J Community Psychol

This research investigated the relationship between alcohol outlet density (AOD) and life expectancy, as mediated by community violence and community disadvantage. We used linear regression models to assess bivariate and multivariate relationships. There was a negative bivariate association between liquor store density and average life expectancy (\u3b2\ua0=\ua0-7.3370, p\ua0<\ua00.001). This relationship was partially attenuated when controlling for community disadvantage and fully attenuated when controlling for community violence. Bars/taverns (i.e., on-premise) were not associated with average life expectancy (\u3b2\ua0=\ua0-0.589, p\ua0=\ua00.220). Liquor store density is associated with higher levels of community disadvantage and higher rates of violence, both of which are associated with lower life expectancies. Future research, potential intervention, and current related policies are discussed.R01CE002682/ACL HHS/United StatesP60 MD000214/MD/NIMHD NIH HHS/United States5P60MD000214-14/National Institute of Minority Health and Health Disparities/1U01CE001954-01A1/Centers for Disease Control and Prevention/U01 CE001954/CE/NCIPC CDC HHS/United StatesR01CE002682/Centers for Disease Control and Prevention/2019-07-01T00:00:00Z30506926PMC62872696419vault:3122

Racial residential segregation, socioeconomic disparities, and the White-Black survival gap.

ObjectiveTo evaluate the association between racial residential segregation, a prominent manifestation of systemic racism, and the White-Black survival gap in a contemporary cohort of adults, and to assess the extent to which socioeconomic inequality explains this association.DesignThis was a cross sectional study of White and Black men and women aged 35-75 living in 102 large US Core Based Statistical Areas. The main outcome was the White-Black survival gap. We used 2009-2013 CDC mortality data for Black and White men and women to calculate age-, sex- and race adjusted White and Black mortality rates. We measured segregation using the Dissimilarity index, obtained from the Manhattan Institute. We used the 2009-2013 American Community Survey to define indicators of socioeconomic inequality. We estimated the CBSA-level White-Black gap in probability of survival using sequential linear regression models accounting for the CBSA dissimilarity index and race-specific socioeconomic indicators.ResultsBlack men and women had a 14% and 9% lower probability of survival from age 35 to 75 than their white counterparts. Residential segregation was strongly associated with the survival gap, and this relationship was partly, but not fully, explained by socioeconomic inequality. At the lowest observed level of segregation, and with the Black socioeconomic status (SES) assumed to be at the White SES level scenario, the survival gap is essentially eliminated.ConclusionWhite-Black differences in survival remain wide notwithstanding public health efforts to improve life expectancy and initiatives to reduce health disparities. Eliminating racial residential segregation and bringing Black socioeconomic status (SES) to White SES levels would eliminate the White-Black survival gap

J Addict Med

Objectives:To identify the incidence, characteristics and factors associated with against medical advice (AMA) discharge among hospitalized patients with opioid use disorder (OUD) and injection related infections (e.g., endocarditis, osteomyelitis, epidural abscesses).Methods:This retrospective cohort study evaluated adults with OUD admitted to an academic medical center from 1/1/2016-7/1/2019 for an invasive injection related infection. Multivariable logistic regression was used to determine independent factors associated with AMA discharge.Results:Among 262 adults admitted with serious injection related infections and comorbid OUD, 138 received inpatient medications for opioid use disorder (MOUD). Univariate analysis showed a decreased odds ratio (OR) of AMA discharge when patients received MOUD inpatient (OR 0.55; 95% CI 0.34-0.91.). Adjusting for covariates associated with social determinants of health and other substance use, inpatient receipt of MOUD was associated with a decreased risk of AMA discharge (adjusted OR 0.49; 95% CI 0.028 \u2013 0.84).Conclusions:Among patients with OUD and serious injection related infections, inpatient initiation of MOUD is associated with decreased risk of AMA discharge.KL2 TR002346/TR/NCATS NIH HHSUnited States/L30 AI133778/AI/NIAID NIH HHSUnited States/T32 AI007172/AI/NIAID NIH HHSUnited States/U54 CK000609/CK/NCEZID CDC HHSUnited States/2022-04-01T00:00:00Z32804690PMC799526611163vault:4081

Ultra-slow Fatigue Crack Propagation in Metallic Alloys

AbstractThe influence of frequency (20kHz ultrasonic tests and conventional 20 to 35Hz tests) and environment (air and vacuum) on near-threshold fatigue crack propagation of three metallic alloys, Ti-6Al-4V, 2024-T351 and 12% Cr stainless steel is compared experimentally. The effective stress-intensity factor which is considered as the propagation driving force is determined from closure measurements or tests run at high R-ratio. Based on microfractographic observations, the results are discussed in terms of a preexisting model for intrinsic and environmentally assisted fatigue crack propagation

Non-reciprocal optical reflection from a bidimensional array of subwavelength holes in a metallic film

Using simulations and theoretical arguments we investigate the specular reflection of a perforated gold film deposited on a glass substrate. A square lattice of cylindrical holes is assumed to produce the periodic lateral corrugation needed to hybridize the surface plasmons with radiative states. It is shown that, contrasting transmission approaches, a knowledge of the reflection on either side of the film provides separate information on the gold-vacuum surface plasmons and on the gold-glass interface plasmons. Recent experimental data on a specific implementation of this system are reexamined; these show a good agreement between the measured reflections and the simulations in both directions of incident wave probes. This confirms the importance of taking into account the reflection asymmetry in the far-field assessment of surface plasmons properties.Comment: 4 pages, 3 figures. Published versio

Baseline anti-NS4a antibodies in combination with on-treatment quantitative HCV-RNA reliably identifies nonresponders to pegylated interferon-ribavirin combination therapy after 4 weeks of treatment

Background Early detection of nonresponders to hepatitis C therapy limits unnecessary exposure to treatment and its side-effects. A recent algorithm combining baseline anti-NS4a antibodies and on-treatment quantitative PCR identified nonresponders to a combination of interferon and ribavirin after 1 week of treatment. Aim To validate a stopping rule based on baseline anti-NS4a antibody levels and early on-treatment virological response in treatment-naive genotype 1 chronic hepatitis C patients treated with the current standard pegylated interferon and ribavirin combination therapy. Methods Eighty-nine genotype 1 patients from the Dynamically Individualized Treatment of hepatitis C Infection and Correlates of Viral/Host dynamics Study treated for 48 weeks with standard 180 mu g pegylated interferon (PEG-IFN)-alpha-2a (weekly) and ribavirin 1000-1200mg (daily) were analysed. Baseline anti-NS4a antibody enzyme-linked immunosorbent assay (NS4a AA 1687-1718) was performed on pretreatment serum. Hepatitis C virus-RNA was assessed at days 0, 1, 4, 7, 8, 15, 22, 29, weeks 6, 7, 8, 10, 12 and 6 weekly thereafter until end of treatment. Multiple regression logistic analysis was performed. Results Overall 54 of 89 (61%) patients achieved sustained virological response. A baseline anti-NS4a antibody titre less than 1/1250 correlated with absence of favourable initial viral decline according to variable response types (P=0.015). The optimal algorithm was developed using the combination of the absence of anti-NS4a Ab (= 100.000 IU/ml at week 4. This algorithm has a specificity of 43% and negative predictive value of 100% to detect nonresponse to standard PEG-IFN-alpha-2a and ribavirin therapy at fourth week of therapy (intention-to-treat analysis). Conclusion The decision to stop the therapy in genotype 1 chronic hepatitis C patients treated with PEG-IFN-alpha-2a and ribavirin can be confidently made after 4 weeks of treatment based on the absence of baseline anti-NS4a Ab and a week-4 hepatitis C virus-RNA above 100.000 IU/ml. Eur J Gastroenterol Hepatol 22:1443-1448 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins

Post-Intensive Care Unit Psychiatric Comorbidity and Quality of Life

The prevalence of psychiatric symptoms ranges from 17% to 44% in intensive care unit (ICU) survivors. The relationship between the comorbidity of psychiatric symptoms and quality of life (QoL) in ICU survivors has not been carefully examined. This study examined the relationship between psychiatric comorbidities and QoL in 58 survivors of ICU delirium. Patients completed 3 psychiatric screens at 3 months after discharge from the hospital, including the Patient Health Questionnaire-9 (PHQ-9) for depression, the Generalized Anxiety Disorder-7 (GAD-7) questionnaire for anxiety, and the Post-Traumatic Stress Syndrome (PTSS-10) questionnaire for posttraumatic stress disorder. Patients with 3 positive screens (PHQ-9 ≥ 10; GAD-7 ≥ 10; and PTSS-10 > 35) comprised the high psychiatric comorbidity group. Patients with 1 to 2 positive screens were labeled the low to moderate (low-moderate) psychiatric comorbidity group. Patients with 3 negative screens were labeled the no psychiatric morbidity group. Thirty-one percent of patients met the criteria for high psychiatric comorbidity. After adjusting for age, gender, Charlson Comorbidity Index, discharge status, and prior history of depression and anxiety, patients who had high psychiatric comorbidity were more likely to have a poorer QoL compared with the low-moderate comorbidity and no morbidity groups, as measured by a lower EuroQol 5 dimensions questionnaire 3-level Index (no, 0.69 ± 0.25; low-moderate, 0.70 ± 0.19; high, 0.48 ± 0.24; P = 0.017). Future studies should confirm these findings and examine whether survivors of ICU delirium with high psychiatric comorbidity have different treatment needs from survivors with lower psychiatric comorbidity

What can AI do for you?

Simply put, most organizations do not know how to approach the incorporation of AI into their businesses, and few are knowledgeable enough to understand which concepts are applicable to their business models. Doing nothing and waiting is not an option: Mahidar and Davenport (2018) argue that companies that try to play catch-up will ultimately lose to those who invested and began learning early. But how do we bridge the gap between skepticism and adoption? We propose a toolkit, inclusive of people, processes, and technologies, to help companies with discovery and readiness to start their AI journey. Our toolkit will deliver specific and actionable answers to the operative question: What can AI do for you