Galactic cosmic ray antiprotons and supersymmetry

The physics of the annihilation of photinos is considered as a function of mass in detail, in order to obtain the energy spectra of the cosmic ray antiprotons produced under the assumption that photinos make up the missing mass in the galactic halo. The modulated spectrum is at 1 a.w. with the cosmic ray antiprotons data. A very intriguing fit is obtained to all of the present antiprotons up to 13.4 GeV data for similar to 15 GeV. A cutoff is predicted in the antiprotons spectrum at E = photino mass above which only a small flux from secondary production should remain

Evaluation of an in-capillary approach for performing quantitative cytochrome P450 activity studies

An automated in-capillary assay requiring very small quantities of reagents was developed for performing in vitro cytochrome P450 (CYP450) drug metabolism studies. The approach is based on the following: (i) hydrodynamic introduction of nanoliter volumes of substrate and enzyme solutions in the sandwich mode, within a capillary; (ii) mixing the reagents by diffusion across the interfaces between the injected solutions; (iii) collection of the capillary content at the end of the in-capillary assay; and (iv) off-line analysis of the incubation mixture by ultrahigh pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). After optimizing the injection sequence of the reagents, the in-capillary approach was applied to the quantitative determination of the kinetics of drug metabolism reactions catalyzed by three CYP450 isozymes involved in human drug metabolism: CYP1A2, CYP2D6, and CYP3A4. It was demonstrated that this in-capillary method was able to provide similar kinetic parameters for CYP450 activity (e.g., Michaelis constants and turnover values) as the classical in vitro method, with a drastic reduction of reagent consumption. Injection setups used for in-capillary CYP450 assay

Chiral Anomaly and γ3π\gamma 3\pi

Measurement of the $\gamma 3\pi$ process has revealed a possible conflict with what should be a solid prediction generated by the chiral anomaly. We show that inclusion of appropirate energy-momentum dependence in the matrix element reduces the discrepancy.Comment: 8 page standard Latex fil

Single Leptoquark Production at Hadron Colliders

Leptoquarks can be produced in pairs by gluon--gluon fusion and quark--antiquark annihilation at hadron colliders. While HERA is the proper machine for single production of $(eu)$ and $(ed)$ type leptoquarks, the flavor species of ($\mu u$), ($\mu d$) and ($\tau u$), ($\tau d$) type leptoquarks can be produced at hadron colliders very efficiently. Besides exploiting gluon-quark collisions, leptoquarks can also be produced singly by colliding the quarks in one proton beam with leptons $e,\mu,\tau$ generated by splitting photons which are radiated off the quarks in the other proton beam. For Yukawa couplings of the size $\alpha$ leptoquark masses up to about 300~GeV can be generated at the Tevatron while the LHC can produce leptoquarks with masses up to about 3~TeV. [Leptoquarks involving heavy quarks can be produced singly at a lower rate, determined by the heavy flavor flux in the proton beam.]Comment: 7 LaTex pages plus 2 uuencoded postscript files appended, DESY 94--086, UCD--94--17, UMN--TH--1258/94. Latex and postscipt files are also available via anonymous ftp at ucdhep.ucdavis.edu in directory [anonymous.ohnemus.ucd-94-17

Partial Derivation of Transformation Properties of Quarks and Leptons

Under the assumptions that $SU(3)_c\times U(1)_Y \times G^{\prime}$ with $G^{\prime}$ simple is a local symmetry group at high energies, that color is parity-conserving, and the Y-charges are irreducible, we show that anomaly constraints imply the minimal set of fermions is fifteen in number. Given this minimal set, we further show that $G^{\prime}$ must be $SU(2)$ and the unbroken gauge symmetry is {\it either} color {\it or} the product of color with electric charge.Comment: 9 pages, UMDHEP 94-72 and IFP-487-UN

Psychological Distress and Well-Being among Students of Health Disciplines: The Importance of Academic Satisfaction

Background: Research on the mental health of students in health disciplines mainly focuses on psychological distress and nursing and medical students. This study aimed to investigate the psychological well-being and distress and related factors among undergraduate students training in eight different health-related tracks in Geneva, Switzerland. Methods: This cross-sectional study used established self-filled scales for anxiety, depression, stress, psychological well-being, and study satisfaction. Descriptive statistics and hierarchical regression analyses were applied. Results: In October 2019, out of 2835 invited students, 915 (32%) completed the survey. Lower academic satisfaction scores were strongly associated with depression (β = −0.26, p < 0.001), anxiety (β = −0.27, p < 0.001), and stress (β = −0.70, p < 0.001), while higher scores were associated with psychological well-being (β = 0.70, p < 0.001). Being female was strongly associated with anxiety and stress but not with depression or psychological well-being. Increased age was associated with enhanced psychological well-being. The nature of the academic training had a lesser impact on mental health and the academic year had none. Conclusion: Academic satisfaction strongly predicts depression, anxiety, stress, and psychological well-being. Training institutions should address the underlying factors that can improve students’ satisfaction with their studies while ensuring that they have access to psychosocial services that help them cope with mental distress and enhance their psychological well-bein

A novel ultra-high-performance supercritical fluid chromatography hyphenated to tandem mass spectrometry method for the analysis of urinary endogenous steroids in the anti-doping context.

The first step in the detection of testosterone (T) doping is to measure the urinary steroid profile for the athlete biological passport (ABP). To harmonise the analysis between anti-doping laboratories, urinary steroid profiling is parametrised in deep detail and shall be performed by gas chromatography hyphenated to mass spectrometry (GC-MS). However, due to its requirement for extensive sample preparation, alternatives to GC-MS are being actively pursued. The aim of this study was the evaluation of Ultra-High-Performance Supercritical Fluid Chromatography hyphenated to tandem Mass Spectrometry (UHPSFC-MS/MS) as an alternative for the quantification of endogenous urinary steroids. In this context, we developed a high throughput sample extraction method, followed by a novel UHPSFC-MS/MS method for the analysis of 10 endogenous urinary steroids which are relevant for doping control analysis. Depending on the steroid, the herein presented method is capable of quantification from 0.5 ng/mL up to 10 µg/mL. After validation, the applicability of the method was evaluated by analysing 132 authentic urine samples, which demonstrated results similar to classical GC-MS analysis. Steroid concentrations determined by UHPSFC-MS/MS were slightly overestimated in comparison with GC-MS, but the ratios had &lt;10 % difference between the two methods. As the ABP considers the steroid ratios for passport evaluation, the herein presented method could be used for steroid profiling without reducing the sensitivity of the ABP. Thus, we would propose to consider UHPSFC-MS/MS as an alternative to GC-MS after more tests would have been performed to support our findings. Furthermore, we have also investigated the potential of this technology for sample purification prior to Isotope Ratio Mass Spectrometry (IRMS) for the differentiation between exogenous and endogenous origin of T and its metabolites. While the achieved separation was sufficient to purify urine samples for IRMS analysis in our proof-of-concept study, the instrumental parameters should be further refined for future use

How does the geodesic rule really work for global symmetry breaking first order phase transitions?

The chain of events usually understood to lead to the formation of topological defects during phase transitions is known as the Kibble mechanism. A central component of the mechanism is the so-called ``geodesic rule''. Although in the Abelian Higgs model the validity of the geodesic rule has been questioned recently, it is known to be valid on energetic grounds for a global U(1) symmetry breaking transition. However, even for these globally symmetric models no dynamical analisys of the rule has been carried to this date, and some points as to how events proceed still remain obscure. This paper tries to clarify the dynamics of the geodesic rule in the context of a global U(1) model. With an appropriate ansatz for the field modulus we find a family of analytical expressions, phase walls, that accounts for both geodesic and nongeodesic configurations. We then show how the latter ones are unstable and decay into the former by nucleating pairs of defects. Finnally, we try to give a physical perspective of how the geodesic rule might really work in these transitions.Comment: 10 pages, 9 multiple figre

Positrons from particle dark-matter annihilation in the Galactic halo: propagation Green's functions

We have made a calculation of the propagation of positrons from dark-matter particle annihilation in the Galactic halo in different models of the dark matter halo distribution using our 3D code, and present fits to our numerical propagation Green's functions. We show that the Green's functions are not very sensitive to the dark matter distribution for the same local dark matter energy density. We compare our predictions with computed cosmic ray positron spectra (``background'') for the ``conventional'' CR nucleon spectrum which matches the local measurements, and a modified spectrum which respects the limits imposed by measurements of diffuse Galactic gamma-rays, antiprotons, and positrons. We conclude that significant detection of a dark matter signal requires favourable conditions and precise measurements unless the dark matter is clumpy which would produce a stronger signal. Although our conclusion qualitatively agrees with that of previous authors, it is based on a more realistic model of particle propagation and thus reduces the scope for future speculations. Reliable background evaluation requires new accurate positron measurements and further developments in modelling production and propagation of cosmic ray species in the Galaxy.Comment: 8 pages, 6 ps-figures, 3 tables, uses revtex. Accepted for publication in Physical Review D. More details can be found at http://www.gamma.mpe-garching.mpg.de/~aws/aws.htm