Late Cenozoic exhumation and drainage evolution of the Central and Western Alps revealed by detrital thermochronology

The relations between climate, tectonics and topographic changes are still not fully understood. During the Late Cenozoic, the glacial cycles affecting the European Alps are held responsible for a strong increase in Alpine relief. Detrital samples of the circum-Alpine foreland depocenters were analyzed with detrital thermochronology, namely the apatite fission track and (U-Th-Sm)/He dating methods. The new thermochronological data contradict a long-term exhumational equlibrium for the Central and Western Alps, as frequently postulated in Alpine literature. In fact, distinct Alpine regions differ severely in their exhumation pattern. Also the drainage pattern was more complex than previously assumed, with a proto-Rhine draining via the Rhine Graben towards the North Sea in Pliocene times

An analytical Model which Determines the Apparent T1 for Modified Look-Locker Inversion Recovery (MOLLI) -- Analysis of the Longitudinal Relaxation under the Influence of Discontinuous Balanced and Spoiled Gradient Echo Readouts

Quantitative nuclear magnetic resonance imaging (MRI) shifts more and more into the focus of clinical research. Especially determination of relaxation times without/and with contrast agents becomes the foundation of tissue characterization, e.g. in cardiac MRI for myocardial fibrosis. Techniques which assess longitudinal relaxation times rely on repetitive application of readout modules, which are interrupted by free relaxation periods, e.g. the Modified Look-Locker Inversion Recovery = MOLLI sequence. These discontinuous sequences reveal an apparent relaxation time, and, by techniques extrapolated from continuous readout sequences, the real T1 is determined. What is missing is a rigorous analysis of the dependence of the apparent relaxation time on its real partner, readout sequence parameters and biological parameters as heart rate. This is provided in this paper for the discontinuous balanced steady state free precession (bSSFP) and spoiled gradient echo readouts. It turns out that the apparente longitudinal relaxation rate is the time average of the relaxation rates during the readout module, and free relaxation period. Knowing the heart rate our results vice versa allow to determine the real T1 from its measured apparent partner.Comment: 1 Figur

Exploring isospin, strangeness and charm distillation in heavy ion collisions

The isospin and strangeness dimensions of the Equation of State are explored. RIA and the SIS200 accelerator at GSI will allow to explore these regions in compressed baryonic matter. 132 Sn + 132 Sn and 100 Sn + 100 Sn collisions as well as the excitation functions of K/pi, Lambda/pi and the centrality dependence of charmonium suppression from the UrQMD and HSD transport models are presented and compared to data. Unambiguous proof for the creation of a 'novel phase of matter' from strangeness and charm yields is not in sight

Survival and Years of Good Life in Finland in the very long run

In this paper we apply the recently developed wellbeing indicator ‘Years of Good Life’ (YoGL) to Finland, which has the world’s longest annual demographic time series starting in 1722. We combine this with scenarios up to 2100 as developed under the SSP (Shared Socioeconomic Pathways) framework. YoGL is based primarily on the trend in life expectancy but it also considers age-specific proportions of persons above critical levels of quality of life indicators (using the Sullivan method). Since estimating these indicators for historical populations is a major challenge, the paper uses a wide array of sources to come up with a first crude estimation of how quality of life has changed in Finland over the centuries

Patronage, Science and Politics in Habsburg Empire and in the First Republic of Austria

This paper analyzes the patronage of the sciences by Vienna’s liberal bourgeoisie in the days of the late Habsburg monarchy, a period of public and private advancements in all sciences. It specifically focuses on the establishment of scientifically highly successful prizes and institutions within the Vienna Academy of the Sciences. Regarding the research of radioactivity in particular, patronage by founding a new research institution (Institut für Radiumforschung at the Academy) triggered and incited internationally competitive research. All this came to an end in 1938.This paper analyzes the patronage of the sciences by Vienna’s liberal bourgeoisie in the days of the late Habsburg monarchy, a period of public and private advancements in all sciences. It specifically focuses on the establishment of scientifically highly successful prizes and institutions within the Vienna Academy of the Sciences. Regarding the research of radioactivity in particular, patronage by founding a new research institution (Institut für Radiumforschung at the Academy) triggered and incited internationally competitive research. All this came to an end in 1938

Measurements of complement factor H-related protein (BTA-TRAK (TM) assay) and nuclear matrix protein (NMP22 assay) - Useful diagnostic tools in the diagnosis of urinary bladder cancer?

Between 1997 and 2000 we investigated in a prospective study the voided urine samples of all consecutive patients undergoing cystoscopy independent from their clinical background (n=705) with the BTA-TRAK(TM) assay (Bard Diagnostics, Redmont, USA) detecting complement factor H-related protein (CFHrP) and the NMP22 assay (Matritech, Newton, USA) measuring nuclear matrix protein, which is supposed to be specific for bladder cancer. The individuals were divided into three groups concerning the clinical background: 233 patients had urological diseases, 268 patients had urinary bladder cancer and 150 patients had other urological malignancies. Based on the clinical findings we compared our results with well established diagnostic methods for urinary bladder cancer such as cytology and the detection of hematuria. In addition, we investigated urine samples from 30 healthy individuals and 24 patients with urinary tract infection without performing cystoscopy. Following the recommendations of the European Group on Tumor Markers we used 95% specificity for benign urological diseases and urinary tract infections, which resulted in a sensitivity of 17% for active bladder cancer for the BTA-TRAK(TM) assay and 31% for NMP22. We compared these results with the detection of hematuria (specificity: 72%) and cytology, which had a sensitivity of 64% and 89%, respectively. Subsequently, we calculated sensitivity and specificity for the detection of relapse of the disease. Again using 95% specificity, in this case for patients with no evidence of disease (NED), in patients with recurrent disease the BTA-TRAK(TM) assay showed % sensitivity as compared to 12% for the NMP22 assay. Due to an insufficient specificity and sensitivity, both tests can neither be clinically useful in screening of high risk patients, nor in primary diagnosis of bladder cancer. They cannot replace neither cystoscopy nor cytology. In the follow-up care more investigations may be necessary to prove the benefit of existing diagnostic strategies for the discrimination between active and inactive bladder cancer

Strangeness dynamics in relativistic nucleus-nucleus collision

We investigate hadron production as well as transverse hadron spectra in nucleus-nucleus collisions from 2 A.GeV to 21.3 A.TeV within two independent transport approaches (UrQMD and HSD) that are based on quark, diquark, string and hadronic degrees of freedom. The comparison to experimental data demonstrates that both approaches agree quite well with each other and with the experimental data on hadron production. The enhancement of pion production in central Au+Au (Pb+Pb) collisions relative to scaled pp collisions (the 'kink') is well described by both approaches without involving any phase transition. However, the maximum in the K+/Pi+ ratio at 20 to 30 A.GeV (the 'horn') is missed by ~ 40%. A comparison to the transverse mass spectra from pp and C+C (or Si+Si) reactions shows the reliability of the transport models for light systems. For central Au+Au (Pb+Pb) collisions at bombarding energies above ~ 5 A.GeV, however, the measured K +/- m-theta-spectra have a larger inverse slope parameter than expected from the calculations. The approximately constant slope of K+/-spectra at SPS (the 'step') is not reproduced either. Thus the pressure generated by hadronic interactions in the transport models above ~ 5 A.GeV is lower than observed in the experimental data. This finding suggests that the additional pressure - as expected from lattice QCD calculations at finite quark chemical potential and temperature - might be generated by strong interactions in the early pre-hadronic/partonic phase of central Au+Au (Pb+Pb) collisions

Strangeness dynamics and transverse pressure in relativistic nucleus-nucleus collisions

We investigate hadron production as well as transverse hadron spectra from proton-proton, proton-nucleus and nucleus-nucleus collisions from 2 A·GeV to 21.3 A·TeV within two independent transport approaches (HSD and UrQMD) that are based on quark, diquark, string and hadronic degrees of freedom. The comparison to experimental data on transverse mass spectra from pp, pA and C+C (or Si+Si) reactions shows the reliability of the transport models for light systems. For central Au+Au (Pb+Pb) collisions at bombarding energies above ~5 A·GeV, furthermore, the measured K± transverse mass spectra have a larger inverse slope parameter than expected from the default calculations. We investigate various scenarios to explore their potential effects on the K± spectra. In particular the initial state Cronin effect is found to play a substantial role at top SPS and RHIC energies. However, the maximum in the K+/..+ ratio at 20 to 30 A·GeV is missed by 40% and the approximately constant slope of the K± spectra at SPS energies is not reproduced either. Our systematic analysis suggests that the additional pressure - as expected from lattice QCD calculations at finite quark chemical potential µq and temperature T- should be generated by strong interactions in the early pre-hadronic/partonic phase of central Au+Au (Pb+Pb) collisions