Application of Incident Command Structure to clinical trial management in the academic setting: principles and lessons learned

Background Clinical trial success depends on appropriate management, but practical guidance to trial organisation and planning is lacking. The Incident Command System (ICS) is the ‘gold standard’ management system developed for managing diverse operations in major incident and public health arenas. It enables effective and flexible management through integration of personnel, procedures, resources, and communications within a common hierarchical organisational structure. Conventional ICS organisation consists of five function modules: Command, Planning, Operations, Logistics, and Finance/Administration. Large clinical trials will require a separate Regulatory Administrative arm, and an Information arm, consisting of dedicated data management and information technology staff. We applied ICS principles to organisation and management of the Prehospital Use of Plasma in Traumatic Haemorrhage (PUPTH) trial. This trial was a multidepartmental, multiagency, randomised clinical trial investigating prehospital administration of thawed plasma on mortality and coagulation response in severely injured trauma patients. We describe the ICS system as it would apply to large clinical trials in general, and the benefits, barriers, and lessons learned in utilising ICS principles to reorganise and coordinate the PUPTH trial. Results Without a formal trial management structure, early stages of the trial were characterised by inertia and organisational confusion. Implementing ICS improved organisation, coordination, and communication between multiple agencies and service groups, and greatly streamlined regulatory compliance administration. However, unfamiliarity of clinicians with ICS culture, conflicting resource allocation priorities, and communication bottlenecks were significant barriers. Conclusions ICS is a flexible and powerful organisational tool for managing large complex clinical trials. However, for successful implementation the cultural, psychological, and social environment of trial participants must be accounted for, and personnel need to be educated in the basics of ICS

Implications of the X-ray Variability for the Mass of MCG-6-30-15

The bright Seyfert 1 galaxy \mcg shows large variability on a variety of time scales. We study the \aproxlt 3 day time scale variability using a set of simultaneous archival observations that were obtained from \rxte and the {\it Advanced Satellite for Cosmology and Astrophysics} (\asca). The \rxte\ observations span nearly $10^6$ sec and indicate that the X-ray Fourier Power Spectral Density has an rms variability of 16%, is flat from approximately 10^{-6} - 10^{-5} Hz, and then steepens into a power law $\propto f^{-\alpha}$ with \alpha\aproxgt 1. A further steepening to $\alpha \approx 2$ occurs between 10^{-4}-10^{-3} Hz. The shape and rms amplitude are comparable to what has been observed in \ngc and \cyg, albeit with break frequencies that differ by a factor of 10^{-2} and 10^{4}, respectively. If the break frequencies are indicative of the central black hole mass, then this mass may be as low as $10^6 {\rm M}_\odot$. An upper limit of $\sim 2$ ks for the relative lag between the 0.5-2 keV \asca band compared to the 8-15 keV \rxte band was also found. Again by analogy with \ngc and \cyg, this limit is consistent with a relatively low central black hole mass.Comment: 5 pages, 3 figures, LaTeX, uses emulateapj.sty and apjfonts.sty, revised version, accepted for publication in ApJ Letter

Basic Astronomy Labs

Providing the tools and know-how to apply the principles of astronomy first-hand, these 43 laboratory exercises each contain an introduction that clearly shows budding astronomers why the particular topic of that lab is of interest and relevant to astronomy. About one-third of the exercises are devoted solely to observation, and no mathematics is required beyond simple high school algebra and trigonometry.Organizes exercises into six major topics—sky, optics and spectroscopy, celestial mechanics, solar system, stellar properties, and exploration and other topics—providing clear outlines of what is involved in the exercise, its purpose, and what procedures and apparatus are to be used. Offers variations on standard and popular exercises, and includes many that are new and innovative, such as The Messier List which helps users discover basic facts about the Milky Way Galaxy by plotting these objects on a star chart; Motions of Earth demonstrates just how fast the Earth is moving through space and in which direction it is going, and; Radioactivity and Time which measures the half-life of a short-lived isotope, and consider radioactive dating and heating of celestial bodies. Includes a guide to astronomical pronunciations, a guide to the constellations, spectral classifications, quotes on science, and more. For astronomers

Direct velocity feedback versus a geometric controller design of remotely located vibration control systems

Proceedings of the 5th International Conference on Structural Engineering, Mechanics and Computation, SEMC 2013The mitigation of human induced vibrations in floors continues to be a key area of research particularly as a result of advancement in material and design technologies enabling the design of light, slender and more open plan structures. These floors are typically characterised by low and close natural frequencies as well as low modal damping ratios, and these combinations of factors contribute to their increased susceptibility to human induced vibrations. Amongst the remedial measures pursued to enhance their vibration serviceability performance, active vibration control (AVC) technologies are emerging as a viable technology and predominantly direct output feedback approaches have been pursued in past analytical studies and field trials. It has often been assumed that actuators and sensors can be located where vibration attenuation is desired and this may not always be feasible. The research work presented in this paper compares the vibration mitigation performances of the direct velocity feedback scheme that has been extensively used in past floor vibration control researches against a geometric controller design approach that has been developed to provide a design freedom for reducing vibration in both local and remote locations. The geometric controller design approach assumes the inability to locate the actuators and sensors at the remote location but acknowledges that this measurement can be obtained during the commissioning stage and used during the design phase to enhance both local and remote locations. All the analytical and experimental studies are based on a laboratory structure. The work demonstrates comparable vibration mitigation performances of the dominant mode of vibration of the laboratory structure for both approaches but also demonstrates potential for additional enhancement to the second vibration mode of the laboratory structure with the geometric controller design approach. Approximately 20-25 dB attenuation in the first and second vibration modes of the laboratory structure were achieved. © 2013 Taylor & Francis Group, London, UK.The authors would like to acknowledge the financial assistance provided by the UK Engineering and Physical Sciences Research Council (EPSRC) through a responsive mode grant entitled “Active Control of Human-Induced Vibration” (Ref: EP/H009825/1), Leadership Fellowship grant entitled “Advanced Technologies for Mitigation of Human-Induced Vibration” (Ref: EP/J004081/1) and Platform Grant entitled “Dynamic Performance of Large Civil Engineering Structures: An Integrated Approach to Management, Design and Assessment” (Ref: EP/G061130/1)

A concise synthesis of a methyl ester 2-resorcinarene: A chair-conformation macrocycle

Anions are important hydrogen bond acceptors in a range of biological, chemical, environ-mental and medical molecular recognition processes. These interactions have been exploited for the design and synthesis of ditopic resorcinarenes as the hydrogen bond strength can be tuned through the modification of the substituent at the 2-position. However, many potentially useful compounds, especially those incorporating electron-withdrawing functionalities, have not been prepared due to the challenge of their synthesis: their incorporation slows resorcinarene formation that is accessed by electrophilic aromatic substitution. As part of our broader campaign to employ resorcinarenes as selective recognition elements, we need access to these specialized materials. In this article, we report a straightforward synthetic pathway for obtaining a 2-(carboxymethyl)-resorcinarene, and resorcinarene esters in general. We discuss the unusual conformation it adopts and propose that this arises from the electron-withdrawing nature of the ester substituents that renders them better hydrogen bond acceptors than the phenols, ensuring that each of them acts as a donor only. Density Functional Theory (DFT) calculations show that this conformation arises as a consequence of the unusual configurational isomerism of this compound and interruption of the archetypal hydrogen bonding by the ester functionality

Intrinsic Absorption Lines in Seyfert 1 Galaxies. I. Ultraviolet Spectra from the Hubble Space Telescope

We present a study of the intrinsic absorption lines in the ultraviolet spectra of Seyfert 1 galaxies. We find that the fraction of Seyfert 1 galaxies that show absorption associated with their active nuclei is more than one-half (10/17), which is much higher than previous estimates (3 - 10%) . There is a one-to-one correspondence between Seyferts that show intrinsic UV absorption and X-ray ``warm absorbers''. The intrinsic UV absorption is generally characterized by high ionization: C IV and N V are seen in all 10 Seyferts with detected absorption (in addition to Ly-alpha), whereas Si IV is present in only four of these Seyferts, and Mg II absorption is only detected in NGC 4151. The absorption lines are blueshifted (or in a few cases at rest) with respect to the narrow emission lines, indicating that the absorbing gas is undergoing net radial outflow. At high resolution, the absorption often splits into distinct kinematic components that show a wide range in widths (20 - 400 km/s FWHM), indicating macroscopic motions (e.g., radial velocity subcomponents or turbulence) within a component. The strong absorption components have cores that are much deeper than the continuum flux levels, indicating that the regions responsible for these components lie completely outside of the broad emission-line regions. The covering factor of the absorbing gas in the line of sight, relative to the total underlying emission, is C > 0.86, on average. The global covering factor, which is the fraction of emission intercepted by the absorber averaged over all lines of sight, is C > 0.5.Comment: 56 pages, Latex, includes 4 figures (encapsulated postscript), Fig. 1 has 2 parts and Fig. 2 has 3 parts, to appear in the Astrophysical Journa