La Metodología de Dejar Estados Unidos por Asia: Leyendo Libros de Texto Surcoreanos de Ciencias Sociales a través de Asia Como Método por Chen Kuan-Hsing

This project began as a content analysis of five South Korean high school Social Studies textbooks. Yet, it has evolved into an epistemological experiment to pursue the question of “what does it mean to leave America for Asia, at least methodologically, for the researcher who left Asia for America?” Using the textbooks as a mediating site, therefore, I articulate a process that engages with, moves toward, and develops deimperializing methodology. More specifically, I interweaveKuan-HsingChen’s Asia as Method: Toward Deimperialization (2010) with my data by analyzing the data through Asia as Method and reading and practicing Asia as Method as methodology. This allows me to move away from fixating on the West as a reference point even through my critique. Rather, I work to produce geo-historically grounded knowledge for specific interventions at this mediating site toward the movements of decolonization, de-cold war, and deimperialization. In the process, I discuss how Asia as Method as methodology provokes political, psychological, and social engagements of everyday, multiplies reference points for knowledge production, and requires a researcher to re-work on one’s subjectivity inevitably constituted by imperialism.Este proyecto comenzó como un análisis de contenido de cinco libros de texto decienciass sociales surcoreanos de Secundaria. Sin embargo, se ha convertido en un experimento epistemológico en búsca de la pregunta "¿Qué significa dejar Estados Unidos por Asia, al menos metodológicamente, para el investigador que dejó Asia por los Estados Unidos?" El uso los libros de texto como un espaciode mediación me permite articular un proceso en el que se relaciona y se mueve a desarrollarlo por la metodología de la des-imperialización. Más específicamente, realizo un entrelazado del trabajo de Kuan-Hsing Chen, Asia como Método: Hacia la Des-imperialización (2010) con mis datos. El trabajo consiste en un análisis de los datos a través de Asia como Método junto con la lectura y la práctica como metodología. Esto me permite alejarme de Occidente como un punto de referencia, incluso durante de mi crítica. Más bien, yo trabajo para producir una base de conocimiento geo-histórico firme para intervenciones específicas a través de la mediación de los movimientos de descolonización, anti-Guerra Fria y des-imperialización. En el proceso, analizo como el uso de Asia como Método como metodología provoca compromisos políticos, psicológicos y sociales de cada día, además de cómo estos compromisos multiplican los puntos de vista para la producción de conocimiento y requieren que el investigador revise su propia subjetividad, algo inevitablemente constituido por la especificidad del imperialismo

Un/learning Habituation of Body-Mind Binary through the Teaching/Learning Body/Mind

A complex critique of how society constructs women of color in the academy combines with deeply personal interludes and a polyphony of scholarly voices to demonstrate ways that their objectified bodies can not only resist but also improvise as they question what it means to be different

factor 1α in precancerous nodules with telomere

Increased expression of stathmin and elongatio

Inhibition of Sodium-Glucose Cotransporter-2 during Serum Deprivation Increases Hepatic Gluconeogenesis via the AMPK/AKT/FOXO Signaling Pathway

Background Sodium-dependent glucose cotransporter 2 (SGLT2) mediates glucose reabsorption in the renal proximal tubules, and SGLT2 inhibitors are used as therapeutic agents for treating type 2 diabetes mellitus. This study aimed to elucidate the effects and mechanisms of SGLT2 inhibition on hepatic glucose metabolism in both serum deprivation and serum supplementation states. Methods Huh7 cells were treated with the SGLT2 inhibitors empagliflozin and dapagliflozin to examine the effect of SGLT2 on hepatic glucose uptake. To examine the modulation of glucose metabolism by SGLT2 inhibition under serum deprivation and serum supplementation conditions, HepG2 cells were transfected with SGLT2 small interfering RNA (siRNA), cultured in serum-free Dulbecco’s modified Eagle’s medium for 16 hours, and then cultured in media supplemented with or without 10% fetal bovine serum for 8 hours. Results SGLT2 inhibitors dose-dependently decreased hepatic glucose uptake. Serum deprivation increased the expression levels of the gluconeogenesis genes peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α), glucose 6-phosphatase (G6pase), and phosphoenolpyruvate carboxykinase (PEPCK), and their expression levels during serum deprivation were further increased in cells transfected with SGLT2 siRNA. SGLT2 inhibition by siRNA during serum deprivation induces nuclear localization of the transcription factor forkhead box class O 1 (FOXO1), decreases nuclear phosphorylated-AKT (p-AKT), and p-FOXO1 protein expression, and increases phosphorylated-adenosine monophosphate-activated protein kinase (p-AMPK) protein expression. However, treatment with the AMPK inhibitor, compound C, reversed the reduction in the protein expression levels of nuclear p-AKT and p-FOXO1 and decreased the protein expression levels of p-AMPK and PEPCK in cells transfected with SGLT2 siRNA during serum deprivation. Conclusion These data show that SGLT2 mediates glucose uptake in hepatocytes and that SGLT2 inhibition during serum deprivation increases gluconeogenesis via the AMPK/AKT/FOXO1 signaling pathway

Targeted exome sequencing for the identification of a protective variant against Internet gaming disorder at rs2229910 of neurotrophic tyrosine kinase receptor, type 3 (NTRK3): A pilot study

Background and aims Internet gaming disorder (IGD) has gained recognition as a potential new diagnosis in the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders, but genetic evidence supporting this disorder remains scarce. Methods In this study, targeted exome sequencing was conducted in 30 IGD patients and 30 control subjects with a focus on genes linked to various neurotransmitters associated with substance and non-substance addictions, depression, and attention deficit hyperactivity disorder. Results rs2229910 of neurotrophic tyrosine kinase receptor, type 3 (NTRK3) was the only single nucleotide polymorphism (SNP) that exhibited a significantly different minor allele frequency in IGD subjects compared to controls (p = .01932), suggesting that this SNP has a protective effect against IGD (odds ratio = 0.1541). The presence of this potentially protective allele was also associated with less time spent on Internet gaming and lower scores on the Young’s Internet Addiction Test and Korean Internet Addiction Proneness Scale for Adults. Conclusions The results of this first targeted exome sequencing study of IGD subjects indicate that rs2229910 of NTRK3 is a genetic variant that is significantly related to IGD. These findings may have significant implications for future research investigating the genetics of IGD and other behavioral addictions