DIGITAL EDUCATIONAL ENVIRONMENT AS A TOOL OF SYSTEM CHANGES IN THE TEACHER’S PROFESSIONAL ACTIVITY

Purpose: Social and cultural prerequisites of Russia’s transition to an open information society have predetermined new requirements for graduates of modern educational organizations, ready for communicative activities in a digital educational environment. Informatization of education is characterized by increasing virtualization of the educational process and, as a consequence, the predominance of fragmented thinking, and increase in the gap between traditional and innovative educational technologies. Methodology: The basis of the digital educational environment in the context of the use of knowledge management technologies can be specialized knowledge management systems that combine knowledge of related scientific disciplines, which should provide integration, accumulation, and support, as well as the organization of access to knowledge of the educational environment. A distinctive feature of the development of mankind at the present stage is the transition to information society in which information and information processes are becoming one of the most important components of human life and society. Result: The development of the global process of informatization of society leads to the formation of not only the new information environment for people but also new, information way of their life and professional activities. Many researchers as the most acute problem of modern education called the mismatch of software, including for educational purposes, to high technical characteristics of computers, resulting in extremely low efficiency of computer use in training. Critically assessing the effectiveness of the existing software of the educational process and the ways of its development, we see the prospects for a radical change in the situation in the orientation to the use of knowledge management technologies that use software products that can be changed, adapting to the needs of the user and, in particular, to the didactic tasks of training. Applications: This research can be used for universities, teachers, and students. Novelty/Originality: In this research, the model of Digital Educational Environment as a Tool of System Changes in the Teacher’s Professional Activity is presented in a comprehensive and complete manner

Structural/Functional Modifications in the Mitochondria of Brainstem Cells in Rat Offspring Subjected to Prenatal Hypoxia

We examined changes in the morphofunctional state of the mitochondria (MCh) and immunohistochemical peculiarities of brainstem neurons in rat offspring exposed to experimental prenatal (intrauterine) hypoxia of different severity, moderate and strong. This was provided by exposure of pregnant females to O2/N2 respiratory mixtures containing 12 and 7% O2, respectively. Experimental groups included 20 one-month-old rats (offspring of 9 females, control and subjected to hypoxia). We estimated the ultrastructural characteristics of the MCh and also expression of the CD95 APO-1/Fas and Bcl-2 genes modulating the intensity of apoptosis and mitoptosis in these cells. Severe intrauterine hypoxia resulted in the development of structural distress in the MCh of brainstem cells; all stages of MCh degradation, from swelling to complete dissipation, were observed. Juvenile forms of these organelles were absent. Mosaic-like destruction of myelin with manifestations of edema was observed. After the moderate prenatal hypoxia, about half of the changes in the MCh ultrastructure could be qualified as directed toward an increase in the compensatory capabilities of the MCh apparatus. In rats after moderate hypoxic influence, levels of expression of the CD95 APO-1/Fas and Bcl-2 genes were indicative of a greater readiness of the neurons to apoptosis and decrease in the probability to inhibition of the respective MCh pathway in brainstem neurocites. At the same time, the MCh and neurocites of animals subjected to severe intrauterine hypoxia demonstrated decreased trends toward mitoptosis and apoptosis, respectively. The obtained results characterizing the effects of intrauterine hypoxia of different levels on the formation of structural/functional changes in the MCh of brainstem cells can be taken into account in the process of development of novel approaches to the treatment of MCh diseases

Age changes of blood microcirculation in students and sportsmen under the influence of physical training

Age specifi c features of blood microcircula詛 on reac誛 vity in students and athletes (freestyle wrestling at the level of candidates for a master of sports) are studied for 18 to 21 years under the infl uence of a dosed physical training. Signifi cant diff erences in the values of the most parameters characterizing the microcircula萋 on of blood at rest were observed between the 4 age groups under examina裻 on, both in students and athletes with diff erent levels of the microcircula萋 on index, and it was shown that the contribu詻 on of ac詻 ve modula脫 ons of the blood fl ow to the forma裻 on of its profi le is more important. Regular exercise changes the age dependence of the level of muscle 詻 ssue perfusion, as well as the amplitude of blood fl ow fl uctua詻 ons in 裻 ssues. Essen裻 al diff erences in the eff ect of physical training on the eff ec譋 veness of microcircula譋 on in stu- dents and athletes have been established, depending on the value of the microcircula誛 on index. The results indicate the need to take into account the hierarchy of regulatory mechanisms in the selec荫 on of the intensity of physical training, as well as the possibility of a targeted eff ect on respiratory-pulse modula講 on in the microvasculature and, consequently, on their ra譛 o, by means of dosed physical training

Search for sterile neutrinos at the DANSS experiment

DANSS is a highly segmented 1~m${}^3$ plastic scintillator detector. Its 2500 one meter long scintillator strips have a Gd-loaded reflective cover. The DANSS detector is placed under an industrial 3.1~$\mathrm{GW_{th}}$ reactor of the Kalinin Nuclear Power Plant 350~km NW from Moscow. The distance to the core is varied on-line from 10.7~m to 12.7~m. The reactor building provides about 50~m water-equivalent shielding against the cosmic background. DANSS detects almost 5000 $\widetilde\nu_e$ per day at the closest position with the cosmic background less than 3$\%$. The inverse beta decay process is used to detect $\widetilde\nu_e$. Sterile neutrinos are searched for assuming the $4\nu$ model (3 active and 1 sterile $\nu$). The exclusion area in the $\Delta m_{14}^2,\sin^22\theta_{14}$ plane is obtained using a ratio of positron energy spectra collected at different distances. Therefore results do not depend on the shape and normalization of the reactor $\widetilde\nu_e$ spectrum, as well as on the detector efficiency. Results are based on 966 thousand antineutrino events collected at 3 distances from the reactor core. The excluded area covers a wide range of the sterile neutrino parameters up to $\sin^22\theta_{14}<0.01$ in the most sensitive region.Comment: 10 pages, 13 figures, version accepted for publicatio

Yield performance and stability of modern breeding stock of spring durum wheat (Triticum durum Desf.) from Russia and Kazakhstan

Identifcation of adaptive responses of breeding material, developed in different breeding centers, helps to purposefully correct these traits where it is necessary. Thus, 42 modern breeding lines from eight institutions of Russia and Kazakhstan were studied in comparison with the historical standard Bezenchukskaya 139 in trails of 16-17 and 18 KASIB-SDW (Kazakhstan-Siberian net for wheat improvement, spring durum wheat) in 2015–2017. Field experiments and yield measurements in each ecological cite were similar. To solve these tasks of the experiment, two-factor ANOVA, methods for adaptability assessment cluster analysis and principle component method were applied. As a result, it was established that 1) genotype and genotype – environment interaction (overall 15.8–23.5 % of total dispersion) had signifcant effect on yield variability; 2) genotype – environment interactions were of linear nature and had no destabilizing effect; 3) all the genotypes tested can be distributed in three clusters, the frst one for locally adapted varieties, the third for varieties of a wide areal, the second included genotypes with intermediate characteristics; 4) breeding centers of the Federal Altai Scientifc Centre of Agro-Biotechnologies and of the Research Institute of Agriculture of South-East produced predominantly varieties of local importance, the Samara Research Institute of Agriculture – varieties of wide area; 5) a stable trend of increased mean yield compared to historical standard Bezenchukskaya 139 over ecological sites was observed only for Samara varieties; 6) varieties of all the breeding centers had no stable difference from Bezenchukskaya 139 concerning stability and responsiveness, which can be explained by an incomplete breeding process for these parameters and confrms the importance of the KASIB program; 7) a trend of yield increase compared to Bezenchukskaya 139 under testing in defnite local environments had more stable parameters with the largest progress observed in the Altai Research Institute of Agriculture (135.4 and 163.2 % to Bezenchukskaya 139), which can be explained by a high efciency of breeding of locally adapted varieties in the breeding center

Draft genomes of gammaproteobacterial methanotrophs isolated from terrestrial ecosystems

Genome sequences of Methylobacter luteus, Methylobacter whittenburyi, Methylosarcina fibrata, Methylomicrobium agile, and Methylovulum miyakonense were generated. The strains represent aerobic methanotrophs typically isolated from various terrestrial ecosystems

First demonstration of 30 eVee ionization energy resolution with Ricochet germanium cryogenic bolometers

The future Ricochet experiment aims to search for new physics in the electroweak sector by measuring the Coherent Elastic Neutrino-Nucleus Scattering process from reactor antineutrinos with high precision down to the sub-100 eV nuclear recoil energy range. While the Ricochet collaboration is currently building the experimental setup at the reactor site, it is also finalizing the cryogenic detector arrays that will be integrated into the cryostat at the Institut Laue Langevin in early 2024. In this paper, we report on recent progress from the Ge cryogenic detector technology, called the CryoCube. More specifically, we present the first demonstration of a 30~eVee (electron equivalent) baseline ionization resolution (RMS) achieved with an early design of the detector assembly and its dedicated High Electron Mobility Transistor (HEMT) based front-end electronics. This represents an order of magnitude improvement over the best ionization resolutions obtained on similar heat-and-ionization germanium cryogenic detectors from the EDELWEISS and SuperCDMS dark matter experiments, and a factor of three improvement compared to the first fully-cryogenic HEMT-based preamplifier coupled to a CDMS-II germanium detector. Additionally, we discuss the implications of these results in the context of the future Ricochet experiment and its expected background mitigation performance.Comment: 10 pages, 5 figures, 1 tabl

Coherent elastic neutrino-nucleus scattering: Terrestrial and astrophysical applications

Coherent elastic neutrino-nucleus scattering (CE$\nu$NS) is a process in which neutrinos scatter on a nucleus which acts as a single particle. Though the total cross section is large by neutrino standards, CE$\nu$NS has long proven difficult to detect, since the deposited energy into the nucleus is $\sim$ keV. In 2017, the COHERENT collaboration announced the detection of CE$\nu$NS using a stopped-pion source with CsI detectors, followed up the detection of CE$\nu$NS using an Ar target. The detection of CE$\nu$NS has spawned a flurry of activities in high-energy physics, inspiring new constraints on beyond the Standard Model (BSM) physics, and new experimental methods. The CE$\nu$NS process has important implications for not only high-energy physics, but also astrophysics, nuclear physics, and beyond. This whitepaper discusses the scientific importance of CE$\nu$NS, highlighting how present experiments such as COHERENT are informing theory, and also how future experiments will provide a wealth of information across the aforementioned fields of physics

Coherent elastic neutrino-nucleus scattering: Terrestrial and astrophysical applications

Coherent elastic neutrino-nucleus scattering (CE$\nu$NS) is a process inwhich neutrinos scatter on a nucleus which acts as a single particle. Thoughthe total cross section is large by neutrino standards, CE$\nu$NS has longproven difficult to detect, since the deposited energy into the nucleus is$\sim$ keV. In 2017, the COHERENT collaboration announced the detection ofCE$\nu$NS using a stopped-pion source with CsI detectors, followed up thedetection of CE$\nu$NS using an Ar target. The detection of CE$\nu$NS hasspawned a flurry of activities in high-energy physics, inspiring newconstraints on beyond the Standard Model (BSM) physics, and new experimentalmethods. The CE$\nu$NS process has important implications for not onlyhigh-energy physics, but also astrophysics, nuclear physics, and beyond. Thiswhitepaper discusses the scientific importance of CE$\nu$NS, highlighting howpresent experiments such as COHERENT are informing theory, and also how futureexperiments will provide a wealth of information across the aforementionedfields of physics.<br