Cultural Diversity and the Digital Humanities

Digital humanities has grown and changed over the years; we have moved away from expecting technology to be a tool to make humanities research easier and faster into one where we are now equal partners. Our collaborative projects drive forward the research agendas of both humanists and technologists. There have been other changes too. The focus of our scholarly interest has moved away from its historical origins in text-based scholarship, although that now has many more possibilities, and we are seeing an interest in exploring culture and heritage more widely. Where the progress is slower is in our moves towards openness and inclusivity, and this is to some extent hampered by a lack of linguistic diversity. This is being addressed with specialist groups within the major DH organizations on a national and a global level. DH has grown rapidly in China, and the anglophone world could do more to engage with practitioners and potential colleagues in this new vibrant and emerging area. There are certainly Western centres that specialize, particularly in Chinese texts and historical documents, but this needs to be extended further if we are not to impose limits on the conversations, synergies and collaborations that can result

Multicenter clinical evaluation of the Luminex Aries Flu A/B & RSV assay for pediatric and adult respiratory tract specimens

ABSTRACT Influenza A and B viruses and respiratory syncytial virus (RSV) are three common viruses implicated in seasonal respiratory tract infections and are a major cause of morbidity and mortality in adults and children worldwide. In recent years, an increasing number of commercial molecular tests have become available to diagnose respiratory viral infections. The Luminex Aries Flu A/B &amp; RSV assay is a fully automated sample-to-answer molecular diagnostic assay for the detection of influenza A, influenza B, and RSV. The clinical performance of the Aries Flu A/B &amp; RSV assay was prospectively evaluated in comparison to that of the Luminex xTAG respiratory viral panel (RVP) at four North American clinical institutions over a 2-year period. Of the 2,479 eligible nasopharyngeal swab specimens included in the prospective study, 2,371 gave concordant results between the assays. One hundred eight specimens generated results that were discordant with those from the xTAG RVP and were further analyzed by bidirectional sequencing. Final clinical sensitivity values of the Aries Flu A/B &amp; RSV assay were 98.1% for influenza A virus, 98.0% for influenza B virus, and 97.7% for RSV. Final clinical specificities for all three pathogens ranged from 98.6% to 99.8%. Due to the low prevalence of influenza B, an additional 40 banked influenza B-positive specimens were tested at the participating clinical laboratories and were all accurately detected by the Aries Flu A/B &amp; RSV assay. This study demonstrates that the Aries Flu A/B &amp; RSV assay is a suitable method for rapid and accurate identification of these causative pathogens in respiratory infections.</jats:p

Cultural institutions in the digital age: British Museum’s use of Facebook Insights

Over the last decade, museums have experienced a strong cultural shift from objectoriented towards audience-oriented strategic approaches. This paper reviews the relevant literature on this transition and provides supportive evidence of the impact that social media have upon the relationship between cultural organisations and their audiences. Data deriving from the use of the British Museum’s Facebook page provides a comprehensive evaluation of the museum’s general social media strategy. Given the dominance and widespread use of Facebook and other social media, the degree of engagement of cultural organisations with them, seem to have become an inseparable factor on the scale of effectiveness of the relation with their audiences and the levels of visitor attendance. This research aims, by using one of the most prestigious museums in Britain as a case study, to provide an initial comprehensive set of insights into the use of social media by cultural organisations. The findings of this study are based on research conducted for the first author’s postgraduate studies at the Centre for Digital Humanities, Department of Information studies, University College London

Science advice for global challenges: learning from trade-offs in the IPCC

In the context of ongoing debates about the place of knowledge and expertise in the governance of global challenges, this article seeks to promote cross-sectoral learning about the politics and pitfalls of global science advice. It begins with the intertwined histories of the Intergovernmental Panel on Climate Change (IPCC) and the global climate policy regime, before examining the politics of different ‘framings’ of the climate problem and the challenges of building and communicating scientific consensus. We then identify three important trade-offs which the IPCC has had to negotiate: global versus local; scientific disinterestedness versus policy-relevance; and consensus versus plurality. These lessons are especially timely as global institutions begin to convene knowledge to address urgent sustainable development challenges posed by anti-microbial resistance (AMR). While the IPCC experience does not provide a wholly transportable model for science advice, we show why similar trade-offs need to be addressed at an early stage by architects of advisory systems for AMR as well as other global challenges

A search for 21 cm HI absorption in AT20G compact radio galaxies

We present results from a search for 21 cm associated HI absorption in a sample of 29 radio sources selected from the Australia Telescope 20 GHz survey. Observations were conducted using the Australia Telescope Compact Array Broadband Backend, with which we can simultaneously look for 21 cm absorption in a redshift range of 0.04 < z < 0.08, with a velocity resolution of 7 km/s . In preparation for future large-scale H I absorption surveys we test a spectral-line finding method based on Bayesian inference. We use this to assign significance to our detections and to determine the best-fitting number of spectral-line components. We find that the automated spectral-line search is limited by residuals in the continuum, both from the band-pass calibration and spectral-ripple subtraction, at spectral-line widths of \Deltav_FWHM > 103 km/s . Using this technique we detect two new absorbers and a third, previously known, yielding a 10 per cent detection rate. Of the detections, the spectral-line profiles are consistent with the theory that we are seeing different orientations of the absorbing gas, in both the host galaxy and circumnuclear disc, with respect to our line-of-sight to the source. In order to spatially resolve the spectral-line components in the two new detections, and so verify this conclusion, we require further high-resolution 21 cm observations (~0.01 arcsec) using very long baseline interferometry.Comment: 16 pages, 8 figures and 5 tables; accepted for publication in MNRAS (version 2 based on proof corrections

The Structure of the [Zn_In - V_P] Defect Complex in Zn Doped InP

We study the structure, the formation and binding energies and the transfer levels of the zinc-phosphorus vacancy complex [Zn_In - V_P] in Zn doped p-type InP, as a function of the charge, using plane wave ab initio DFT-LDA calculations in a 64 atom supercell. We find a binding energy of 0.39 eV for the complex, which is neutral in p-type material, the 0/-1 transfer level lying 0.50 eV above the valence band edge, all in agreement with recent positron annihilation experiments. This indicates that, whilst the formation of phosphorus vacancies (V_P) may be involved in carrier compensation in heavily Zn doped material, the formation of Zn-vacancy complexes is not. Regarding the structure: for charge states Q=+6 to -4 the Zn atom is in an sp^2 bonded DX position and electrons added/removed go to/come from the remaining dangling bonds on the triangle of In atoms. This reduces the effective vacancy volume monatonically as electrons are added to the complex, also in agreement with experiment. The reduction occurs through a combination of increased In-In bonding and increased Zn-In electrostatic attraction. In addition, for certain charge states we find complex Jahn-Teller behaviour in which up to three different structures, (with the In triangle dimerised, antidimerised or symmetric) are stable and are close to degenerate. We are able to predict and successfully explain the structural behaviour of this complex using a simple tight binding model.Comment: 10 pages text (postscript) plus 8 figures (jpeg). Submitted to Phys. Rev.

Risk factors for bovine respiratory disease in Australian feedlot cattle: use of a causal diagram-informed approach to estimate effects of animal mixing and movements before feedlot entry

A nationwide longitudinal study was conducted to investigate risk factors for bovine respiratory disease (BRD) in cattle in Australian feedlots. After induction (processing), cattle were placed in feedlot pens (cohorts) and monitored for occurrence of BRD over the first 50 days on feed. Data from a national cattle movement database were used to derive variables describing mixing of animals with cattle from other farms, numbers of animals in groups before arrival at the feedlot, exposure of animals to saleyards before arrival at the feedlot, and the timing and duration of the animal's move to the vicinity of the feedlot. Total and direct effects for each risk factor were estimated using a causal diagram-informed process to determine covariates to include in four-level Bayesian logistic regression models. Mixing, group size and timing of the animal's move to the feedlot were important predictors of BRD. Animals not mixed with cattle from other farms prior to 12 days before induction and then exposed to a high level of mixing (≥4 groups of animals mixed) had the highest risk of developing BRD (OR 3.7) compared to animals mixed at least 4 weeks before induction with less than 4 groups forming the cohort. Animals in groups formed at least 13 days before induction comprising 100 or more (OR 0.5) or 50-99 (OR 0.8) were at reduced risk compared to those in groups of less than 50 cattle. Animals moved to the vicinity of the feedlot at least 27 days before induction were at reduced risk (OR 0.4) compared to cattle undergoing short-haul transportation

Concordance between decision analysis and matching systematic review of randomized controlled trials in assessment of treatment comparisons: a systematic review

BACKGROUND: Systematic review (SR) of randomized controlled trials (RCT) is the gold standard for informing treatment choice. Decision analyses (DA) also play an important role in informing health care decisions. It is unknown how often the results of DA and matching SR of RCTs are in concordance. We assessed whether the results of DA are in concordance with SR of RCTs matched on patient population, intervention, control, and outcomes. METHODS: We searched PubMed up to 2008 for DAs comparing at least two interventions followed by matching SRs of RCTs. Data were extracted on patient population, intervention, control, and outcomes from DAs and matching SRs of RCTs. Data extraction from DAs was done by one reviewer and from SR of RCTs by two independent reviewers. RESULTS: We identified 28 DAs representing 37 comparisons for which we found matching SR of RCTs. Results of the DAs and SRs of RCTs were in concordance in 73% (27/37) of cases. The sensitivity analyses conducted in either DA or SR of RCTs did not impact the concordance. Use of single (4/37) versus multiple data source (33/37) in design of DA model was statistically significantly associated with concordance between DA and SR of RCTs. CONCLUSIONS: Our findings illustrate the high concordance of current DA models compared with SR of RCTs. It is shown previously that there is 50% concordance between DA and matching single RCT. Our study showing the concordance of 73% between DA and matching SR of RCTs underlines the importance of totality of evidence (i.e. SR of RCTs) in the design of DA models and in general medical decision-making