Sheridan Coliseum: Yearbook

Page 132 of the 1916 edition of The Reveille - describes the ground breaking for the new coliseum and how two gentlemen provided the $1000 that was needed after the legislature provided for$100,000.https://scholars.fhsu.edu/sheridan/1044/thumbnail.jp

Sheridan Coliseum: Yearbook

Page ninety-eight: photo captioned Enjoying IL Trovatore ; page ninety-nine: Cast for Il Trovatore; page one hundred three: the Music department; page one hundred forty-nine: photo of a women\u27s game in October 1916 with the half-finished building of Sheridan Coliseum in the background.https://scholars.fhsu.edu/sheridan/1034/thumbnail.jp

Gene and Pathway-Based Analysis: Second Wave of Genome-wide Association Studies

Despite great success of GWAS in identification of common genetic variants associated with complex diseases, the current GWAS have focused on single SNP analysis. However, single SNP analysis often identifies a number of the most significant SNPs that account for only a small proportion of the genetic variants and offers limited understanding of complex diseases. To overcome these limitations, we propose gene and pathway-based association analysis as a new paradigm for GWAS. As a proof of concept, we performed a comprehensive gene and pathway-based association analysis for thirteen published GWAS. Our results showed that the proposed new paradigm for GWAS not only identified the genes that include significant SNPs found by single SNP analysis, but also detected new genes in which each single SNP conferred small disease risk, but their joint actions were implicated in the development of diseases. The results also demonstrated that the new paradigm for GWAS was able to identify biologically meaningful pathways associated with the diseases which were confirmed by gene-set rich analysis using gene expression data

Predictors of fatigue severity in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort.

ObjectivesLongitudinal studies examining the baseline predictors of fatigue in SSc have not been reported. Our objectives were to examine the course of fatigue severity over time and to identify baseline clinical, demographic, and psychosocial predictors of sequentially obtained fatigue scores in early SSc. We also examined baseline predictors of change in fatigue severity over time.MethodsWe analyzed 1090 longitudinal Fatigue Severity Scale (FSS) scores belonging to 256 patients who were enrolled in the Genetics versus Environment in Scleroderma Outcomes Study (GENISOS). Predictive significance of baseline variables for sequentially obtained FSS scores was examined with generalized linear mixed models. Predictors of change in FSS over time were examined by adding an interaction term between the baseline variable and time-in-study to the model.ResultsThe patients' mean age was 48.6 years, 47% were Caucasians, and 59% had diffuse cutaneous involvement. The mean disease duration at enrollment was 2.5 years. The FSS was obtained at enrollment and follow-up visits (mean follow-up time = 3.8 years). Average baseline FSS score was 4.7(±0.96). The FSS was relatively stable and did not show a consistent trend for change over time (p = 0.221). In a multivariable model of objective clinical variables, higher Medsger Gastrointestinal (p = 0.006) and Joint (p = 0.024) Severity Indices, and anti-U1-RNP antibodies (p = 0.024) were independent predictors of higher FSS. In the final model, ineffective coping skills captured by higher Illness Behavior Questionnaire scores (p<0.001), higher self-reported pain (p = 0.006), and higher Medsger Gastrointestinal Severity Index (p = 0.009) at enrollment were independent predictors of higher longitudinal FSS scores. Baseline DLco % predicted was the only independent variable that significantly predicted a change in FSS scores over time (p = 0.013), with lower DLco levels predicting an increase in FSS over time.ConclusionsThis study identified potentially modifiable clinical and psychological factors that predict longitudinal fatigue severity in early SSc

Study of fuel injection and mixture formation for a gasoline direct injection engine

Future requirements for lower automotive emissions have lead to the development of new internal combustion (IC) engine technologies. Gasoline Direct Injection (GDI), for example, is one of these promising new IC engine concepts. It offers the opportunity of increased efficiency through unthrottled operation. However, the realisation of this concept is critically dependent on the in-cylinder mixture formation, especially in the late injection/lean operation mode. Ideally, this would require a precise stratification of the in-cylinder fuel-air mixture in 3 distinct zones: an ignitable pocket located at the spark plug, surrounded by a stoichiometric mixture of fuel and air, encompassed by air. To enable this stratification, the GDI concept utilises advanced injector technology. Phase Doppler Anemometry (PDA), Planar Laser-Induced Fluorescence (PLIF) and the combination of PLIF and Mie scattering in the Laser-Sheet Dropsizing (LSD) technique, have been applied to sprays in the past to obtain dropsize information and study the mixture formation process. These new GDI sprays are denser, their droplet sizes are smaller and they evaporate faster, and as such, place us at the limit of the validity of these measurements techniques. The diagnostics were applied to a GDI spray in a pressure vessel for realistic in-cylinder conditions, ranging from supercooled to superheated environments. Tracer evaporation issues in the PLIF technique were resolved by using a dual tracer system. The study showed that the LSD technique provided good quantitative data in low evaporation regimes. In highly evaporating regimes, the technique still gave reliable dropsize data for the early stages of the injection, but was limited afterwards by vapour-phase contribution to the fluorescence signal. Variations between PDA data and LSD results also suggested a deviation of the Mie scattering signal from the assumed d2 dependence. This was further investigated and was found to be true for small droplets (d/?. <0.2). This source of error might be improved by using a different observation angle. High density seriously compromises the accuracy of PDA, whilst its effect through multiple scattering is of second order for the LSD technique. In low evaporating regimes, LSD has the overall advantage of being a 2-D measurement technique, and will yield data with a maximum error of 30% in dense parts of the spray where PDA data is totally unreliable. If the spray evaporates quickly, PLIF by itself is an appropriate tool for following the air-fuel mixture, because short droplet lifetimes limit the 2-phase flow behaviour of the spray. Particle Image Velocimetry (PIV), the LSD technique and equivalence ratio LIF measurements were applied to a BMW single cylinder optical GDI engine. The early injection operation showed no particular issues. However, the results obtained in the late injection highlighted the poor mixing and inappropriate stratification.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

ANKH variants associated with ankylosing spondylitis: gender differences

The ank (progressive ankylosis) mutant mouse, which has a nonsense mutation in exon 12 of the inorganic pyrophosphate regulator gene (ank), exhibits aberrant joint ankylosis similar to human ankylosing spondylitis (AS). We previously performed family-based association analyses of 124 Caucasian AS families and showed that novel genetic markers in the 5' flanking region of ANKH (the human homolog of the murine ank gene) are modestly associated with AS. The objective of the present study was to conduct a more extensive evaluation of ANKH variants that are significantly associated with AS and to determine whether the association is gender specific. We genotyped 201 multiplex AS families with nine ANKH intragenetic and two flanking microsatellite markers, and performed family-based association analyses. We showed that ANKH variants located in two different regions of the ANKH gene were associated with AS. Results of haplotype analyses indicated that, after Bonferroni correction, the haplotype combination of rs26307 [C] and rs27356 [C] is significantly associated with AS in men (recessive/dominant model; P = 0.004), and the haplotype combination of rs28006 [C] and rs25957 [C] is significantly associated with AS in women (recessive/dominant model; P = 0.004). A test of interaction identified rs26307 (i.e. the region that was associated in men with AS) as showing a difference in the strength of the association by gender. The region associated with AS in women only showed significance in the test of interaction among the subset of families with affected individuals of both genders. These findings support the concept that ANKH plays a role in genetic susceptibility to AS and reveals a gender–genotype specificity in this interaction

Sex Differences in Augmentation Index in Response to Acute Dynamic Exercise

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