Direct photon production from hadronic sources in high-energy heavy-ion collisions

The low $p_T$ direct photon production from a variety of the hadronic sources is studied within the microscopic HSD transport approach for p+C, p+Pb and Pb+Pb collisions at 160 A GeV. The direct photon emission from elementary hadronic scatterings as well as meson-meson bremsstrahlung are incorporated. The influence of in-medium effects such as a collisional broadening of the vector-meson spectral functions on the photon emission rate is found to be hardly observable in the final spectra which are dominated by bremsstrahlung type processes. The uncertainties in the subtraction of the 'background' from the photon decay of hadronic resonances inside the hot and dense fireball is investigated, additionally. Our findings are relevant for the interpretation and extraction of experimental data on direct photon production at low $p_T$.Comment: 25 pages, 10 figures, to be published in Phys. Rev.

Использование шовного материала с триклозановым покрытием как профилактика инфекций области хирургического вмешательства (обзор литературы)

According to international data, the incidence of infections in the field of surgery in children and adults varies from 2.0 to 20.0 %. The occurrence of the above infections is influenced by many factors: the presence of comorbidities, ASA index, surgical wound class, NNIS risk index. Important factors include the quality of the suture. According to experts of the World Health Organization, 40.0–60.0 % of infections in the field of surgery can be prevented. The first microbiological study of suture (polyglactin 910) with triclosan was published in 2002. According to international studies, the use of a triclosan reduces the adhesion of bacteria to the suture, the viability of microbes and the release of inflammatory mediators. Triclosan actively prevents the colonization of the filament, in addition, concentrations sufficient to suppress the growth and reproduction of pathogens are maintained in the environment for a long time, resulting in the prevention of the development of infectious complications.По международным данным, частота развития инфекций области хирургического вмешательства у детей и взрослых варьирует от 2,0 до 20,0 %. На возникновение этих инфекций влияет множество факторов: наличие сопутствующих заболеваний, индекс ASA, класс хирургической раны, индекс риска NNIS, а также качество шовного материала. По оценкам специалистов Всемирной организации здравоохранения, 40,0–60,0 % инфекций области хирургического вмешательства можно предотвратить. Первое микробиологическое исследование шовного материала (полиглактин 910) с триклозаном было опубликовано в 2002 г. По данным международных исследований, использование триклозана снижает адгезию бактерий к шовному материалу, а также жизнеспособность микробов и высвобождение медиаторов воспаления. Триклозан активно препятствует колонизации нити. Кроме того, в течение длительного времени в окружающей среде поддерживаются концентрации, достаточные для подавления роста и размножения патогенов, следствием чего становится предупреждение развития инфекционных осложнений

CERN PS laser ion source development

CERN, together with ITEP and TRINITI (Russia), is developing a CO2 laser ion source. The key design parameters are: 1.4 1010 ions of Pb25+ in a pulse of 5.5 ms, with a 4-rms emittance of 0.2 10-6 rad m, working at a repetition rate of 1 Hz. This device is considered as one candidate source for LHC heavy ion operation. The status of the laser development, the experimental set-up of the source consisting of the target area and its illumination, the plasma expansion area and extraction, beam transport and ion pre-acceleration by an RFQ, will be given

Growth of SiC films by the method of substitution of atoms on porous Si (100) and (111) substrates

The mechanisms of growth of silicon carbide (SiC) films by the method of substitution of atoms on macro- and mesoporous silicon substrates (Si) of p- and n-type conduction are investigated. Significant dependence of the rate and the mechanism of nucleation of SiC layers on Si on the type of Si doping and its crystallographic orientation is experimentally found. Comparison of the experimental data with the theoretical results obtained earlier is performed. It is shown that the presence of the system of pores on the surface allows one to significantly increase the thickness of silicon transformed into SiC during the process of synthesis by the method of substitution of atoms, which was equal to 115 microns in our experiments. The obtained samples are studied by methods of scanning electron microscopy, micro-Raman spectroscopy, and X-ray diffraction analysis. Numerical simulation of the distribution of elastic stresses caused by the difference in thermal expansion coefficients (TEC) in the heterostructures of GaN/SiC/porous Si/Si is conducted. It is revealed that the presence of pores in the near-surface layers of Si leads to considerable relaxation of elastic stresses in GaN films caused by differences in the TEC between GaN and Si

New Molecular Reporters for Rapid Protein Folding Assays

The GFP folding reporter assay [1] uses a C-terminal GFP fusion to report on the folding success of upstream fused polypeptides. The GFP folding assay is widely-used for screening protein variants with improved folding and solubility [2]–[8], but truncation artifacts may arise during evolution, i.e. from de novo internal ribosome entry sites [9]. One way to reduce such artifacts would be to insert target genes within the scaffolding of GFP circular permuted variants. Circular permutants of fluorescent proteins often misfold and are non-fluorescent, and do not readily tolerate fused polypeptides within the fluorescent protein scaffolding [10]–[12]. To overcome these limitations, and to increase the dynamic range for reporting on protein misfolding, we have created eight GFP insertion reporters with different sensitivities to protein misfolding using chimeras of two previously described GFP variants, the GFP folding reporter [1] and the robustly-folding “superfolder” GFP [13]. We applied this technology to engineer soluble variants of Rv0113, a protein from Mycobacterium tuberculosis initially expressed as inclusion bodies in Escherichia coli. Using GFP insertion reporters with increasing stringency for each cycle of mutagenesis and selection led to a variant that produced large amounts of soluble protein at 37°C in Escherichia coli. The new reporter constructs discriminate against truncation artifacts previously isolated during directed evolution of Rv0113 using the original C-terminal GFP folding reporter. Using GFP insertion reporters with variable stringency should prove useful for engineering protein variants with improved folding and solubility, while reducing the number of artifacts arising from internal cryptic ribosome initiation sites

Comparisons between Tethyan Anorthosite-bearing Ophiolites and Archean Anorthosite-bearing Layered Intrusions: Implications for Archean Geodynamic Processes

Elucidating the petrogenesis and geodynamic setting(s) of anorthosites in Archean layered intrusions and Tethyan ophiolites has significant implications for crustal evolution and growth throughout Earth history. Archean anorthosite-bearing layered intrusions occur on every continent. Tethyan ophiolites occur in Europe, Africa, and Asia. In this contribution, the field, petrographic, petrological, and geochemical characteristics of 100 Tethyan anorthosite-bearing ophiolites and 155 Archean anorthosite-bearing layered intrusions are compared. Tethyan anorthosite-bearing ophiolites range from Devonian to Paleocene in age, are variably composite, contain anorthosites with highly calcic (An44-100) plagioclase and magmatic amphibole. These ophiolites formed predominantly at convergent plate margins, with some forming in mid-ocean ridge, continental rift, and mantle plume settings. The predominantly convergent plate margin tectonic setting of Tethyan anorthosite-bearing ophiolites is indicated by negative Nb and Ti anomalies and magmatic amphibole. Archean anorthosite-bearing layered intrusions are Eoarchean to Neoarchean in age, have megacrystic anorthosites with highly calcic (An20-100) plagioclase and magmatic amphibole and are interlayered with gabbros and leucogabbros and intrude pillow basalts. These Archean layered intrusions are interpreted to have predominantly formed at convergent plate margins, with the remainder forming in mantle plume, continental rift, oceanic plateau, post-orogenic, anorogenic, mid-ocean ridge, and passive continental margin settings. These layered intrusions predominantly crystallized from hydrous Ca- and Al-rich tholeiitic magmas. The field, petrographic and geochemical similarities between Archean and Tethyan anorthosites indicate that they were produced by similar geodynamic processes mainly in suprasubduction zone settings. We suggest that Archean anorthosite-bearing layered intrusions and spatially associated greenstone belts represent dismembered subduction-related Archean ophiolites

HE-LHC: The High-Energy Large Hadron Collider – Future Circular Collider Conceptual Design Report Volume 4

In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries