A numerical study of the development of bulk scale-free structures upon growth of self-affine aggregates

During the last decade, self-affine geometrical properties of many growing aggregates, originated in a wide variety of processes, have been well characterized. However, little progress has been achieved in the search of a unified description of the underlying dynamics. Extensive numerical evidence has been given showing that the bulk of aggregates formed upon ballistic aggregation and random deposition with surface relaxation processes can be broken down into a set of infinite scale invariant structures called "trees". These two types of aggregates have been selected because it has been established that they belong to different universality classes: those of Kardar-Parisi-Zhang and Edward-Wilkinson, respectively. Exponents describing the spatial and temporal scale invariance of the trees can be related to the classical exponents describing the self-affine nature of the growing interface. Furthermore, those exponents allows us to distinguish either the compact or non-compact nature of the growing trees. Therefore, the measurement of the statistic of the process of growing trees may become a useful experimental technique for the evaluation of the self-affine properties of some aggregates.Comment: 19 pages, 5 figures, accepted for publication in Phys.Rev.

Dietary patterns, foods, and food groups : relation to late-life cognitive disorders

The limited efficacy of disease-modifying therapeutic strategies for mild cognitive impairment (MCI) and Alzheimer\u2019s dementia (AD) underscores the need for preventive measures to reduce the burden of late-life cognitive impairment. The aim of the present review article was to investigate the relationship among dietary patterns, foods, and food groups and late-life cognitive disorders considering the results of observational studies published in the last three years (2014-2016). In the last decade, the association between diet and cognitive function or dementia has been largely investigated. However, more recently, the National Institute on Aging-Alzheimer\u2019s Association guidelines for AD and cognitive decline due to AD pathology introduced some evidence suggesting a direct relation between diet and changes in the brain structure and activity. Several studies focused on the role of the dietary patterns on late-life cognition, with accumulating evidence that combinations of foods and nutrients into certain patterns may act synergistically to provide stronger health effects than those conferred by their individual dietary components. In particular, higher adherence to a Mediterranean-type diet was associated with decreased cognitive decline, although the Mediterranean diet (MeDi) combines several foods, micronutrients, and macronutrients already separately proposed as potential protective factors against dementia and MCI. Moreover, also other emerging healthy dietary patterns such as the Dietary Approach to Stop Hypertension (DASH) and the Mediterranean-DASH diet Intervention for Neurodegenerative Delay (MIND) diets were associated with slower rates of cognitive decline and significant reduction in AD rate. Furthermore, some foods or food groups traditionally considered harmful such as eggs and red meat have been partially rehabilitated, while there is still a negative correlation of cognitive functions with added sugars and trans fatty acids, nutrients also increasing the cardiovascular risk. This would suggest a genesis for the same damage for aging brain

Nutritional interventions in patients with Alzheimer’s disease and other late-life cognitive disorders

Given the impact of nutrition on neuroprotection largely investigated in observational studies, in the present article, we reviewed evidence from randomized clinical trials (RCTs) published in the last three years (2014-2016) exploring nutritional intervention efficacy in slowing cognitive impairment progression and achieving cognitive-related outcomes in patients aged 60 years and older with mild cognitive impairment (MCI), preclinical Alzheimer\u2019s disease (AD), prodromal AD, AD, unspecified dementia, and vascular dementia using different levels of investigation (i.e., medical food/nutraceutical supplementation/multidomain approach and dietary food/macro-and micronutrient approaches). From the reviewed RCTs, there was emerging evidence that nutritional intervention through medical food/nutraceutical supplementation (Fortasyn Connect\uae and another similar nutraceutical formulation) and multidomain approach improved magnetic resonance imaging findings and other cognitive-related biomarkers, but without clear effect on cognition in mild AD and MCI. Moreover, there was some evidence of a positive effect of antioxidant-rich foods (nuts) in improving specific cognitive domains and cognitive-related outcomes in MCI and mild-to-moderate dementia, but only in small samples. There was also convincing evidence for fatty acid supplementation, mainly n-3 polyunsaturated fatty acids (PUFAs), in improving specific cognitive domains and/or cognitive-related biomarkers in MCI and AD. Furthermore, antioxidant vitamin and trace element supplementations improved only cognitive-related outcomes and biomarkers, without effect on cognitive function in AD and MCI patients. Finally, high-dose B vitamin supplementation in AD and MCI patients improved cognitive outcomes but only in the subjects with a high baseline plasma n-3 PUFA, while folic acid supplementation had positive impact on specific cognitive domains

Multiparticle Biased DLA with surface diffusion: a comprehensive model of electrodeposition

We present a complete study of the Multiparticle Biased Diffusion-Limited Aggregation (MBDLA) model supplemented with surface difussion (SD), focusing on the relevance and effects of the latter transport mechanism. By comparing different algorithms, we show that MBDLA+SD is a very good qualitative model for electrodeposition in practically all the range of current intensities {\em provided} one introduces SD in the model in the proper fashion: We have found that the correct procedure involves simultaneous bulk diffusion and SD, introducing a time scale arising from the ratio of the rates of both processes. We discuss in detail the different morphologies obtained and compare them to the available experimental data with very satisfactory results. We also characterize the aggregates thus obtained by means of the dynamic scaling exponents of the interface height, allowing us to distinguish several regimes in the mentioned interface growth. Our asymptotic scaling exponents are again in good agreement with recent experiments. We conclude by discussing a global picture of the influence and consequences of SD in electrodeposition.Comment: 15 pages, 20 figures, accepted for publication in Physical Review

Dietary intervention and prevention of cognitive-related outcomes in healthy older adults without cognitive dysfunction

In the last decade, the association between diet and cognitive function/dementia has been largely investigated in observational studies, while there was a lack of evidence from randomized clinical trials (RCTs) on the prevention of late-life cognitive disorders though dietary intervention in cognitively healthy older adults. In the present article, we reviewed RCTs published in the last three years (2014-2016) exploring nutritional intervention efficacy in preventing the onset of late-life cognitive disorders and dementia in cognitively healthy subjects aged over 60 years using different levels of investigation (i.e., dietary pattern changes/ medical food/nutraceutical supplementation/multidomain approach and dietary macro-and micronutrient approaches). From the included RCTs, there was moderate evidence that intervention through dietary pattern changes, medical food/nutraceutical supplementation, and multidomain approach improved specific cognitive domains or cognitive-related blood biomarkers. Moreover, there was high evidence that protein supplementation improved specific cognitive domains. For fatty acid supplementation, mainly long-chain polyunsaturated fatty acids, there was emerging evidence suggesting an impact of this approach in improving specific cognitive domains, MRI findings, and/or cognitive-related biomarkers also in selected subgroups of older subjects although some results were conflicting. Moreover, there was convincing evidence of an impact of non-flavonoid polyphenol and flavonoid supplementations in improving specific cognitive domains and/or MRI findings. Finally, there was only low evidence suggesting efficacy of intervention with homocysteine-related vitamins in improving cognitive functions, dementia incidence, or cognitive-related biomarkers in cognitively healthy older subjects

Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both

Background and objective: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) mutually increase the risk of being present in the same patient, especially if older. Whether or not this coexistence may be associated with a worse prognosis is debated. Therefore, employing data derived from the REPOSI register, we evaluated the clinical features and outcomes in a population of elderly patients admitted to internal medicine wards and having COPD, HF or COPD + HF. Methods: We measured socio-demographic and anthropometric characteristics, severity and prevalence of comorbidities, clinical and laboratory features during hospitalization, mood disorders, functional independence, drug prescriptions and discharge destination. The primary study outcome was the risk of death. Results: We considered 2,343 elderly hospitalized patients (median age 81 years), of whom 1,154 (49%) had COPD, 813 (35%) HF, and 376 (16%) COPD + HF. Patients with COPD + HF had different characteristics than those with COPD or HF, such as a higher prevalence of previous hospitalizations, comorbidities (especially chronic kidney disease), higher respiratory rate at admission and number of prescribed drugs. Patients with COPD + HF (hazard ratio HR 1.74, 95% confidence intervals CI 1.16–2.61) and patients with dementia (HR 1.75, 95% CI 1.06–2.90) had a higher risk of death at one year. The Kaplan–Meier curves showed a higher mortality risk in the group of patients with COPD + HF for all causes (p = 0.010), respiratory causes (p = 0.006), cardiovascular causes (p = 0.046) and respiratory plus cardiovascular causes (p = 0.009). Conclusion: In this real-life cohort of hospitalized elderly patients, the coexistence of COPD and HF significantly worsened prognosis at one year. This finding may help to better define the care needs of this population

Sex-Differences in the Pattern of Comorbidities, Functional Independence, and Mortality in Elderly Inpatients: Evidence from the RePoSI Register

Background: The RePoSi study has provided data on comorbidities, polypharmacy, and sex dimorphism in hospitalised elderly patients. Methods: We retrospectively analysed data collected from the 2010, 2012, 2014, and 2016 data sets of the RePoSi register. The aim of this study was to explore the sex-differences and to validate the multivariate model in the entire dataset with an expanded follow-up at 1 year. Results: Among 4714 patients, 51% were women and 49% were men. The disease distribution showed that diabetes, coronary artery disease, chronic obstructive pulmonary disease, chronic kidney disease, and malignancy were more frequent in men but that hypertension, anaemia, osteoarthritis, depression, and diverticulitis disease were more common in women. Severity and comorbidity indexes according to the Cumulative Illness Rating Scale (CIRS-s and CIRS-c) were higher in men, while cognitive impairment, mood disorders, and disability in daily life measured by the Barthel Index (BI) were worse in women. In the multivariate analysis, BI, CIRS, and malignancy significantly increased the risk of death in men at the 1-year follow-up, while age was independently associated with mortality in women. Conclusions: Our study highlighted the relevance and the validity of our previous predictive model in the identification of sex dimorphism in hospitalised elderly patients underscoring the need of sex-personalised health-care

Le Cicladi e il mondo egeo. Seminario internazionale di studi (Roma, 19-21 Novembre 1992)

Contributi del volume: M. Guarducci, Apollo di Delfi o Apollo delio? Contributo alla storia di Naxos cicladica e siceliota - R. Etienne - E. Dourlot, Les Cyclades - D.U. Schilardi, Il tempio di Atena a Koukounaries e considerazioni sulla topografia di Paros nel VII sec. a.C. - M. Tiverios, La costituzione dell'antica Andros - C.A. Televantou, Andros: l'antico insediamento di Ipsili - L. Gasperini, Le Cicladi nelle fonti epigrafiche cirenaiche - A. Laronde, Les Cyrénéens dans les Cyclades du IVeme au Ier s. av. J. C. - S.N. Consolo Langher, Naxos nell'Egeo arcaico e nella colonizzazione «calcidese» dell'Occidente - V. Costa, Ligdami, Pisistrato e la fondazione della tirannide nassia - J.N. Coldstream, A Question of Cycladic Geometric Amphorae - L. Marangou, Minoa nell'età geometrica - Y. Kouraghios, Nuove indagini e scoperte nell'antica capitale di Paros - C. Talamo, Le Cicladi e l'anfizionia di Delo - A. Mazarakis Enian, Ricognizioni archeologiche nell'isola di Kithnos - E. Lanzillotta, Note di storiografia delia - E. Lanzillotta, Semo di Del

Le Cicladi e il mondo egeo. Seminario internazionale di studi (Roma, 19-21 Novembre 1992)

Contributi del volume: M. Guarducci, Apollo di Delfi o Apollo delio? Contributo alla storia di Naxos cicladica e siceliota - R. Etienne - E. Dourlot, Les Cyclades - D.U. Schilardi, Il tempio di Atena a Koukounaries e considerazioni sulla topografia di Paros nel VII sec. a.C. - M. Tiverios, La costituzione dell'antica Andros - C.A. Televantou, Andros: l'antico insediamento di Ipsili - L. Gasperini, Le Cicladi nelle fonti epigrafiche cirenaiche - A. Laronde, Les Cyrénéens dans les Cyclades du IVeme au Ier s. av. J. C. - S.N. Consolo Langher, Naxos nell'Egeo arcaico e nella colonizzazione «calcidese» dell'Occidente - V. Costa, Ligdami, Pisistrato e la fondazione della tirannide nassia - J.N. Coldstream, A Question of Cycladic Geometric Amphorae - L. Marangou, Minoa nell'età geometrica - Y. Kouraghios, Nuove indagini e scoperte nell'antica capitale di Paros - C. Talamo, Le Cicladi e l'anfizionia di Delo - A. Mazarakis Enian, Ricognizioni archeologiche nell'isola di Kithnos - E. Lanzillotta, Note di storiografia delia - E. Lanzillotta, Semo di Del

Biopsychosocial frailty and the risk of incident dementia: The Italian longitudinal study on aging

Introduction: Frailty is a critical intermediate status of the aging process including physical, cognitive, and psychosocial domains/phenotypes. We operationalized a new biopsychosocial frailty (BF) construct, estimating its impact on the risk of incident dementia and its subtypes. Methods: In 2171 older individuals from the population-based Italian Longitudinal Study on Aging (ILSA), we identified by latent class procedures the BF construct as the physical frail status plus at least one of the two items of the 30-item Geriatric Depression Scale impaired (items 3/10). Results: Over a 3.5-year follow-up, participants with BF showed an increased risk of overall dementia (hazard ratio [HR]: 2.16, 95% confidence interval [CI]:1.07-4.37), particularly vascular dementia (VaD) (HR: 3.21, 95% CI: 1.05-9.75). Similarly, over a 7-year follow-up, an increased risk of overall dementia (HR: 1.84, 95% CI: 1.06-3.20), particularly VaD (HR: 2.53, 95% CI: 1.08-5.91), was also observed. Discussion: In a large cohort of Italian older individuals without cognitive impairment at baseline, a BF model was a short- and long-term predictor of overall dementia, particularly VaD