893 research outputs found
An Analysis of the Broadband (22-3900 MHz) Radio Spectrum of HB3 (G132.7+1.3): The Detection of Thermal Radio Emission from an Evolved Supernova Remnant?
We present an analysis of the broadband radio spectrum (from 22 to 3900 MHz)
of the Galactic supernova remnant (SNR) HB3 (G132.7+1.3). Published
observations have revealed that a curvature is present in the radio spectrum of
this SNR, indicating that a single synchrotron component appears is
insufficient to adequately fit the spectrum. We present here a fit to this
spectrum using a combination of a synchrotron component and a thermal
bremsstrahlung component. We discuss properties of this latter component and
estimate the ambient density implied by the presence of this component to be n
\~ 10 cm^-3. We have also analyzed extracted X-ray spectra from archived {\it
ASCA} GIS observations of different regions of HB3 to obtain independent
estimates of the density of the surrounding interstellar medium (ISM). From
this analysis, we have derived electron densities of 0.1-0.4 f^-1/2 cm^-3 for
the ISM for the three different regions of the SNR, where f is the volume
filling factor. By comparing these density estimates with the estimate derived
from the thermal bremsstrahlung component, we argue that the radio thermal
bremsstrahlung emission is emitted from a thin shell enclosing HB3. The
presence of this thermal bremsstrahlung component in the radio spectrum of HB3
suggests that this SNR is in fact interacting with an adjacent molecular cloud
associated with the HII region W3. By extension, we argue that the presence of
thermal emission at radio wavelengths may be a useful tool for identifying
interactions between SNRs and molecular clouds, and for estimating the ambient
density near SNRs using radio continuum data.Comment: 5 pages, 2 figures, accepted for ApJ
Epistasis between 5-HTTLPR and ADRA2B polymorphisms influences attentional bias for emotional information in healthy volunteers
Individual differences in emotional processing are likely to contribute to vulnerability and resilience to emotional disorders such as depression and anxiety. Genetic variation is known to contribute to these differences but they remain incompletely understood. The serotonin transporter (5-HTTLPR) and alpha(2B)-adrenergic autoreceptor (ADRA2B) insertion/deletion polymorphisms impact on two separate but interacting monaminergic signalling mechanisms that have been implicated in both emotional processing and emotional disorders. Recent studies suggest that the 5-HTTLPR s allele is associated with a negative attentional bias and an increased risk of emotional disorders. However, such complex behavioural traits are likely to exhibit polygenicity, including epistasis. This study examined the contribution of the 5-HTTLPR and ADRA2B insertion/deletion polymorphisms to attentional biases for aversive information in 94 healthy male volunteers and found evidence of a significant epistatic effect (p < 0.001). Specifically, in the presence of the 5-HTTLPR s allele, the attentional bias for aversive information was attenuated by possession of the ADRA2B deletion variant whereas in the absence of the s allele, the bias was enhanced. These data identify a cognitive mechanism linking genotype-dependent serotonergic and noradrenergic signalling that is likely to have implications for the development of cognitive markers for depression/anxiety as well as therapeutic drug effects and personalized approaches to treatment
The star-forming content of the W3 giant molecular cloud
We have surveyed a ~0.9-square-degree area of the W3 giant molecular cloud
and star-forming region in the 850-micron continuum, using the SCUBA bolometer
array on the James Clerk Maxwell Telescope. A complete sample of 316 dense
clumps was detected with a mass range from around 13 to 2500 Msun. Part of the
W3 GMC is subject to an interaction with the HII region and fast stellar winds
generated by the nearby W4 OB association. We find that the fraction of total
gas mass in dense, 850-micron traced structures is significantly altered by
this interaction, being around 5% to 13% in the undisturbed cloud but ~25 - 37%
in the feedback-affected region. The mass distribution in the detected clump
sample depends somewhat on assumptions of dust temperature and is not a simple,
single power law but contains significant structure at intermediate masses.
This structure is likely to be due to crowding of sources near or below the
spatial resolution of the observations. There is little evidence of any
difference between the index of the high-mass end of the clump mass function in
the compressed region and in the unaffected cloud. The consequences of these
results are discussed in terms of current models of triggered star formation.Comment: 13 pages, 8 figures, 1 table (full source table available on
request). Accepted for publication in Monthly Notices of the Royal
Astronomical Society (Main Journal
Radio polarimetric imaging of the interstellar medium: magnetic field and diffuse ionized gas structure near the W3/W4/W5/HB3 complex
We have used polarimetric imaging to study the magneto-ionic medium of the
Galaxy, obtaining 1420 MHz images with an angular resolution of 1' over more
than 40 square-degrees of sky around the W3/W4/W5/HB3 HII region/SNR complex in
the Perseus Arm. Features detected in polarization angle are imposed on the
linearly polarized Galactic synchrotron background emission by Faraday rotation
arising in foreground ionized gas having an emission measure as low as 1
cm^{-6} pc. Several new remarkable phenomena have been identified, including:
mottled polarization arising from random fluctuations in a magneto-ionic screen
that we identify with a medium in the Perseus Arm, probably in the vicinity of
the HII regions themselves; depolarization arising from very high rotation
measures (several times 10^3 rad m^{-2}) and rotation measure gradients due to
the dense, turbulent environs of the HII regions; highly ordered features
spanning up to several degrees; and an extended influence of the HII regions
beyond the boundaries defined by earlier observations. In particular, the
effects of an extended, low-density ionized halo around the HII region W4 are
evident, probably an example of the extended HII envelopes postulated as the
origin of weak recombination-line emission detected from the Galactic ridge.
Our polarization observations can be understood if the uniform magnetic field
component in this envelope scales with the square-root of electron density and
is 20 microG at the edge of the depolarized region around W4, although this is
probably an over-estimate since the random field component will have a
significant effect.Comment: 18 pages, 8 figures (7 jpeg and 1 postscript), accepted for
publication in the Astrophysical Journa
G55.0+0.3: A Highly Evolved Supernova Remnant
Multi-frequency analysis has revealed the presence of a new supernova
remnant, G55.0+0.3, in the Galactic plane. A kinematic distance of 14 kpc has
been measured from HI spectral line data. The faint, clumpy half-shell is
non-thermal and has a physical radius of 70 pc. Using an evolutionary model,
the age of the remnant is estimated to be on the order of one million years,
which exceeds conventional limits by a factor of five. The remnant may be
associated with the nearby pulsar J1932+2020, which has a spin-down age of 1.1
million years. This work implies that the radiative lifetimes of remnants could
be much longer than previously suggested.Comment: 27 pages, 7 figures in 9 files (figures 1 and 2 require 2 files
each), Accepted for publication in The Astrophysical Journal (Jan. 20, 1998
volume
Determination of multi-mycotoxin occurrence in maize based porridges from selected regions of Tanzania by liquid chromatography tandem mass spectrometry (LC-MS/MS), a longitudinal study
Enhanced abundances in three large-diameter mixed-morphology supernova remnants
We present an X-ray study of three mixed-morphology supernova remnants
(SNRs), HB 21, CTB 1 and HB 3, using archival ASCA and ROSAT data. These data
are complemented by archival Chandra X-ray Observatory data for CTB 1 and
XMM-Newton X-ray Observatory data for HB 3. The spectra from HB 21 and HB 3 are
well-described with a single-temperature thermal plasma in ionization
equilibrium, while a two-temperature thermal plasma is found in CTB 1. We found
enhanced abundances in all three SNRs. The elemental abundance of Mg is clearly
enhanced in CTB 1, while HB 21 has enhanced abundances of Si and S. The
situation is not so clear in HB 3 -- the plasma in this SNR either has
significantly enhanced abundances of O, Ne and Mg, or it has marginally
enhanced abundances of Mg and under-abundant Fe. We discuss the plausibility of
mixed-morphology SNR models for the three SNRs and the presence of enhanced
abundances. We revise a list of MM SNRs and their properties, compare the three
SNRs studied here with other members of this class, and discuss the presence of
enhanced elemental abundances in MM SNRs. We also report the ASCA detection of
a compact source in the southern part of HB 3. The source spectrum is
consistent with a power law with a photon index of ~2.7, and an unabsorbed
X-ray flux of ~10^{-12} erg/cm^2/s in the 0.5--10.0 keV band. The column
density towards this source differs from that towards the SNR, and it is
therefore unlikely they are related.Comment: 26 pages, 15 figures, revised version (minor changes), accepted for
publication in ApJ (10 Aug 2006
Fate of conjugated natural and synthetic steroid estrogens in crude sewage and activated sludge batch studies
This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Environmental Science & Technology, copyright © American Chemical Society after peer review. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/es801952h.Steroids are excreted from the human body in the conjugated form but are present in sewage influent and effluent as the free steroid, the major source of estrogenic activity observed in water courses. The fate of sulfate and glucuronide conjugated steroid estrogens was investigated in batch studies using activated sludge grown on synthetic sewage in a laboratory-scale Husmann simulation and crude sewage from the field. A clear distinction between the fate of sulfate and glucuronide conjugates was observed in both matrices, with sulfated conjugates proving more recalcitrant and glucuronide deconjugation preferential in crude sewage. For each conjugate, the free steroid was observed in the biotic samples. The degree of free steroid formation was dependent on the conjugate moiety, favoring the glucuronide. Subsequent degradation of the free steroid (and sorption to the activated sludge solid phase) was evaluated. Deconjugation followed the first order reaction rate with rate constants for 17α-ethinylestradiol 3-glucuronide, estriol 16α-glucuronide, and estrone 3-glucuronide determined as 0.32, 0.24, and 0.35 h respectively. The activated sludge solid retention time over the range of 3−9 days had 74 to 94% of sulfate conjugates remaining after 8 h. In contrast, a correlation between increasing temperature and decreasing 17α-ethinylestradiol 3-glucuronide concentrations in the activated sludge observed no conjugate present in the AS following 8 h at 22 °C Based on these batch studies and literature excretion profiles, a hypothesis is presented on which steroids and what form (glucuronide, sulfate, or free) will likely enter the sewage treatment plant.EPSR
GPCR-styrene maleic acid lipid particles (GPCR-SMALPs):their nature and potential
G-protein-coupled receptors (GPCRs) form the largest class of membrane proteins and are an important target for therapeutic drugs. These receptors are highly dynamic proteins sampling a range of conformational states in order to fulfil their complex signalling roles. In order to fully understand GPCR signalling mechanisms it is necessary to extract the receptor protein out of the plasma membrane. Historically this has universally required detergents which inadvertently strip away the annulus of lipid in close association with the receptor and disrupt lateral pressure exerted by the bilayer. Detergent-solubilized GPCRs are very unstable which presents a serious hurdle to characterization by biophysical methods. A range of strategies have been developed to ameliorate the detrimental effect of removing the receptor from the membrane including amphipols and reconstitution into nanodics stabilized by membrane scaffolding proteins (MSPs) but they all require exposure to detergent. Poly(styrene-co-maleic acid) (SMA) incorporates into membranes and spontaneously forms nanoscale poly(styrene-co-maleic acid) lipid particles (SMALPs), effectively acting like a 'molecular pastry cutter' to 'solubilize' GPCRs in the complete absence of detergent at any stage and with preservation of the native annular lipid throughout the process. GPCR-SMALPs have similar pharmacological properties to membrane-bound receptor, exhibit enhanced stability compared with detergent-solubilized receptors and being non-proteinaceous in nature, are fully compatible with downstream biophysical analysis of the encapsulated GPCR
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