Struggling to Compete: Community-Based Research on Agrarian Change in the Caribbean

Many countries in the Global South have agricultural landscapes and economies that are heavily dependent upon a small range of agro-exports, such as bananas. Tropical agro-exports have long earned low prices in international markets, which led to a number of historical policy responses geared towards stabilizing export prices and volumes. However, since the 1990s these have been overwhelmed by trade liberalization, intensifying pressures to lower costs of production and exacerbating the enduring challenges associated with tropical agro-export commodity dependence. This research seeks to understand these contemporary challenges through immersed fieldwork in rural communities. Through interviews with small farmers, farm workers, managers, owners, and government and corporate officials (n=200), it explores and compares different responses to the demise of preferential market access for bananas in two countries where dependence rests on very different productive systems: Dominica, where small farmers predominate, and Belize, where plantations prevail. In Dominica, banana production has drastically declined in the wake of trade liberalization, and most small farmers have entered a Fairtrade market with limited success. In marked contrast, banana production in Belize has continued rising, in large measure because plantations have entered a high-value niche market. However, this export growth depends upon a steady labour force which plantations are struggling to reproduce, a dynamic that is threatening to undermine the basis of this new niche. These divergent case studies problematize the impacts of trade liberalization in agriculture, and question the merits of agrarian development focused on commodity exports into the future. While this dissertation was inspired by a concern about the imbalances of the global food economy, another significant trajectory emerged through data collection: the gendered nature – and risks – of immersed fieldwork, and the void in the literature on issues of sexual violence in the field. Both conceptions and practices in feminist methodologies about reducing distance and balancing power in the field need to take into account the gendered risks of sexual violence. Conversations about sexual violence in fieldwork are needed to better prepare researchers, and are central to challenging entrenched perceptions of what is ‘rigorous’ research and the latent male archetype of the ‘ideal’ researcher

Dose-dependent effects of a soluble dietary fibre (pectin) on food intake, adiposity, gut hypertrophy and gut satiety hormone secretion in rats

Acknowledgments We thank Donna Wallace and Animal House staff at the Rowett Institute of Nutrition and Health for the daily care of experimental rats and for the body weight, food intake and MRI measurements.Peer reviewedPublisher PD

HST STIS Ultraviolet Spectral Evidence of Outflow in Extreme Narrow-line Seyfert 1 Galaxies: II. Modeling and Interpretation

We present modeling to explore the conditions of the broad-line emitting gas in two extreme Narrow-line Seyfert 1 galaxies, using the observational results described in the first paper of this series. Photoionization modeling using Cloudy was conducted for the broad, blueshifted wind lines and the narrow, symmetric, rest-wavelength-centered disk lines separately. A broad range of physical conditions were explored for the wind component, and a figure of merit was used to quantitatively evaluate the simulation results. Of the three minima in the figure-of-merit parameter space, we favor the solution characterized by an X-ray weak continuum, elevated abundances, a small column density (log(N_H)\approx 21.4), relatively high ionization parameter (log(U)\approx -1.2 - -0.2), a wide range of densities (log(n)\approx 7 - 11), and a covering fraction of ~0.15. The presence of low-ionization emission lines implies the disk component is optically thick to the continuum, and the SiIII]/CIII] ratio implies a density of 10^10 - 10^10.25 cm^-3. A low ionization parameter (log(U)=-3) is inferred for the intermediate-ionization lines, unless the continuum is ``filtered'' through the wind before illuminating the intermediate-line emitting gas, in which case log(U)=-2.1. The location of the emission regions was inferred from the photoionization modeling and a simple ``toy'' dynamical model. A large black hole mass (1.3 x 10^8 M_\odot) radiating at 11% of the Eddington luminosity is consistent with the kinematics of both the disk and wind lines, and an emission radius of ~10^4 R_S is inferred for both. We compare these results with previous work and discuss implications.Comment: 45 pages, 15 figures (4 color), accepted for publication in ApJ, abstract shortene

The management and cost of surgical site infection in patients undergoing surgery for spinal metastasis

Background Surgical site infection (SSI) is a serious potential complication of spinal surgery. SSI can impact significantly on in-patient hospitalisation and the costs associated with extra care. Aim To investigate the management of patients experiencing SSI following surgery for spinal metastatic tumours, and to estimate the costs associated with SSI in this context. Methods Patients experiencing SSI following spinal tumour surgery at a large spinal surgery centre between January 2009 and December 2012 were identified. Existing case notes were reviewed and patient and procedural data, details of the infection and treatment interventions were collected. A bottom-up approach to calculating costs associated with infection was used for patients experiencing SSI and compared with a quasi-random sample of similar patients without SSI. Findings The mean cost of treating patients with SSI was significantly greater than costs associated with those without SSI (p=0.019). Mean cost of in-patient hospital stay was 60% higher in patients with SSI compared to those without SSI (p=0.004). In-patient hospital stay alone accounted for 59% of total costs. Return to theatre was the second most costly intervention overall, accounting for 38% of costs, and was the most expensive single intervention involved in the treatment of SSI. Conclusion SSI significantly increases healthcare costs for patients undergoing surgery for spinal metastasis, with prolonged in-patient hospitalisation and return to theatre for wound management being major contributors. The actual total cost to society derived from SSI in this patient group is likely to be far beyond just the direct costs to healthcare providers

Letters to the Editor

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65933/1/j.1528-1157.1995.tb00479.x.pd

Developmental trends in voice onset time: some evidence for sex differences

This study reports on an investigation into the voice onset time (VOT) patterns of the plosives /p b t d/ in a group of 30 children aged 7 (n = 10), 9 (n = 10) and 11 (n = 10) years. Equal numbers of girls and boys participated in the study. Each child named a series of letter objects to elicit /p b t d/ in a syllable onset position with a fixed vowel context. VOT data were examined for age, sex and plosive differences with the following hypotheses: Firstly, that there would be sex differences in the VOT patterns of preadolescent children. Secondly, that the sex differences in VOT patterns would be linked to age and development, and that these would eventually become marked by the age of 11 years, by which time adult-like VOT values should have been achieved. Finally, that the extent of sex and age differences would be dependent upon the plosive being investigated. Results indicated patterns of decrease with age in the VOT values of /p b/ for the boys, with some evidence of increases in the VOT values of /t/ for the girls. In addition, 'voiced' and 'voiceless' cognates showed a more marked bimodal distribution in the girls' VOT patterns. This bimodal distribution was investigated by examining the degree of difference between the VOT values of voiced and voiceless cognate pairs /p b/ and /t d/, and examining the effects of age, sex and cognate pair. These results indicated that more marked sex differences in the 'voiced'/'voiceless' contrast emerged between the data of the 9- and 11-year-olds, a pattern, which was more marked for the alveolar plosives. These preliminary results confirmed all three hypotheses. The findings are presented and discussed both within a developmental and sociophonetic framework

AKT-independent PI3-K signaling in cancer - emerging role for SGK3

The phosphoinositide 3-kinase (PI3-K) signaling pathway plays an important role in a wide variety of fundamental cellular processes, largely mediated via protein kinase B/v-akt murine thymoma viral oncogene homolog (PKB/AKT) signaling. Given the crucial role of PI3-K/AKT signaling in regulating processes such as cell growth, proliferation, and survival, it is not surprising that components of this pathway are frequently dysregulated in cancer, making the AKT kinase family members important therapeutic targets. The large number of clinical trials currently evaluating PI3-K pathway inhibitors as a therapeutic strategy further emphasizes this. The serum- and glucocorticoid-inducible protein kinase (SGK) family is made up of three isoforms, SGK1, 2, and 3, that are PI3-K-dependent, serine/threonine kinases, with similar substrate specificity to AKT. Consequently, the SGK family also regulates similar cell processes to the AKT kinases, including cell proliferation and survival. Importantly, there is emerging evidence demonstrating that SGK3 plays a critical role in AKT-independent oncogenic signaling. This review will focus on the role of SGK3 as a key effector of AKT-independent PI3-K oncogenic signaling

Listeriolysin S, a Novel Peptide Haemolysin Associated with a Subset of Lineage I Listeria monocytogenes

peer-reviewedStreptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related peptides are produced by GAS and related streptococci only, there is evidence to suggest that a number of the most notorious Gram-positive pathogenic bacteria, including Listeria monocytogenes, Clostridium botulinum and Staphylococcus aureus, produce related peptides. The distribution of the L. monocytogenes cluster is particularly noteworthy in that it is found exclusively among a subset of lineage I strains; i.e., those responsible for the majority of outbreaks of listeriosis. Expression of these genes results in the production of a haemolytic and cytotoxic factor, designated Listeriolysin S, which contributes to virulence of the pathogen as assessed by murine- and human polymorphonuclear neutrophil–based studies. Thus, in the process of establishing the existence of an extended family of SLS-like modified virulence peptides (MVPs), the genetic basis for the enhanced virulence of a proportion of lineage I L. monocytogenes may have been revealed.Work is funded by the Irish Government under the National Development Plan, through a Science Foundation Ireland Investigator award to CH, PR and PC (06/IN.1/B98)

Different types of soluble fermentable dietary fibre decrease food intake, body weight gain and adiposity in young adult male rats

We thank Donna Wallace and the Rowett Animal House staff for the daily care of experimental rats, body weight and food intake measurements and MRI scanning, Vivien Buchan and Donna Henderson of the Rowett Analytical Department for proximate analyses and SCFA GC, and Andrew Chappell for conducting the beta-glucan analysis. This research was funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division.Peer reviewedPublisher PD