691 research outputs found

    Citizenship rights for immigrants. National political processes and cross-national convergence in Western Europe, 1980–2008

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    Immigrant citizenship rights in the nation-state reference both theories of cross-national convergence and the resilience of national political processes. This article investigates European countries' attribution of rights to immigrants: Have these rights become more inclusive and more similar across countries? Are they affected by EU membership, the role of the judiciary, the party in power, the size of the immigrant electorate, or pressure exerted by anti-immigrant parties? Original data on 10 European countries, 1980-2008, reveal no evidence for cross-national convergence. Rights tended to become more inclusive until 2002, but stagnated afterward. Electoral changes drive these trends: growth of the immigrant electorate led to expansion, but countermobilization by right-wing parties slowed or reversed liberalizations. These electoral mechanisms are in turn shaped by long-standing policy traditions, leading to strong path dependence and the reproduction of preexisting cross-national differences. © 2012 by The University of Chicago. All rights reserved

    Impact assessment of agricultural research in West Africa: An application of the propensity score matching methodology

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    Ex-post evaluation of agricultural research is aimed to empirically provide evidence of past investments’ effectiveness. This paper is intended to measure the immediate impact of livestock research activities on cattle farmers’ knowledge about trypanosomosis and its curative and preventive control strategies. According to the quasi-experimental design of the intervention, it is shown that its impact will be adequately estimated by propensity score matching (PSM). Based on data collected according to a knowledge, attitude and practice (KAP) questionnaire in the region of Kénédougou that is common to Mali and Burkina Faso, results indicate a significant gain in farmers’ know-how due to participation in livestock research activities

    DaCToR: A data collection tool for the RELATER project

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    Collecting domain-specific data for under-resourced languages, e.g., dialects of languages, can be very expensive, potentially financially prohibitive and taking long time. Moreover, in the case of rarely written languages, the normalization of non-canonical transcription might be another time consuming but necessary task. In order to collect domain-specific data in such circumstances in a time and cost-efficient way, collecting read data of pre-prepared texts is often a viable option. In order to collect data in the domain of psychiatric diagnosis in Arabic dialects for the project RELATER, we have prepared the data collection tool DaCToR for collecting read texts by speakers in the respective countries and districts in which the dialects are spoken. In this paper we describe our tool, its purpose within the project RELATER and the dialects which we have started to collect with the tool

    Muang Rae Geothermal System: Drilling and Borehole Geophysics, 1000-m Core Hole into Granitic Rock, Amphoe Pai, Mae Hong Son Province, Northern Thailand

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    In 2015, a 1-km core hole was drilled into granitic rock at the Muang Rae geothermal area. Previous drilling in 1993 to 200 m was unsuccessful in obtaining flows, but one of the “dry” wells began flowing in August, 2013 at 9.75 L/s of 96.9°C water from a fracture zone 80 m deep. In the sandy bed of the Pai River, 150 m south of that well is a 600-m long line of hot seeps, oriented NE, with highest temperature measured at 94.5°C. Geology is foliated Triassic (?) granitic rock cut by a NE-SW-trending normal fault zone (dip 65° NW) with extensive fluorite mineralization. Mineral equilibrium geothermometer analysis predicts a reservoir temperature of 132°C. The core hole was sited NW of the seep zone to drill into the fault zone at 600 m. MT indicated a low-resistivity anomaly 150-500 m deep at the site. The well did not flow, but was pumped at 6.4 L/s of 86°C water with 2.5 m of drawdown. Temperature logs indicate the well intersects a fracture with flowing hot water of 91.5°C at 600 m. The log shows a temperature inversion related to the transient effect of conductive heating of the surrounding rock by hot-water flow in the fracture. The bottom 150 m of the well shows a 23°C/km temperature gradient, which reflects the regional crustal conductive gradient

    Assessing the impact of interfering organic matter on soil metaproteomic workflow

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    Funding: Matthias Waibel was funded by the University of Galway College of Science and the Irish Research Council under GOIPG/2016/1215. The James Hutton Institute receives funding support from the Rural and Environment Science and Analytical Services Division of the Scottish Government. Open access funding provided by IReL.Soil organic matter (SOM) is biologically, chemically, and physically complex. As a major store of nutrients within soil, it plays an important role in nutrient provision to plants. An enhanced understanding of SOM utilisation processes could underpin better fertiliser management for plant growth, with reduced environmental losses. Metaproteomics can allow the characterisation of protein profiles and could help gaining insights into SOM microbial decomposition mechanisms. Here, we applied three different extraction methods to two soil types to recover SOM with different characteristics. Specifically, water extractable organic matter, mineral associated organic matter and protein-bound organic matter were targeted with the aim to investigate the metaproteome enriched in those extractions. As a proof-of-concept replicated extracts from one soil were further analysed for peptide identification using liquid chromatography followed by tandem mass spectrometry. We employ a framework for mining mass spectra for both peptide assignment and fragmentation pattern characterisation. Different extracts were found to exhibit contrasting total protein and humic substance content for the two soils investigated. Overall, water extracts displayed the lowest humic substance content (in both soils) and the highest number of peptide identifications (in the soil investigated) with most frequent peptide hits associated with diverse substrate/ligand binding proteins of Proteobacteria and derived taxa. Our framework also highlighted a strong peptidic signal in unassigned and unmatched spectra, information that is currently not captured by the pipelines employed in this study. Taken together, this work points to specific areas for optimisation in chromatography and mass spectrometry to adequately characterise SOM associated metaproteomes.Publisher PDFPeer reviewe

    Chronic hypoxemia increases myocardial cytochrome oxidase

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    ObjectiveCyanotic patients have potentially decreased tissue oxygen tension. Cytochrome oxidase catalyzes the reduction of oxygen and is integral to adenosine triphosphate production. Cytochrome oxidase subunit I, the active site, is encoded by mitochondrial DNA. Using a newborn swine model of chronic hypoxemia, we evaluated ventricular cytochrome oxidase subunit I mRNA and protein expression and assessed cytochrome oxidase activity.MethodsThirty-two newborn piglets underwent thoracotomy and placement of a pulmonary artery–to–left atrium shunt or sham operation. Two weeks later, partial pressure of arterial oxygen, hematocrit, and left ventricular shortening fraction values were compared with baseline values. Northern blot hybridization and protein immunoblotting for ventricular cytochrome oxidase subunit I were performed. Cytochrome oxidase kinetic activity was measured. Heme a,a3 content and turnover number were determined. Significance was assessed with a t test.ResultsBaseline partial pressure of arterial oxygen and hematocrit values were similar. Hypoxemic piglets had a lower partial pressure of arterial oxygen of 38 ± 10 mm Hg (P < .001) and higher hematocrit value of 31.4% ± 2.9% (P < .001) compared with a partial pressure of arterial oxygen of 140 ± 47 mm Hg and hematocrit value of 24.6% ± 3.9% after the sham operation. Baseline and postprocedure left ventricular shortening fraction were similar within and between groups. Chronic hypoxemia increased right ventricular and left ventricular cytochrome oxidase I mRNA and protein by more than 1.4-fold. Cytochrome oxidase activity increased significantly in hypoxemia by 2.5-fold compared with that seen after the sham operation. Heme a,a3 content and turnover number increased by 1.5-fold during hypoxemia.ConclusionsChronic hypoxemia increases cytochrome oxidase I message, protein expression, and activity. The increase in kinetics was due to increased enzyme content and catalytic activity. This is a possible adaptive mechanism that might preserve organ function during chronic hypoxemia

    Short and oral antimicrobial therapy for diabetic foot infection: a narrative review of current knowledge

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    Diabetic foot infection is a frequent complication in long-standing diabetes mellitus. For antimicrobial therapy of this infection, both the optimal duration and the route of administration are often based more on expert opinion than on published evidence. We reviewed the scientific literature, specifically seeking prospective trials, and aimed at addressing two clinical issues: (1) shortening the currently recommended antibiotic duration and (2) using oral (rather than parenteral) therapy, especially after the patient has undergone debridement and revascularization. We also reviewed some older key articles that are critical to our understanding of the treatment of these infections, particularly with respect to diabetic foot osteomyelitis. Our conclusion is that the maximum duration of antibiotic therapy for osteomyelitis should be no more than to 4-6 weeks and might even be shorter in selected cases. In the future, in addition to conducting randomized trials and propagating national and international guidance, we should also explore innovative strategies, such as intraosseous antibiotic agents and bacteriophages

    INFRARED MEASUREMENTS AND ESTIMATION OF TEMPERATURE IN THE RESTRICTIVE SCOPE OF AN INDUSTRIAL CEMENT PLANT

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    In this paper, we describe and evaluate the process of estimating reflectance corrected temperatures based on infrared measurements in the scope of an industrial cement production plant. We overview the underlying cement production phases, as well as the resulting challenges for infrared-based monitoring in such an industrial environment. Our studies are focused particularly on the use of infrared sensors in the clinker cooling process. Using a highly specialized infrared camera (10.6&thinsp;&mu;m), a dataset is obtained capturing the radiation emissions of cement clinker during the clinker cooling process at a cement plant. We briefly turn on the necessity of image preprocessing and then focus on calculating reflectance corrected thermal images for temperature estimation without the use of reference markers or additional instrumentation. This study represents the first usage of infrared camera-based measurements in the clinker cooling process. The main contributions, a recorded dataset and two proposed estimation models including a linear model and a machine learning model with their respective temperature estimations, will provide the basis for the extraction of further process characteristics. Therefore, our contributions will enable scientists as well as process operators to gain new insights about the cement clinker cooling process and to optimize the cement cooling and production process automatically

    Robot life: simulation and participation in the study of evolution and social behavior.

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    This paper explores the case of using robots to simulate evolution, in particular the case of Hamilton's Law. The uses of robots raises several questions that this paper seeks to address. The first concerns the role of the robots in biological research: do they simulate something (life, evolution, sociality) or do they participate in something? The second question concerns the physicality of the robots: what difference does embodiment make to the role of the robot in these experiments. Thirdly, how do life, embodiment and social behavior relate in contemporary biology and why is it possible for robots to illuminate this relation? These questions are provoked by a strange similarity that has not been noted before: between the problem of simulation in philosophy of science, and Deleuze's reading of Plato on the relationship of ideas, copies and simulacra
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