7 research outputs found
An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline
- Author
- Publication venue
- Nature Research
- Publication date
- 01/01/2020
- Field of study
Tauopathies including Alzheimer’s disease (AD) are marked by the accumulation of aberrantly modified tau proteins. Acetylated tau, in particular, has recently been implicated in neurodegeneration and cognitive decline. HDAC6 reversibly regulates tau acetylation, but its role in tauopathy progression remains unclear. Here, we identified an HDAC6-chaperone complex that targets aberrantly modified tau. HDAC6 not only deacetylates tau but also suppresses tau hyperphosphorylation within the microtubule-binding region. In neurons and human AD brain, HDAC6 becomes co-aggregated within focal tau swellings and human AD neuritic plaques. Using mass spectrometry, we identify a novel HDAC6-regulated tau acetylation site as a disease specific marker for 3R/4R and 3R tauopathies, supporting uniquely modified tau species in different neurodegenerative disorders. Tau transgenic mice lacking HDAC6 show reduced survival characterized by accelerated tau pathology and cognitive decline. We propose that a HDAC6-dependent surveillance mechanism suppresses toxic tau accumulation, which may protect against the progression of AD and related tauopathies
Enthalpies of the reactions of synthesis of isomeric poly-o-hydroxyamides in solution
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Using 2-pyrrolidone in liquid extraction and extractive rectification: A review
- Author
- A.A. Gaile
- A.I. Blakhin
- D.I. Randall
- E. M. Chartov
- E.M. Chartov
- F.P. Sidel’kovskaya
- G. Banhedyl
- G.E. Beekhuis
- H.E. Affsprung
- I.F. Blockwell
- J. Soika
- J.A. Riddick
- J.A. Walmsley
- J.E. Barry
- J.M. Brown
- L.J. Lohr
- M. I. Zaretskii
- M.I. Zaretskii
- M.J. Davis
- M.L. Kolesov
- N.V. Riyds
- P. Pirilä-Honkanen
- R.E. Serebryakov
- R.E.W. Hopmann
- S.Z. Taits
- V. V. Rusak
- V.A. Pal’m
- V.G. Podolyak
- V.G. Podolyak
- W. Klemperer
- Publication venue
- 'Allerton Press'
- Publication date
- Field of study
Behavioral and neurobiological characteristics influencing social hierarchy formation in female cynomolgus monkeys
- Author
- A. Bennett
- Abbott
- Bernstein
- Bernstein
- Bernstein
- Berton
- Cawthon-Lang
- Czoty
- Czoty
- Dalley
- Davis
- Dray
- Fekkes
- Filipenko
- Frankle
- Gartlan
- Golub
- Goo
- Grant
- H.D. Gage
- Higley
- Higley
- Higley
- Higley
- Higley
- J.R. Kaplan
- Kaplan
- Kaplan
- Kaplan
- Kaplan
- Kaplan
- Kaplan
- Kent
- Kinnally
- Laruelle
- Logan
- Lundquist
- M. Icenhower
- M.A. Nader
- Mann
- Mash
- Mendoza
- Miczek
- Miczek
- Miczek
- Milak
- Moeller
- Moeller
- Morgan
- Morgan
- N.V. Riddick
- P.J. Pierre
- P.K. Garg
- P.W. Czoty
- Paaver
- Pattij
- Raleigh
- Raleigh
- S. Garg
- S.H. Nader
- Sapolsky
- Sell
- Shively
- Shively
- Shively
- Tai
- Talbot
- Unis
- Virgin
- Westergaard
- Wilson
- Yamamoto
- Yodyingyuad
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Understanding the interactions between tris(pentafluoroethyl)-trifluorophosphate-based ionic liquid and small molecules from molecular dynamics simulation
- Author
- A. Marciniak
- A.A.H. Pádua
- A.P. Lyubartsev
- B. Chen
- B.R. Mellein
- C. Cadena
- C. Schroder
- C. Yao
- C.G. Hanke
- C.G. Hanke
- D. Blanco
- D. Blanco
- D.S. Silvester
- E.J. Maginn
- G. Kaminski
- H.C.J. Berendsen
- I. Minami
- J.A. Riddick
- J.G. Huddleston
- J.J. Wang
- J.L. Anthony
- J.M. Glenn
- J.M. Stubbs
- J.N. CanongiaLopes
- J.N.A. CanongiaLopes
- L. Cammarata
- L. William
- M. Druschler
- M. Freemantle
- M. Lopez-Pastor
- M. Moreno
- M. Zoubi Al
- M.J. Earle
- M.J. Muldoon
- M.P. Allen
- N.V. Ignat’ev
- O. Maass
- P. Husson
- P.M. Mancini
- Q.G. Zhang
- R. Al-Salman
- R.M. Kennedy
- S. Brautigam
- S.J. Weiner
- S.J. Zhang
- S.J. Zhang
- T.I. Morrow
- W. Jiang
- W.D. Cornell
- X. Zhong
- X.C. Zhang
- X.C. Zhang
- X.P. Wu
- X.P. Wu
- XiaoChun Zhang
- XiaoMin Liu
- Y. Deng
- Y. Wang
- Y.J. Xu
- Z.P. Liu
- Z.P. Liu
- ZhiPing Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science. © The Author(s) 2019. Published by Oxford University Press
Biological Effects of Acetamide, Formamide, and Their Mono and Dimethyl Derivatives: An Update
- Author
- Abrams J.S.
- Acquavella J.F.
- Adams W.J.
- Aguilera A.
- Amatimaggio F.
- Ammon R.H.
- Andrews P.W.
- Angerer J.
- Arancia G.
- Arni P.
- Arundel C
- Atkinson R.
- Avila L.Z.
- Babu G.R.V.
- Bardodej Z.
- Batiste-Alentorn M.
- Batiste-Alentorn M.
- Batiste-Alentorn M.
- Belousov Yu.
- Berger H.
- Berman I.J.
- Bhagwatwar H.P.
- Bill C.A.
- Bittersohl G.
- Blum D.J.W.
- Bochkov N.P.
- Borenfreund E.
- Borni P.J.A.
- Bosco M.
- Boyd D.
- Boyle C.C.
- Bragadin M.
- Brams A.
- Branca T.
- Buylaert W.
- Cai S.X.
- Calvert G.M.
- Camarasa J.G.
- Carere A.
- Carter J.L.
- Cary R.
- Casal Lareo
- Casal Lareo A.
- Catenacci G.
- Catenacci G.
- Chang M.J.W.
- Chanh P.H.
- Chapatwala K.D.
- Chapatwala K.D.
- Chemical Hazard USEPA
- Chieli E.
- Chieli E.
- Chow Y.L.
- Christian J.A.
- Chromek J.
- Cirla A. M.
- Clagett-Carr K.
- Collins W.J.
- Consuegra S.
- Cordeiro R.F.
- Cox N.H.
- Cragin D.W.
- Crebelli R.
- Cross H.
- Csanády G. A.
- Cucco C
- Curtis C
- Damali K.R.
- Daston G.P.
- Davison K. L.
- Del Bufalo D.
- Desesso J.M.
- Dicken CM.
- Dierickx P.J.
- Dobias L.
- Donald J.M.
- Dorado G.
- Doxtader K.G.
- Dresser T.H.
- Dubow M.S.
- Ducatman A.M.
- Ducatman A.M.
- Dybing E.
- Egyed M.N.
- Eisenreich S.J.
- El Jay A.
- El-Faham T.H.
- Ennever F.K.
- Eton O.
- Ettinger D.S.
- Ettinger D.S.
- Fahrig R.
- Fahy G.M.
- Fail P.A.
- Fallon R.D.
- Ferenz R.L.
- Ferrari L.A.
- Ferreiro J. A.
- Fiorito A.
- Fleming L.E.
- Flint O. P.
- Foureman P.
- Francis G.E.
- Franquemont D.W.
- Friedman J.
- Friedman-Jimenez G.
- Fritzenschaf H.
- Frumin E.
- Fujishiro K.
- Gao X.
- Gao X.Q.
- Gartzke J.
- Gate E.N.
- Gautheron P
- Geddes J.D.
- Gerald L. Kennedy
- Gescher A.
- Ghisalba O.
- Gibson N.B.
- Gichner T.
- Gilleron L.
- Gorniak S.L.
- Greco C
- Groth G.
- Groth G.
- Grunt T.W.
- Guilbaud N.F.
- Guirguis S.S.
- Gupta S.
- Guyot J.P.
- Guyot J.P.
- Haag W.R.
- Haber I.
- Hallows K.R.
- Hamm A.
- Han D.H.
- Hansen E.
- Harpur E.S.
- Hassan H.T.
- Hayes S.
- Hayon E.
- Heindorff K.
- Hellmer L.
- Hellwig J.
- Hodson P.V.
- Hodson R.C.
- Hofmann A.
- Hofmann H. T.
- Hooper K.
- Huang J-F
- Huang P.H.
- Hughes J.S.
- Hundley S. G.
- Hurtt M. E.
- Hurtt M. E.
- Hyland R.
- Ikeda H.
- Imazu K.
- Imazu K.
- Itoh H.
- Ivanova N.I.
- Ivanovich E.
- Ivanovich E.
- Izquierdo D.J.
- Jacobs G. A.
- Jacobs G.A.
- Jacobs G.A.
- Jeffers R J.
- Johannsen F.R.
- Johnson E.M.
- Kamakura M.
- Kamakura M.
- Katosova L.D.
- Kawai T.
- Kawai T.
- Kawalek J.C.
- Kawasaki M.
- Kelich S.L.
- Kennedy A.R.
- Kennedy G. L.
- Kennedy G. L.
- Kennedy G.L.
- Kestell P.
- Kestell P.
- Kimber I.
- Kinney L.A.
- Klamerus K.
- Klaunig J.E.
- Klavis G.
- Klebe R J.
- Klimisch H.J.
- Kloecking H.P.
- Klopman G.
- Klug S
- Klug S.
- Kola I.
- Koudela K.
- Koymans L.
- Kronauer K.
- Laity J.L.
- Lake P.E.
- Langdon S.P.
- Langdon S.P.
- Langdon S.P.
- Larsen J.
- Lashmar U.T.
- Laudonio N.
- Laughrea M.
- Lauwerys R. R.
- Lazarev N.V.
- Le Tallec N.
- LeBlanc G.A.
- Leenheer J.A.
- Levine A.E.
- Linardi V. R.
- Liu M.
- Liu S.L.
- Loos H.
- Lyman W.J.
- Major J.
- Malley L. A.
- Malley L.A.
- Marino G.
- Massman W.
- Mastrangelo G.
- Masuda Y.
- Mayer V.W.
- McCabe D.
- McGuire W.P.
- McQueen C.A.
- McVie J.G.
- Melani C
- Menegola E.
- Meng X.
- Meylan W. M.
- Mirkova E. T.
- Misik V.
- Mitchell A.D.
- Mitchell I. G.
- Molinari S.
- Montaguti P.
- Montelius J.
- Moore E.E.
- Mori H.
- Morita T.
- Morris O. N.
- Mortelmans K.
- Mraz J.
- Mraz J.
- Mraz J.
- Mukaida T.
- Mulder K.M.
- Mulder K.M.
- Myhr B.C.
- Naguib F.N.M.
- Nakamura S.
- Narayanasamy K.
- Nawaz M.S.
- Newell D.
- Nicolas F.
- Nicoletti G.
- Nishiuchi Y.
- Orser C. S.
- Osswald H.
- O’Donoghue J.L.
- O’Dwyer P. J.
- O’Dwyer PJ.
- Palmen N. G.
- Panchagnula R.
- Parodi S.
- Pearson P. G.
- Pearson P. G.
- Pearson P.G.
- Pearson P.G.
- Pearson P.G.
- Phipps G.L.
- Pienta R.J.
- Pitts J. N.
- Poelmans L.
- Poirier S.H.
- Porter W.R.
- Posada J.G.
- Price C. J.
- Proskuriakov S.I.
- Qin Y.H.
- Ramierez F.
- Ramp U
- Redlich C.A.
- Reed K.W.
- Renn L.
- Rhomberg L.
- Richards F.M.
- Rickard L.B.
- Riddick J. A.
- Ritschel W. A.
- Ritschel W.A.
- Roberts B.L.
- Rossell M.T.
- Roure M. B.
- Rowinsky E.K.
- Saillenfait A. M.
- Sakai T.
- Sakai T.
- Santoni G.
- Santos D.
- Satory E.
- Saunders D. G.
- Scailteur V.
- Scailteur V.
- Scansetti G.
- Schiestl R.H.
- Schultze A. E.
- Schumilina A. V.
- Scotlandi K.
- Sebaugh J.L.
- Seiji K.
- Sharata H.H.
- Shaw A.J.
- Shubat P.J.
- Silvia M.
- Simonsen L.
- Singh J.
- Sitjes J.
- Slatter J.G.
- Smoryzanova O.A.
- Smyth H.F.
- Solomon H. M.
- Solt D.
- Somay C
- Sorkina N.S.
- Sram R J.
- Stadler J. C.
- Steinborn J.
- Stratton G.W.
- Stratton G.W.
- Stratton G.W.
- Sullivan F.M.
- Svensson C.K.
- Swann R.L.
- Swerdlow A.J.
- Taft R. W.
- Takayama S.
- Tauer K.
- Taylor C.W.
- Tchekmedyian N.S.
- Thonke M.
- Thorn N. S.
- Todd M.
- Tofilon PJ.
- Tonogai Y.
- Tselutin K.
- Tulip K.
- Tulip K.
- Urano K.
- Ursin C.
- Valencia R.
- Valentine R.
- Van den Bulcke M.
- Van Dongen G.A.
- Van Dyk T. K.
- Van Reijendam J.W.
- Viadro M.M.
- Vishuvajjala B.R.
- Vogel E.W.
- Vogel W.C.
- Wallace L. A.
- Walrath J.
- Wang D. H.
- Warheit D.B.
- Watkins L.F.
- Waxman S.
- Wearne S. J.
- West A.B.
- West S.D.
- Whitby H.
- Williams G. M.
- Wilson H. K.
- Woolf A.D.
- Wrbitzky R.
- Wrbitzky R.
- Wurgler F.E.
- Yanagisawa K.
- Yanase S.
- Yang C
- Yasuhara A.
- Ye G.
- Zeiger E.
- Zeng X.
- Zijlstra J.A.
- Zupi G.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study