Characteristics of food allergy in children: National multicenter study

Conference: Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) Location: Lisbon, PORTUGAL Date: JUN 01-05, 2019Background : Food allergies impose a significant burden on the life of the child and the family. In this study, to determine the demographic characteristics of food allergies, we investigated the characteristics of patients with food allergies in different regions of Pediatric Allergy- Immunology departments in Turkey. Method : Turkey ' s National Study of Allergy and Clinical Immunology Society has conducted a Study Group on Food Allergies. 25 centers participated in this multicenter, cross- sectional and descriptive study.European Academy of Allergy and Clinical Immunolog

Prevention of iron deficiency anemia in premature babies

Prematüre bebeklerin demir eksikliğinden korunmalarında, ilave demire en uygun başlanma zamanının saptanması amacıyla Mart 1983 - Ağustos 1984 tarihleri arasında Uludağ Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Kliniğinde yapılan bu çalışmada 34 hafta veya daha düşük gestasyonel yaşa sahip 52 prematüre bebek üç gurupta olmak üzere incelendiler, I. Guruptaki bebeklere bir aylıkta, II. Gurup taki bebeklere iki aylıkta, III, Guruptaki bebeklere de üç aylıkta ila ve demir verilmeye başlandı. Bebekler aylık kontrollerde ağırlık ve gelişim yönünden, 1., 2., 3. ve 6. aylarda da hematolojik yönden tetkik edildiler. Ağırlık artımı yönünden yapılan değerlendirmede bebekler arasında anlamlı farklılık saptanmadı» Hematolojik tetkiklerde ise, hemoglobin ve hematokrit değerleri 3 «aydaki ölçümlerde en geç ila ve demir başlanan gurupta diğer guruplara oranla düşük bulundu. Ancak bu guruba da ilave demir başlandıktan sonra altıncı ayda yapılan tetkiklerde arada fark kalmadığı görüldü. Serum demiri yönünden 3.ayda I. ve III.Gurup arasında anlamlı fark bulundu ve bu fark ilave demir başlandığı halde altıncı ayda halâ devam ediyordu. Ayrıca transferrin satürasyonu yönünden de en düşük değerler ilave demire eti geç başlanan gurupta elde edildi. Ancak bu değerler normal değerlerin alt sınırlarındaydı. MCV değerleri de 6, ayda en geç ilave demir başlanan gurup ta en düşük olarak bulundu ve diğer guruplarla anlamlı olarak farklıydı» Ancak yine de 6. ayda elde edilen bu değerler normal sınırlar için deydi. Birinci ve ikinci ayda ilave demir başlanan guruplar arasında sonuçlar yönünden anlamlı farklılık bulunamadı, fakat yine de birinci ay demir başlanan gurupta daha iyi sonuçlar elde edildi

Patients eligible for modulator drugs: Data from cystic fibrosis registry of Turkey

OZCELIK, HAYRIYE UGUR/0000-0003-1587-5216; Yilmaz, Ozge/0000-0001-6051-5020; Cekic, Sukru/0000-0002-9574-1842; Harmanci, Koray/0000-0002-8494-648X; Emiralioglu, Nagehan/0000-0002-1405-8401; Sismanlar Eyuboglu, Tugba/0000-0001-7284-4999; Aslan, Ayse Tana/0000-0002-5360-8517; COBANOGLU, NAZAN/0000-0002-3686-2927WOS: 000535323700001PubMed: 32453906Background A better understanding of cystic fibrosis transmembrane conductance regulator biology has led to the development of modulator drugs such as ivacaftor, lumacaftor-ivacaftor, tezacaftor-ivacaftor, and elexacaftor-tezacaftor-ivacaftor. This cross-sectional study evaluated cystic fibrosis (CF) patients eligible for modulator drugs. Methods Data for age and genetic mutations from the Cystic Fibrosis Registry of Turkey collected in 2018 were used to find out the number of patients who are eligible for modulator therapy. Results of registered 1488 CF patients, genetic analysis was done for 1351. the numbers and percentages of patients and names of the drugs, that the patients are eligible for, are as follows: 122 (9.03%) for ivacaftor, 156 (11.54%) for lumacaftor-ivacaftor, 163 (11.23%) for tezacaftor-ivacaftor, and 57 (4.21%) for elexacaftor-tezacaftor-ivacaftor. Among 1351 genotyped patients total of 313 (23.16%) patients are eligible for currently licensed modulator therapies (55 patients were shared by ivacaftor and tezacaftor-ivacaftor, 108 patients were shared by lumacaftor-ivacaftor and tezacaftor-ivacaftor, and 22 patients were shared by tezacaftor-ivacaftor and elexacaftor-tezacaftor-ivacaftor groups). Conclusions the present study shows that approximately one-fourth of the registered CF patients in Turkey are eligible for modulator drugs. As, frequent mutations that CF patients have in Turkey are different from North American and European CF patients, developing modulator drugs effective for those mutations is necessary. Furthermore, as modulator drugs are very expensive currently, financial support of the government in developing countries like Turkey is noteworthy

Airborne pollen in European and Asian parts of Istanbul.

Pollen concentrations in the atmosphere of Istanbul, a city located between two continents, has been monitored for 1 year as part of a larger research program. The sampling sites were located in two different continents: the Asian part (AS) and the European part (EP). The sampling was performed in AS and EP of the city by using Hirst type volumetric method, and pollen grains of 58 and 62 taxa were identified in the two parts, respectively. The pollen spectrum reflected the floristic diversity of the region. The main pollen producers at the sites were characterized by some allergenic pollen and were identified as Cupressaceae/Taxaceae, Urticaceae, Pistacia sp., Quercus sp., Platanus sp., Fraxinus sp., and Xanthium sp. These pollen types contributed to the total pollen sum with a percentage of more than 80% at both monitoring sites. The highest amount of pollen grains was recorded in April. The greatest number of species was recorded in May, when 42 types (AS) and 44 types (EP) were present

Guideline for diagnosis and treament of food allergy in children by "academia of pediatric allergy and asthma society"

Food allergy is defined as type 1 hypersensitivity reaction of IgE antibodies against food proteins. As its frequency increases in the world, food allergy is becoming more common in our country. Infants, who have allergic rhinitis, bronchial asthma, atopic dermatitis and food allergy in their families, have a high risk of food allergy. Therefore defining a protocol will be helpful for correct diagnosis and treatment in high risk infants. The aim of this protocol prepared by "Academia of Pediatric Allergy and Asthma Society" is to asist the family physicians and pediatricians for the diagnosis and treatment of food allergy as a resource and guideline

A multi-center survey of childhood asthma in Turkey - I: The cost and its determinants

WOS: 000262517500013PubMed ID: 18363634Successful management of childhood asthma requires a thorough idea of the economic impact of asthma and its determinants, as policy makers and physicians inevitably influence the outcome. The aim of this study was to define the cost of childhood asthma in Turkey and its determinants. In April 2006, a multi-center, national study was performed where data regarding cost and control levels were collected. Asthmatic children (6-18 yr) with at least a 1-yr follow-up seen during a 1-month period with scheduled or unscheduled visits were included. The survey included a questionnaire-guided interview and retrospective evaluation of files. Cost and its determinants during the last year were analyzed. A total of 618 children from 12 asthma centers were surveyed. The total annual cost of childhood asthma was US$1597.4 +/- 236.2 and there was a significant variation in costs between study centers (p < 0.05). Frequent physician visits [odds ratio (95% confidence intervals)] [2.3 (1.6-3.4)], hospitalization [1.9 (1.1-3.3)], asthma severity [1.6 (1.1-2.8)], and school absenteeism due to asthma [1.5 (1.1-2.1)] were major predictors of total annual costs (p < 0.05 for each). The comparable cost of asthma among Turkish children with that reported in developed countries suggests that interventions to decrease the economic burden of pediatric asthma should focus on the cost-effectiveness of anti-allergic household measures and on improving the control levels of asthma