

This thesis will be based on the environs of Petersburger Strasse, in East Berlin, Germany; the cluttered street and underutilized surroundings will be reinvented, by providing refurbished housing with mixed use ground floors all catering to the general public as well as the young entrepreneurs and artists of the neighborhood. Directly adjacent to House 68, my thesis project, a cultural center composed of both restored and new buildings will be located facing the nearby community park, providing galleries and flexible spaces for art performances, classes, public gatherings, all while reinforcing a place of importance and identity in the community. This thesis contends that an architectural expression, pulling from regional traditions, can heal a scarred environment; providing a sense of community while acting as a catalyst for future cultural traditions that can point the way to a more sustainable future

The Earned Income Tax Credit, Low-Income Workers, and the Legal Aid Community

The Earned Income Tax Credit ("EITC") is the largest U.S. welfare program, with twenty-four million low-income Americans receiving $60 billion of disbursals in 2009. Through the EITC, working Americans with little or no tax liability can receive up to nearly$6,000 in refundable tax credits each year. Over the past two decades, policymakers have increasingly favored the EITC over direct-transfer welfare programs, citing its lower administrative expense (as recipients “self-certify” by filing taxes) and incentives for recipients to work. Despite its political appeal, the EITC suffers deep structural flaws. Largely because EITC claimants have little guidance in navigating the difficult filing process, they are subject to high rates of IRS audits and rescission of benefits with penalties and interest. This proliferation of EITC-related controversies has created an immense need for legal assistance, yet low-income tax law largely remains a peripheral concern within the legal aid community. In this article, we suggest a comprehensive and achievable set of reforms that the IRS and legal services organizations can enact to improve the EITC’s efficacy and fairness.We first describe how the complexity of EITC eligibility criteria creates a tremendous burden for low-income Americans, as they frequently lack advice in tax filing and cannot afford legal representation in the event of a controversy with the IRS. We then outline measures that the IRS should implement to make the EITC more accessible and understandable to those qualifying for the credit, reducing the chance of an audit and loss of benefits. In particular, we focus on improving the tax filing process, making EITC audits more manageable for recipients, instituting less adversarial procedures for EITC-related Tax Court proceedings, and changing certain organizational structures within the IRS. Finally, we propose several practical ways that the legal aid community can enhance its support of EITC recipients confronting an IRS audit or Tax Court action. Most importantly, we argue that EITC assistance warrants greater Congressional funding and higher strategic and budgetary priority within legal aid organizations, given that the EITC is now far larger than the direct-transfer welfare programs on which legal aid lawyers have traditionally focused

The Synthesis and Antiviral Properties of 8- Amino-3- [(2 hydroxyethoxy)methyl]-1,2,4-triazolo- [4,3-a ]pyrazine

The preparation of 8-amino-3-[(2-hydroxyethoxy)methyl]-1,2,4- triazolo[4,3-a]pyrazine (IV) as an analogue of 9-[(2-hydroxyethoxy) methyl]guanine and 9-(S)-(2,3-dihydroxypropyl)adenine is described from the reaction of 3-chloro-2-hydrazinopyrazine (V) and ethyl 2-(2-acetoxyethoxy)thioacetimidate (IXg) followed by treatment with ammonia. Compound IV was found to lack antiviral properties towards herpes simplex I and II, vaccinia virus, vesicular stomatitis virus, measles, reovirus type 1, parainfluenza virus type 3, Sindbis virus, Coxsackie type B4 virus, and poliovirus type

Genome editing for inborn errors of metabolism: advancing towards the clinic

Abstract Inborn errors of metabolism (IEM) include many disorders for which current treatments aim to ameliorate disease manifestations, but are not curative. Advances in the field of genome editing have recently resulted in the in vivo correction of murine models of IEM. Site-specific endonucleases, such as zinc-finger nucleases and the CRISPR/Cas9 system, in combination with delivery vectors engineered to target disease tissue, have enabled correction of mutations in disease models of hemophilia B, hereditary tyrosinemia type I, ornithine transcarbamylase deficiency, and lysosomal storage disorders. These in vivo gene correction studies, as well as an overview of genome editing and future directions for the field, are reviewed and discussed herein

Detailed Performance Loss Analysis of Silicon Solar Cells using High-Throughput Metrology Methods

In this work, novel, high-throughput metrology methods are used to perform a detailed performance loss analysis of approximately 400 industrial crystalline silicon solar cells, all coming from the same production line. The characterization sequence includes a non-destructive transfer length method (TLM) measurement technique featuring circular TLM structures hidden within the busbar region of the cells. It also includes a very fast external quantum efficiency and reflectance measurement technique. More traditional measurements, like illuminated current-voltage, Suns-VOC, and photoluminescence imaging are also used to carry out the loss analysis. The variance of the individual loss parameters and their impact on cell performance are investigated and quantified for this large group of industrial solar cells. Some important correlations between the measured loss parameters are found. The nature of these distributions and correlations provide important insights about loss mechanisms in a cell and help prioritize efforts to optimize the performance of the production line.Comment: 5 pages, 6 figures, conferenc

Understanding the UK hospital supply chain in an era of patient choice

Author Posting © Westburn Publishers Ltd, 2011. This is a post-peer-review, pre-copy-edit version of an article which has been published in its definitive form in the Journal of Marketing Management, and has been posted by permission of Westburn Publishers Ltd for personal use, not for redistribution. The article was published in Journal of Marketing Management, 27(3-4), 401 - 423, doi:10.1080/0267257X.2011.547084 http://dx.doi.org/10.1080/0267257X.2011.547084The purpose of this paper is to investigate the UK hospital supply chain in light of recent government policy reform where patients will have, inter alia, greater choice of hospital for elective surgery. Subsequently, the hospital system should become far more competitive with supply chains having to react to these changes as patient demand becomes less predictable. Using a qualitative case study methodology, hospital managers are interviewed on a range of issues. Views on the development of the hospital supply chain in different phases are derived, and are used to develop a map of the current hospital chain. The findings show hospital managers anticipating some significant changes to the hospital supply chain and its workings as Patient Choice expands. The research also maps the various aspects of the hospital supply chain as it moves through different operational phases and highlights underlying challenges and complexities. The hospital supply chain, as discussed and mapped in this research, is original work given there are no examples in the literature that provide holistic representations of hospital activity. At the end, specific recommendations are provided that will be of interest to service to managers, researchers, and policymakers

Analysis of the infrared spectra of the peculiar post-AGB stars EPLyr and HD52961

Aim: We aim to study in detail the peculiar mineralogy and structure of the circumstellar environment of two binary post-AGB stars, EPLyr and HD52961. Both stars were selected from a larger sample of evolved disc sources observed with Spitzer and show unique solid-state and gas features in their infrared spectra. Moreover, they show a very small infrared excess in comparison with the other sample stars. Methods: The different dust and gas species are identified on the basis of high-resolution Spitzer-IRS spectra. We fit the full spectrum to constrain grain sizes and temperature distributions in the discs. This, combined with our broad-band spectral energy distribution and interferometric measurements, allows us to study the physical structure of the disc, using a self-consistent 2D radiative-transfer disc model. Results: We find that both stars have strong emission features due to CO_2 gas, dominated by ^{12}C^{16}O_2, but with clear ^{13}C^{16}O_2 and even ^{16}O^{12}C^{18}O isotopic signatures. Crystalline silicates are apparent in both sources but proved very hard to model. EP Lyr also shows evidence of mixed chemistry, with emission features of the rare class-C PAHs. Whether these PAHs reside in the oxygen-rich disc or in a carbon-rich outflow is still unclear. With the strongly processed silicates, the mixed chemistry and the low ^{12}C/^{13}C ratio, EP Lyr resembles some silicate J-type stars, although the depleted photosphere makes nucleosynthetic signatures difficult to probe. We find that the disc environment of both sources is, to a first approximation, well modelled with a passive disc, but additional physics such as grain settling, radial dust distributions, and an outflow component must be included to explain the details of the observed spectral energy distributions in both stars.Comment: 14 pages, accepted for publication by A&