Distance and Reddening of the Isolated Dwarf Irregular Galaxy NGC 1156

We present a photometric estimation of the distance and reddening values to the dwarf irregular galaxy NGC 1156, which is one of the best targets to study the isolated dwarf galaxies in the nearby universe. We have used the imaging data sets of the Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) High Resolution Channel (HRC) of the central region of NGC 1156 (26" X 29") available in the HST archive for this study. From the (U-B, B-V) color-color diagram, we first estimate the total (foreground + internal) reddening toward NGC 1156 of E(B-V) =0.35 +/- 0.05 mag, whereas only the foreground reddening was previously known to be E(B-V)=0.16 mag (Burstein & Heiles) or 0.24 mag (Schlegel, Finkbeiner, & Davis). Based on the brightest stars method, selecting the three brightest blue supergiant (BSG) stars with mean B magnitude of = 21.94 mag and the three brightest red supergiant (RSG) stars with mean V magnitude of = 22.76 mag, we derive the distance modulus to NGC 1156 to be (m-M)_{0,BSG} = 29.55 mag and (m-M)_{0,RSG} = 29.16 mag. By using weights of 1 and 1.5 for the distance moduli from using the BSGs and the RSGs, respectively, we finally obtain the weighted mean distance modulus to NGC 1156 (m-M)_0 = 29.39 +/- 0.20 mag (d = 7.6 +/- 0.7 Mpc), which is in very good agreement with the previous estimates. Combining the photometry data of this study with those of Karachentsev et al. gives smaller distance to NGC 1156, which is discussed together with the limits of the data.Comment: 18 pages, 8 figures, Accepted by PASJ (2012 Apr issue

High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis

To test the carcinostatic effects of ascorbic acid, we challenged the mice of seven experimental groups with 1.7 × 10-4 mol high dose concentration ascorbic acid after intraperitoneal administrating them with sarcoma S-180 cells. The survival rate was increased by 20% in the group that received high dose concentration ascorbic acid, compared to the control. The highest survival rate was observed in the group in which 1.7 × 10-4 mol ascorbic acid had been continuously injected before and after the induction of cancer cells, rather than just after the induction of cancer cells. The expression of three angiogenesis-related genes was inhibited by 0.3 times in bFGF, 7 times in VEGF and 4 times in MMP2 of the groups with higher survival rates. Biopsy Results, gene expression studies, and wound healing analysis in vivo and in vitro suggested that the carcinostatic effect induced by high dose concentration ascorbic acid occurred through inhibition of angiogenesis

Hubble Space Telescope Pixel Analysis of the Interacting Face-on Spiral Galaxy NGC 5194 (M51A)

A pixel analysis is carried out on the interacting face-on spiral galaxy NGC 5194 (M51A), using the HST/ACS images in the F435W, F555W and F814W (BVI) bands. After 4x4 binning of the HST/ACS images to secure a sufficient signal-to-noise ratio for each pixel, we derive several quantities describing the pixel color-magnitude diagram (pCMD) of NGC 5194: blue/red color cut, red pixel sequence parameters, blue pixel sequence parameters and blue-to-red pixel ratio. The red sequence pixels are mostly older than 1 Gyr, while the blue sequence pixels are mostly younger than 1 Gyr, in their luminosity-weighted mean stellar ages. The color variation in the red pixel sequence from V = 20 mag arcsec^(-2) to V = 17 mag arcsec^(-2) corresponds to a metallicity variation of \Delta[Fe/H] ~ 2 or an optical depth variation of \Delta\tau_V ~ 4 by dust, but the actual sequence is thought to originate from the combination of those two effects. At V < 20 mag arcsec^(-2), the color variation in the blue pixel sequence corresponds to an age variation from 5 Myr to 300 Myr under the assumption of solar metallicity and \tau_V = 1. To investigate the spatial distributions of stellar populations, we divide pixel stellar populations using the pixel color-color diagram and population synthesis models. As a result, we find that the pixel population distributions across the spiral arms agree with a compressing process by spiral density waves: dense dust \rightarrow newly-formed stars. The tidal interaction between NGC 5194 and NGC 5195 appears to enhance the star formation at the tidal bridge connecting the two galaxies. We find that the pixels corresponding to the central active galactic nucleus (AGN) area of NGC 5194 show a tight sequence at the bright-end of the pCMD, which are in the region of R ~ 100 pc and may be a photometric indicator of AGN properties.Comment: 27 pages, 20 figures, accepted for publication in Ap

IS6110-Restriction Fragment Length Polymorphism and Spoligotyping Analysis of Mycobacterium tuberculosis Clinical Isolates for Investigating Epidemiologic Distribution in Korea

The Beijing family of Mycobacterium tuberculosis has been emerging in the world. However, there are few nationwide data of genotypic distribution in Korea. This study aimed to identify the genotypic diversity of clinical isolates of M. tuberculosis and to demonstrate the population of Beijing family in Korea. We collected 96 clinical M. tuberculosis isolates from 11 university hospitals nationwide in Korea from 2008 to 2009. We observed 24 clusters in IS6110-RFLP analysis and 19 patterns in spoligotyping. Seventy-five isolates were confirmed to be Beijing family. Two isolates of the K strain and 12 isolates of the K family strain were also found. We found that drug resistance phenotypes were more strongly associated with Beijing family than non-Beijing family (P=0.003). This study gives an overview of the distribution of genotypes of M. tuberculosis in Korea. These findings indicate that we have to pay more attention to control of M. tuberculosis strains associated with the Beijing family

Differences in Clinical Features According to Boryoung and Karp Genotypes of Orientia tsutsugamushi

Scrub typhus is an infectious disease caused by Orientia tsutsugamushi. The differences in virulence of O. tsutsugamushi prototypes in humans are still unknown. We investigated whether there are any differences in the clinical features of the Boryoung and Karp genotypes.Patients infected with O. tsutsugamushi, as Boryoung and Karp clusters, who had visited 6 different hospitals in southwestern Korea were prospectively compared for clinical features, complications, laboratory parameters, and treatment responses. Infected patients in the Boryoung cluster had significantly more generalized weakness, eschars, skin rashes, conjunctival injection, high albumin levels, and greater ESR and fibrinogen levels compared to the Karp cluster. The treatment response to current antibiotics was significantly slower in the Karp cluster as compared to the Boryoung cluster.The frequency of occurrence of eschars and rashes may depend on the genotype of O. tsutsugamushi

Early-type Host Galaxies of Type Ia Supernovae. II. Evidence for Luminosity Evolution in Supernova Cosmology

The most direct and strongest evidence for the presence of dark energy is provided by the measurement of galaxy distances using SNe Ia. This result is based on the assumption that the corrected brightness of SN Ia through the empirical standardization would not evolve with look-back time. Recent studies have shown, however, that the standardized brightness of SN Ia is correlated with host morphology, host mass, and local star formation rate (SFR), suggesting a possible correlation with stellar population property. To understand the origin of these correlations, we have continued our spectroscopic observations to cover most of the reported nearby early-type host galaxies. From high-quality (signal-to-noise ratio ∼175) spectra, we obtained the most direct and reliable estimates of population age and metallicity for these host galaxies. We find a significant correlation between SN luminosity (after the standardization) and stellar population age at a 99.5% confidence level. As such, this is the most direct and stringent test ever made for the luminosity evolution of SN Ia. Based on this result, we further show that the previously reported correlations with host morphology, host mass, and local SFR are most likely originated from the difference in population age. This indicates that the light-curve fitters used by the SNe Ia community are not quite capable of correcting for the population age effect, which would inevitably cause a serious systematic bias with look-back time. Notably, taken at face values, most of the Hubble residual used in the discovery of the dark energy appears to be affected by the luminosity evolution