Технология крепления выработок для камерных систем разработки с закладкой

Монография посвящена вопросам обоснования рациональных параметров крепления нарезных выработок в зонах влияния очистных камер для конкретных геотехнических условий Южно-Белозерского месторождения. В результате теоретических, лабораторных и промышленных исследований предложены технологические решения для анкерного крепления нарезных выработок как в сторону висячего и лежачего боков от очистных камер. Для студентов, научно-педагогических и научно-технических сотрудников высших учебных заведений, научно-исследовательских институтов и проектных организаций, а также инженерно-технических работников горнорудных предприятий.Монографія присвячена питанням обґрунтування раціональних параметрів кріплення нарізних виробок у зонах впливу очисних камер для конкретних геотехнічних умов Південно-Білозерського родовища. В результаті теоретичних, лабораторних і промислових досліджень запропоновані технологічні рішення щодо анкерного кріплення нарізних виробок в масиві навколо первинних очисних камер. Для студентів, науково-педагогічних і науково-технічних співробітників вищих навчальних закладів, науково-дослідних інститутів та проектних організацій, а також інженерно-технічних робітників гірничорудних підприємств

Формирование национальной системы РФ по пластиковым картам

The article is devoted to the formation of national system of bank cards in Russian Federation, it's structure and qualities

Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021)

This article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention?Acrylamide, a substance potentially carcinogenic in humans, represents a very prevalent contaminant in food and is also contained in tobacco smoke. Occupational exposure to higher concentrations of acrylamide was shown to induce neurotoxicity in humans. To minimize related risks for public health, it is vital to obtain data on the actual level of exposure in differently affected segments of the population. To achieve this aim, acrylamide has been added to the list of substances of concern to be investigated in the HBM4EU project, a European initiative to obtain biomonitoring data for a number of pollutants highly relevant for public health. This report summarizes the results obtained for acrylamide, with a focus on time-trends and recent exposure levels, obtained by HBM4EU as well as by associated studies in a total of seven European countries. Mean biomarker levels were compared by sampling year and time-trends were analyzed using linear regression models and an adequate statistical test. An increasing trend of acrylamide biomarker concentrations was found in children for the years 2014–2017, while in adults an overall increase in exposure was found to be not significant for the time period of observation (2000–2021). For smokers, represented by two studies and sampling for, over a total three years, no clear tendency was observed. In conclusion, samples from European countries indicate that average acrylamide exposure still exceeds suggested benchmark levels and may be of specific concern in children. More research is required to confirm trends of declining values observed in most recent years.This work received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations. The Norwegian Institute of Public Health (NIPH) contributed to the funding of the Norwegian Environmental Biobank (NEB). The laboratory measurements were partly funded by the Research Council of Norway through research projects (275903 and 268465).info:eu-repo/semantics/publishedVersio

Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies

This article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention?More than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children.This work has received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations. The Norwegian Institute of Public Health (NIPH) has contributed to the funding of the Norwegian Environmental Biobank (NEB). The laboratory measurements have partly been funded by the Research Council of Norway through research projects (275903 and 268465).info:eu-repo/semantics/publishedVersio

The Higgs as a Portal to Plasmon-like Unparticle Excitations

12 LaTeX pages, 2 figures.-- Published in: JHEP04(2008)028.-- Final full-text version available at: http://dx.doi.org/10.1088/1126-6708/2008/04/028.A renormalizable coupling between the Higgs and a scalar unparticle operator O_U of non-integer dimension d_U<2 triggers, after electroweak symmetry breaking, an infrared divergent vacuum expectation value for O_U. Such IR divergence should be tamed before any phenomenological implications of the Higgs-unparticle interplay can be drawn. In this paper we present a novel mechanism to cure that IR divergence through (scale-invariant) unparticle self-interactions, which has properties qualitatively different from the mechanism considered previously. Besides finding a mass gap in the unparticle continuum we also find an unparticle pole reminiscent of a plasmon resonance. Such unparticle features could be explored experimentally through their mixing with the Higgs boson.Work supported in part by the European Commission under the European Union through the Marie Curie Research and Training Networks “Quest for Unification” (MRTN-CT- 2004-503369) and “UniverseNet” (MRTN-CT-2006-035863); by the Spanish Consolider- Ingenio 2010 Programme CPAN (CSD2007-0042); by a Comunidad de Madrid project (P-ESP-00346) and by CICYT, Spain, under contracts FPA 2007-60252 and FPA 2005-02211

Mitochondrial CISD1 is a downstream target that mediates PINK1 and Parkin loss-of-function phenotypes

AbstractBackgroundParkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. Familial cases of PD are often caused by mutations of PTEN-induced kinase 1 (PINK1) and the ubiquitin ligase Parkin, both pivotal in maintaining mitochondrial quality control. CISD1, a homodimeric mitochondrial iron-sulfur-binding protein, is a major target of Parkin-mediated ubiquitination. Loss of CISD1 is associated with mitochondrial dysfunction, redox imbalance, and abnormal iron accumulation, all hallmark features of PD.MethodsTo elucidate a possible involvement of CISD1 in PD pathophysiology, we investigated its role in dopaminergic neurons from PINK1 mutation patients, in fibroblasts lacking CISD1 or expressing a CISD1 mutant lacking its iron/sulfur cluster, and inPink1andParkinmutant flies.ResultsIn both patient-derived dopaminergic neurons and inPink1mutant flies, we observed a heightened propensity of CISD1 to form dimers. This corresponded to the iron-depleted state of CISD1. Reintroducing a CISD1 mutant incapable of binding the iron-sulfur cluster into CISD1 knockout cells failed to rescue mitochondrial fragmentation and oxidative distress. When overexpressed in Drosophila, this mutant proved detrimental by disrupting the redox equilibrium. Complete loss ofCisd, the Drosophila orthologue of CISD1, rescued all detrimental effects of Pink1 loss of function on climbing ability, wing posture, dopamine levels, lifespan, and mitochondrial ultrastructure. InParkinmutant flies, additional loss ofCisdameliorated climbing and wing posture phenotypes, but did not mitigate the reduction in lifespan.ConclusionOur results suggest that Cisd operates downstream of Pink1 and, partially, Prkn, shedding light on PD pathophysiology and implicating CISD1 as a potential therapeutic target