Karpal tünel sendromlu hastalarda elektrodiyagnostik tanı ile Washington Nöropatik Ağrı Ölçeği arasındaki ilişki

Objectives: We undertook this study to examine the relationships between clinical symptoms as evaluated by Washington Neuropathic Pain Scale (NPS) and electrodiagnostic classification in patients with carpal tunnel syndrome (CTS). Methods: Eighty patients with unilateral CTS were included in this study. After diagnosis of CTS by electromyography, all patients completed a 10-item questionnaire (NPS). Results: A statistically significant correlation between total NPS score and severity of CTS was found (p=0.013, r=0.276). Conclusion: The present study indicates that using NPS might be useful in evaluating the clinical outcome of patients with CTS

Effect of coronavirus-19 restrictions in male handball players:physical activity, sedentary behavior, and satisfaction with life

This experiment examined physical activity (PA), sitting time, and satisfaction with life (SL) in European (45%) and Middle Eastern and North African (MENA; 55%) handball players (n = 418; age: 25.6 ± 6.8 years; body mass: 88.1 ± 11.7 kg; height: 1.83 ± 0.08 m) during the coronavirus (COVID)-19 pandemic. The International Physical Activity (IPAQ) and Satisfaction of Life (LS) Questionnaires were administered. All PA variables (vigorous, moderate, walking, total PA) were negatively influenced, but no interaction effects (IE; region x time) were observed. Sitting time increased from 2.5 to 4.9 h∙weekday−1 (ηp2 = 0.80) and walking time decreased from 66.8 to 33.5 min∙day−1 (ηp2 = 0.83). Based on effect sizes (d), pre- to during-confinement reductions were similar between regions (MENA: d = 3.29; Europe: d = 3.41; IE: ηp2 = 0.01). The largest regional difference was in moderate PA (MENA: d = 1.88; Europe: d = 2.99; IE: ηp2 = 0.09). SL in the total sample reduced from 30.6 ± 2.02 to 13.9 ± 2.20 arbitrary units (AU). SL reduction was similar in both regions (dMENA = 8.44; dEUROPE = 8.06; IE: ηp2 = 0.01). To conclude, PA decreased during COVID-19 confinement, sitting time increased, and SL decreased irrespective of geographical region. These preliminary findings highlight risk of SL and physical inactivity during COVID-19 restrictions in 2021

Interleukin (IL)–12 and IL-23 Are Key Cytokines for Immunity against Salmonella in Humans

Patients with inherited deficiency of the interleukin (IL)–12/IL-23–interferon (IFN)–g axis show increased susceptibility to invasive disease caused by the intramacrophage pathogens salmonellae and mycobacteria. We analyzed data on 154 patients with such deficiency. Significantly more patients with IL-12/IL-23–component deficiency had a history of salmonella disease than did those with IFN-g–component deficiency. Salmonella disease was typically severe, extraintestinal, and caused by nontyphoidal serovars. These findings strongly suggest that IL-12/IL-23 is a key cytokine for immunity against salmonella in humans and that IL-12/IL-23 mediates this protective effect partly through IFN-g–independent pathways. Investigation of the IL-12/IL-23–IFN-g axis should be considered in patients with invasive salmonella disease

High-intensity interval training (HIIT) in hypoxia improves maximal aerobic capacity more than HIIT in normoxia:a systematic review, meta-analysis, and meta-regression

The present study aimed to determine the effect of high intensity interval training (HIIT) in hypoxia on maximal oxygen uptake (VO2max) compared with HIIT in normoxia with a Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)-accordant meta-analysis and meta-regression. Studies which measured VO2max following a minimum of 2 weeks intervention featuring HIIT in hypoxia versus HIIT in normoxia were included. From 119 originally identified titles, nine studies were included (n = 194 participants). Meta-analysis was conducted on change in (∆) VO2max using standardised mean difference (SMD) and a random effects model. Meta-regression examined the relationship between the extent of environmental hypoxia (fractional inspired oxygen [FiO2]) and ∆VO2max and intervention duration and ∆VO2max. The overall SMD for ∆VO2max following HIIT in hypoxia was 1.14 (95% CI = 0.56–1.72; p < 0.001). Meta-regressions identified no significant relationship between FiO2 (coefficient estimate = 0.074, p = 0.852) or intervention duration (coefficient estimate = 0.071, p = 0.423) and ∆VO2max. In conclusion, HIIT in hypoxia improved VO2max compared to HIIT in normoxia. Neither extent of hypoxia, nor training duration modified this effect, however the range in FiO2 was small, which limits interpretation of this meta-regression. Moreover, training duration is not the only training variable known to influence ∆VO2max, and does not appropriately capture total training stress or load. This meta-analysis provides pooled evidence that HIIT in hypoxia may be more efficacious at improving VO2max than HIIT in normoxia. The application of these data suggest adding a hypoxic stimuli to a period of HIIT may be more effective at improving VO2max than HIIT alone. Therefore, coaches and athletes with access to altitude (either natural or simulated) should consider implementing HIIT in hypoxia, rather than HIIT in normoxia where possible, assuming no negative side effects

Effects of plyometric and short sprint with change-of-direction training in male U17 soccer players

This project investigated the effect of adding 8 weeks of bi-weekly plyometric and short sprint with change-of-direction (PSSCoD) training into standard training for elite youth soccer players from Tunisia. A training group (n = 18; age: 16.6 ± 0.5 years; body mass: 63.2 ± 4.8 kg; stature: 1.73 ± 0.07 m; body fat: 11.2 ± 1.7%), and control group (n = 16; age: 16.6 ± 0.5 years; body mass: 63.6 ± 4.3 kg; height: 1.73 ± 0.06 m; body fat: 11.6 ± 1.5%) participated. The pre- and post-intervention measures were squat-jump (SJ), countermovement jump (CMJ), standing long jump (SLJ), 5 m and 20 m sprint, change-of-direction ability (4 × 5 m sprint test (S 4 × 5 m)), repeated sprint ability (RSA), and static balance (stork balance test). The training group displayed superior jump (all p < 0.05; d > 0.49), sprint (p < 0.05; d > 0.52), change-of-direction ability (p < 0.01; d = 0.78), RSA (p < 0.01; d > 0.70), and static balance (p < 0.05; d > 0.49) improvements. Adding bi-weekly PSSCoD improves the athletic performance of young soccer players

Differences in Health-Related Physical Fitness and Academic School Performance in Male Middle-School Students in Qatar: A Preliminary Study

This study examined the differences in the level of physical fitness and academic performance among male middle-school children based on different body status categories. A total of 69 male children [age: 12.4 ± 0.7 years; body mass: 58.5 ± 7.2 kg; height: 1.62 ± 0.09 m; and body mass index (BMI): 22.4 ± 3.3 kg/m2] participated and were divided into BMI age-adjusted groups (i.e., lowest, middle, and highest BMI). Height, mass, BMI, stork test of static balance, 10 and 15 m sprint as an indicator for speed, hand-grip strength test, agility T-half test, medicine ball throw (MBT), and the Yo-Yo Intermittent Recovery Test level 1 (Yo-Yo IR1) were assessed. School records were retrieved for grade point averages (GPA) of mathematics, science, and Arabic. We found significant group differences regarding anthropometric (height: = 0.24, mass: = 0.33, and BMI: = 0.66), physical (sprint 10 m: = 0.26), and academic (mathematics: = 0.19 and science: = 0.15) performance parameters. The largest difference (p 0.5) correlation between parameters of different dimensions (e.g., anthropometric vs. physical performance parameters) was found. In conclusion, the highest BMI group exhibited similar physical and academic performances than the lowest group. Thus, these data emphasize the importance and appropriateness to engage young Qatari schoolchildren in physical activity as it associates with superior academic performance

Effect of Coronavirus-19 Restrictions in Male Handball Players: Physical Activity, Sedentary Behavior, and Satisfaction with Life

This experiment examined physical activity (PA), sitting time, and satisfaction with life (SL) in European (45%) and Middle Eastern and North African (MENA; 55%) handball players (n = 418; age: 25.6 ± 6.8 years; body mass: 88.1 ± 11.7 kg; height: 1.83 ± 0.08 m) during the coronavirus (COVID)-19 pandemic. The International Physical Activity (IPAQ) and Satisfaction of Life (LS) Questionnaires were administered. All PA variables (vigorous, moderate, walking, total PA) were negatively influenced, but no interaction effects (IE; region x time) were observed. Sitting time increased from 2.5 to 4.9 h∙weekday−1 (ηp2 = 0.80) and walking time decreased from 66.8 to 33.5 min∙day−1 (ηp2 = 0.83). Based on effect sizes (d), pre- to during-confinement reductions were similar between regions (MENA: d = 3.29; Europe: d = 3.41; IE: ηp2 = 0.01). The largest regional difference was in moderate PA (MENA: d = 1.88; Europe: d = 2.99; IE: ηp2 = 0.09). SL in the total sample reduced from 30.6 ± 2.02 to 13.9 ± 2.20 arbitrary units (AU). SL reduction was similar in both regions (dMENA = 8.44; dEUROPE = 8.06; IE: ηp2 = 0.01). To conclude, PA decreased during COVID-19 confinement, sitting time increased, and SL decreased irrespective of geographical region. These preliminary findings highlight risk of SL and physical inactivity during COVID-19 restrictions in 2021

High-Intensity Interval Training (HIIT) in Hypoxia Improves Maximal Aerobic Capacity More Than HIIT in Normoxia: A Systematic Review, Meta-Analysis, and Meta-Regression

The present study aimed to determine the effect of high intensity interval training (HIIT) in hypoxia on maximal oxygen uptake (VO2max) compared with HIIT in normoxia with a Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)-accordant meta-analysis and meta-regression. Studies which measured VO2max following a minimum of 2 weeks intervention featuring HIIT in hypoxia versus HIIT in normoxia were included. From 119 originally identified titles, nine studies were included (n = 194 participants). Meta-analysis was conducted on change in (∆) VO2max using standardised mean difference (SMD) and a random effects model. Meta-regression examined the relationship between the extent of environmental hypoxia (fractional inspired oxygen [FiO2]) and ∆VO2max and intervention duration and ∆VO2max. The overall SMD for ∆VO2max following HIIT in hypoxia was 1.14 (95% CI = 0.56–1.72; p < 0.001). Meta-regressions identified no significant relationship between FiO2 (coefficient estimate = 0.074, p = 0.852) or intervention duration (coefficient estimate = 0.071, p = 0.423) and ∆VO2max. In conclusion, HIIT in hypoxia improved VO2max compared to HIIT in normoxia. Neither extent of hypoxia, nor training duration modified this effect, however the range in FiO2 was small, which limits interpretation of this meta-regression. Moreover, training duration is not the only training variable known to influence ∆VO2max, and does not appropriately capture total training stress or load. This meta-analysis provides pooled evidence that HIIT in hypoxia may be more efficacious at improving VO2max than HIIT in normoxia. The application of these data suggest adding a hypoxic stimuli to a period of HIIT may be more effective at improving VO2max than HIIT alone. Therefore, coaches and athletes with access to altitude (either natural or simulated) should consider implementing HIIT in hypoxia, rather than HIIT in normoxia where possible, assuming no negative side effects

Residual Type 1 Immunity in Patients Genetically Deficient for Interleukin 12 Receptor β1 (IL-12Rβ1): Evidence for an IL-12Rβ1–Independent Pathway of IL-12 Responsiveness in Human T Cells

Genetic lack of interleukin 12 receptor β1 (IL-12Rβ1) surface expression predisposes to severe infections by poorly pathogenic mycobacteria or Salmonella and causes strongly decreased, but not completely abrogated, interferon (IFN)-γ production. To study IL-12Rβ1–independent residual IFN-γ production, we have generated mycobacterium–specific T cell clones (TCCs) from IL-12Rβ1–deficient individuals. All TCCs displayed a T helper type 1 phenotype and the majority responded to IL-12 by increased IFN-γ production and proliferative responses upon activation. This response to IL-12 could be further augmented by exogenous IL-18. IL-12Rβ2 was found to be normally expressed in the absence of IL-12Rβ1, and could be upregulated by IFN-α. Expression of IL-12Rβ2 alone, however, was insufficient to induce signal transducer and activator of transcription (Stat)4 activation in response to IL-12, whereas IFN-α/IFN-αR ligation resulted in Stat4 activation in both control and IL-12Rβ1–deficient cells. IL-12 failed to upregulate cell surface expression of IL-18R, integrin α6, and IL-12Rβ2 on IL-12Rβ1–deficient cells, whereas this was normal on control cells. IL-12–induced IFN-γ production in IL-12Rβ1–deficient T cells could be inhibited by the p38 mitogen-activated protein kinase (MAP) kinase inhibitor SB203580 and the MAP kinase kinase (MEK) 1/2 inhibitor U0126, suggesting involvement of MAP kinases in this alternative, Stat4-independent, IL-12 signaling pathway

Perception of Size and Mass Relationships of Moving and Stationary Object in Collision Events in 10-to-11-Month-Old Infants

Around 5.5–6.5 months of age, infants first attend to object size and perceive its mass cues in simple collision events. Infants attend to the size of the moving object and expect a greater displacement following a collision with a large object and stationary object, and lesser displacement following a collision with a small object and stationary object. It has been proposed that infants of 6-to-7 months of age can differentiate between sizes of moving objects but do not perceive the size and mass relationships in simple collision events. The present two investigations aimed to investigate whether infants 10-to-11 months of age (N = 16) could perceive this relationship (experiment 1) and the reverse of this relationship (experiment 2) utilising the looking time paradigm. The reverse of this relationship entailed the circumstances in which the moving object size was kept constant, but the stationary object size varied (small or large). Results from these experiments revealed that infants did not differ in their looking times for size congruent and size incongruent distances in both conditions. Infants did not look longer at the incongruent test events that violated expectation. For that reason, we conclude infants of 10-to-11 months of age were unable to perceive size and mass associations in collision events in either direction (moving object or stationary object size)