Repellent Effect of Neem against the Cabbage Armyworm on Leaf Vegetables

We investigated the pest repellent effect of azadirachtin formulation and neem seed kernel oil cake. In laboratory tests, the repellent effect of komatsuna and spinach treated with azadirachtin formulation or neem seed kernel oil cake for 7 days on the feeding cabbage armyworm were evaluated. The feeding repellent effect of azadirachtin formulation treatment was equivalent to that of commercial biological pesticide, while the effect of neem seed kernel oil cake treatment was higher. This result clarified that neem seed kernel oil cake has a high feeding repellent effect against cabbage armyworms. In field tests, although the feeding percentage for komatsuna and spinach controls was 70%, that for komatsuna and spinach treated with azadirachtin formulation and neem seed kernel oil cake was about 40% and 30%, respectively. These laboratory and field test findings demonstrated that despite having an affect less than that of azadirachtin, neem seed kernel oil cake is a high effective feeding repellent

Bir kırmızı, bir sarı gül ve Gülbaba

Taha Toros Arşivi, Dosya Adı: Galatasarayİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN/0033

セカイ ジドウシャ セイゾウギョウ 2014ネンド カブカ セイチョウ ノ ジケイレツ ブンセキ

世界自動車製造企業175社の2014年度の株価成長について時系列分析する。株価上昇率の高い企業を発見するため，我々は従来の時系列データクラスタリング手法ではなく，上昇率の違いを抽出可能なAmplitude-based クラスタリング手法を用いた。これにより，2014年度の１年間では，インドの自動車製造業において株価上昇が顕著であることを発見した。次に，企業の規模を含めて2013年度から2014年度への業界全体の変動と会社固有の局所的な変動を解析するため，収益額PLBT 及び，売上高を用いて統計的形状分析shape analysis の手法による分析を行った。2013年度から2014年度の変動においては，PLBT よりも売上高の変化率が大きく，業界全体として成長をしており，上位と下位の企業の差は縮まる傾向にあることが分かった。また，株価上昇率が高いインドの企業は，全体のフォーメーションの中での位置は2014年度においては業界平均よりも下位に属し，MULTI SUZUKI INDIA を除いては相対的に見て成長率は平均に届いていないことが分かった。2014年度の動きの特徴として，インド自動車製造企業は規模は小さいが，株価上昇率で顕著な成長変動を示したことが抽出できた

シンサイゴ ノ トウホク ケイザイ フッコウ オ ケンイン スル ジュヨウ カブカ ジョウショウ キギョウ ノ web マイニング ニヨル ブンセキ

研究報

シンサイゴ ノ カブカ ジョウショウ キギョウ ノ WEB マイニング ニヨル ゲンイン ブンセキ

　我々は2011年3月の東日本大震災によって引き起こされた経済活動における事象の記録，震災という未曾有の経済的混乱の状況下での被害状況および復興のようすを，若い世代に伝えたいと考える。その一環として，本稿では意外な株価上昇の原因をwebマイニングにより探るケーススタディについて述べる。震災後，ほとんどの企業が株価下落となったが，大幅に株価が上昇した企業もあった。また，震災の影響でマイナス要因が多いのも関わらず，株価が上昇した企業もあった。我々は，そのような事例として，仙台市の酒のやまや，オリエンタルランドを例にとり，その株価上昇の原因をwebテキストマイニングによって分析した

Differentiation of hypertrophic chondrocytes from human iPSCs for the in vitro modeling of chondrodysplasias

iPS細胞から肥大軟骨細胞への誘導法を確立し、成長板疾患の病態再現に成功. 京都大学プレスリリース. 2021-02-26.Reprogramming children's cells to study cartilage diseases. 京都大学プレスリリース. 2021-02-26.Chondrodysplasias are hereditary diseases caused by mutations in the components of growth cartilage. Although the unfolded protein response (UPR) has been identified as a key disease mechanism in mouse models, no suitable in vitro system has been reported to analyze the pathology in humans. Here, we developed a three-dimensional culture protocol to differentiate hypertrophic chondrocytes from induced pluripotent stem cells (iPSCs) and examine the phenotype caused by MATN3 and COL10A1 mutations. Intracellular MATN3 or COL10 retention resulted in increased ER stress markers and ER size in most mutants, but activation of the UPR was dependent on the mutation. Transcriptome analysis confirmed a UPR with wide-ranging changes in bone homeostasis, extracellular matrix composition, and lipid metabolism in the MATN3 T120M mutant, which further showed altered cellular morphology in iPSC-derived growth-plate-like structures in vivo. We then applied our in vitro model to drug testing, whereby trimethylamine N-oxide led to a reduction of ER stress and intracellular MATN3

アジア ツウカ キキジ ノ ケイザイ コウドウ ニオケル フカクジツセイ ノ ケンショウ カイセツ

研究報

A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome

稀少遺伝性自己炎症性疾患: OTULIN関連自己炎症症候群の新たな病態を解明～既報の疾患に新たな視点を追加し、未診断患者の診断や炎症・細胞死研究の進展に期待～. 京都大学プレスリリース. 2024-04-25.OTULIN-related autoinflammatory syndrome (ORAS), a severe autoinflammatory disease, is caused by biallelic pathogenic variants of OTULIN, a linear ubiquitin-specific deubiquitinating enzyme. Loss of OTULIN attenuates linear ubiquitination by inhibiting the linear ubiquitin chain assembly complex (LUBAC). Here, we report a patient who harbors two rare heterozygous variants of OTULIN (p.P152L and p.R306Q). We demonstrated accumulation of linear ubiquitin chains upon TNF stimulation and augmented TNF-induced cell death in mesenchymal stem cells differentiated from patient-derived iPS cells, which confirms that the patient has ORAS. However, although the de novo p.R306Q variant exhibits attenuated deubiquitination activity without reducing the amount of OTULIN, the deubiquitination activity of the p.P152L variant inherited from the mother was equivalent to that of the wild-type. Patient-derived MSCs in which the p.P152L variant was replaced with wild-type also exhibited augmented TNF-induced cell death and accumulation of linear chains. The finding that ORAS can be caused by a dominant-negative p.R306Q variant of OTULIN furthers our understanding of disease pathogenesis

Human immune and gut microbial parameters associated with inter-individual variations in COVID-19 mRNA vaccine-induced immunity

COVID-19 mRNA vaccines induce protective adaptive immunity against SARS-CoV-2 in most individuals, but there is wide variation in levels of vaccine-induced antibody and T-cell responses. However, the mechanisms underlying this inter-individual variation remain unclear. Here, using a systems biology approach based on multi-omics analyses of human blood and stool samples, we identified several factors that are associated with COVID-19 vaccine-induced adaptive immune responses. BNT162b2-induced T cell response is positively associated with late monocyte responses and inversely associated with baseline mRNA expression of activation protein 1 (AP-1) transcription factors. Interestingly, the gut microbial fucose/rhamnose degradation pathway is positively correlated with mRNA expression of AP-1, as well as a gene encoding an enzyme producing prostaglandin E2 (PGE2), which promotes AP-1 expression, and inversely correlated with BNT162b2-induced T-cell responses. These results suggest that baseline AP-1 expression, which is affected by commensal microbial activity, is a negative correlate of BNT162b2-induced T-cell responses.journal articl

フーリエ ヘンカン ノ センケイオウヨウリロン ニ モトヅク カブカ ヘンドウ ヘノ エイキョウ ノ パターン ブンセキ

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