61 research outputs found
The Puzzle of the Flyby Anomaly
Close planetary flybys are frequently employed as a technique to place
spacecraft on extreme solar system trajectories that would otherwise require
much larger booster vehicles or may not even be feasible when relying solely on
chemical propulsion. The theoretical description of the flybys, referred to as
gravity assists, is well established. However, there seems to be a lack of
understanding of the physical processes occurring during these dynamical
events. Radio-metric tracking data received from a number of spacecraft that
experienced an Earth gravity assist indicate the presence of an unexpected
energy change that happened during the flyby and cannot be explained by the
standard methods of modern astrodynamics. This puzzling behavior of several
spacecraft has become known as the flyby anomaly. We present the summary of the
recent anomalous observations and discuss possible ways to resolve this puzzle.Comment: 6 pages, 1 figure. Accepted for publication by Space Science Review
Systems of Hess-Appel'rot type
We construct higher-dimensional generalizations of the classical
Hess-Appel'rot rigid body system. We give a Lax pair with a spectral parameter
leading to an algebro-geometric integration of this new class of systems, which
is closely related to the integration of the Lagrange bitop performed by us
recently and uses Mumford relation for theta divisors of double unramified
coverings. Based on the basic properties satisfied by such a class of systems
related to bi-Poisson structure, quasi-homogeneity, and conditions on the
Kowalevski exponents, we suggest an axiomatic approach leading to what we call
the "class of systems of Hess-Appel'rot type".Comment: 40 pages. Comm. Math. Phys. (to appear
Phenomenology of the Lense-Thirring effect in the Solar System
Recent years have seen increasing efforts to directly measure some aspects of
the general relativistic gravitomagnetic interaction in several astronomical
scenarios in the solar system. After briefly overviewing the concept of
gravitomagnetism from a theoretical point of view, we review the performed or
proposed attempts to detect the Lense-Thirring effect affecting the orbital
motions of natural and artificial bodies in the gravitational fields of the
Sun, Earth, Mars and Jupiter. In particular, we will focus on the evaluation of
the impact of several sources of systematic uncertainties of dynamical origin
to realistically elucidate the present and future perspectives in directly
measuring such an elusive relativistic effect.Comment: LaTex, 51 pages, 14 figures, 22 tables. Invited review, to appear in
Astrophysics and Space Science (ApSS). Some uncited references in the text
now correctly quoted. One reference added. A footnote adde
The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia
Focal cortical dysplasia (FCD) is one of the most common malformations causing refractory epilepsy. Dysregulation of glutamatergic systems plays a critical role in the hyperexcitability of dysplastic neurons in FCD lesions. The pharmacoresistant nature of epilepsy associated with FCD may be due to a lack of well tolerated and precise antiepileptic drugs that can target glutamate receptors. Here, for the first time in human FCD brain slices, we show that the established, non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, perampanel has potent antiepileptic action. Moreover, we demonstrate that this effect is due to a reduction in burst firing behavior in human FCD microcircuits. These data support a potential role for the treatment of refractory epilepsy associated with FCD in human patients
Human brain slices for epilepsy research:pitfalls, solutions and future challenges
Increasingly, neuroscientists are taking the opportunity to use live human tissue obtained from elective neurosurgical procedures for electrophysiological studies in vitro. Access to this valuable resource permits unique studies into the network dynamics that contribute to the generation of pathological electrical activity in the human epileptic brain. Whilst this approach has provided insights into the mechanistic features of electrophysiological patterns associated with human epilepsy, it is not without technical and methodological challenges. This review outlines the main difficulties associated with working with epileptic human brain slices from the point of collection, through the stages of preparation, storage and recording. Moreover, it outlines the limitations, in terms of the nature of epileptic activity that can be observed in such tissue, in particular, the rarity of spontaneous ictal discharges, we discuss manipulations that can be utilised to induce such activity. In addition to discussing conventional electrophysiological techniques that are routinely employed in epileptic human brain slices, we review how imaging and multielectrode array recordings could provide novel insights into the network dynamics of human epileptogenesis. Acute studies in human brain slices are ultimately limited by the lifetime of the tissue so overcoming this issue provides increased opportunity for information gain. We review the literature with respect to organotypic culture techniques that may hold the key to prolonging the viability of this material. A combination of long-term culture techniques, viral transduction approaches and electrophysiology in human brain slices promotes the possibility of large scale monitoring and manipulation of neuronal activity in epileptic microcircuits
Simulação dos efeitos das mudanças do uso da terra na dinùmica de carbono no solo na bacia do rio Piracicaba
Community and population dynamics of spruceÂfir forests on Whiteface Mountain, New York: recent trends, 1985Â2000
Nitrogen availability and forest productivity along a climosequence on Whiteface Mountain, New York
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