Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Vivienda embera: espacio y cultura

Contiene mapas, esquemas, planos.spa: La vivienda de las comunidades in­dígenas Emberá-Catío que habitan actualmente en regiones tropicales húmedas del Departamento de An­tioquia constituye un elemento im­portante de identidad, que denota una conciencia de técnicas constructivas, materiales y significaciones manteni­das a través de generaciones por los Emberá

Vivienda embera: Espacio y cultura

La vivienda de las comunidades in­dígenas Emberá-Catío que habitan actualmente en regiones tropicales húmedas del Departamento de An­tioquia constituye un elemento im­portante de identidad, que denota una conciencia de técnicas constructivas, materiales y significaciones manteni­das a través de generaciones por los Emberá

Correspondencias e implicaciones del pensar ciudad :hacia una poética dela ciudad contemporánea. Espacio y lugar del conocimiento de lo urbano y lo territorial en las ciencias del hábitat.

IP 1118-13-471-98v.1. Informe final -- v.2. La institucion como unidad de analisis etnografico - semiotico del acontecimiento urbano / Fabian Beethoven Zuleta Ruiz, Nora Elena Mesa Sanchez,Atanasio Roldan Botero, Maria Cristina Ramirez Toro.produccion de conocimiento sobre la ciudad y lo urbano. --Medellin : Universidad Nacional de Colombia, 2000.; 1 videocasete VHS (ca. min.) : s col.;imaginarios / Ovidio Delgado Mahecha ... [et al.]. -- Medellin:Universidad Nacional de Colombia, 2001. -- p.; 24 cm. -- ISBN 9587010868 -- ARTICULO(S) EN REVISTA: Lapoetica y la significacion del lugar / Nora Elena;Mesa Sanchez. -- En: Anotacones sobre planeacion. -- No. 47 (nov. 2000); p. 15-24. -- ISSN 01206974 --;VIDEO(S): Seminario de Formacion en Investigacion (2000 sept.-dic. : Medellin). -- La investigacion en la;: Universidad Nacional de Colombia, 2001. -- 187 p. ; 29 cm. --ISBN 9589126251 -- CAPITULO(S) EN LIBRO: El;espacio publico a la re-ligancia, la socialidad y el nuevoparadigma estetico / Nora Elena Mesa Sanchez. -- p.;105-116. -- En: Textos: documentos de historia y teoria [6]. --Bogotá : Universidad Nacional de Colombia,;2002. -- 132 p. -- ISBN 9706622 -- Hacia una poetica del aciudad contemporanea : Medellin y sus contextos;territoriales / Nora Elena Mesa Sanchez. -- p. 203-216. --En:Espacio y territorios : razon, pasion e;narrativas y discursos sobre la ciudad : Medellin 1975-2001 /Nora Elena Mesa Sanchez ... [et al.] -- Medellin;LIBRO(S): La investigacion etnografica de una organizacionacademica / Fabian Beethoven Zuleta Ruiz ... [et;al.] -- Medellin : Pensar, 2001 -- 314 p ; 27 cm. -- ISBN9589126243 -- Ensayos sobre intervenciones estetico;poeticas en la ciudad : linea de investigacion en urbanistica/Jorge Sarquis ... [et al.] -- Medellin :;Universidad Nacional de Colombia, 2002. -- 157 p. ; 23 cm.--ISBN 9589126286 -- Vivencias, hablas, relatos

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective