Ethnobotanical Studies on Dental Hygiene in District Hamipur, Himachal Pradesh (H.P.), India

The present study was carried out to assess and document ethnobotanical knowledge of plants of District Hamirpur (H.P.) used for dental care, as the area has diverse flora and high ethnobotanical potential. It was found that 32 different plant species belonging to 24 families are used for dental hygiene. The studies reveal the use of 18 trees, 9 shrubs, 2 under-shrubs and 5 herbs for dental hygiene

Ethnobotanical Studies on Dental Hygiene in District Hamirpur, Himachal Pradesh (H.P.), India

The present study was carried out to assess and document ethnobotanical knowledge of plants of District Hamirpur (H.P.) used for dental care, as the area has diverse flora and high ethnobotanical potential. It was found that 32 different plant species belonging to 24 families were used for dental hygiene. The studies reveal the use of 18 trees, 9 shrubs, 2 under-shrubs and 5 herbs for dental hygiene

Crystal growth and magnetic behavior of J_eff = 1/2 quantum antiferromagnet CeCl_3

We have grown high-quality single crystals of CeCl_3 using a modified Bridgman Stockbarger method in an infrared image furnace. These crystals are characterized using single-crystal x-ray diffraction, Laue x-ray diffraction, Raman spectroscopy, magnetic susceptibility, and heat capacity probes. CeCl_3 crystallizes with a trigonal crystal structure (space group P-3, number 147). The crystal field split J = 5/2 manifold of Ce ion in CeCl_3 has an effective spin 1/2 Kramers doublet ground. The exchange coupling between the Ce moments is rather weak (Weiss temperature = 0.2 K). The magnetic susceptibility shows a broad peak centred around 50 K due to the crystal field splitting. The magnetic specific heat shows a Schottky anomaly around 30 K due to the excited crystal field doublets located near 55 K and 155 K. The Raman spectra at 300 K exhibit five, clearly resolvable, modes at 106.8, 181.2, 189, 213, and 219.7 wavenumbers.Comment: Seven figure

Complete genome sequence of Granulicella tundricola type strain MP5ACTX9T, an Acidobacteria from tundra soil

Granulicella tundricola strain MP5ACTX9(T) is a novel species of the genus Granulicella in subdivision 1 Acidobacteria. G. tundricola is a predominant member of soil bacterial communities, active at low temperatures and nutrient limiting conditions in Arctic alpine tundra. The organism is a cold-adapted acidophile and a versatile heterotroph that hydrolyzes a suite of sugars and complex polysaccharides. Genome analysis revealed metabolic versatility with genes involved in metabolism and transport of carbohydrates, including gene modules encoding for the carbohydrate-active enzyme (CAZy) families for the breakdown, utilization and biosynthesis of diverse structural and storage polysaccharides such as plant based carbon polymers. The genome of G. tundricola strain MP5ACTX9(T) consists of 4,309,151 bp of a circular chromosome and five mega plasmids with a total genome content of 5,503,984 bp. The genome comprises 4,705 protein-coding genes and 52 RNA genes

Downregulation of peripheral PTGS2/COX-2 in response to valproate treatment in patients with epilepsy

Antiepileptic drug therapy has significant inter-patient variability in response towards it. The current study aims to understand this variability at the molecular level using microarray-based analysis of peripheral blood gene expression profiles of patients receiving valproate (VA) monotherapy. Only 10 unique genes were found to be differentially expressed in VA responders (n = 15) and 6 genes in the non-responders (n = 8) (fold-change >2, p < 0.05). PTGS2 which encodes cyclooxygenase-2, COX-2, showed downregulation in the responders compared to the non-responders. PTGS2/COX-2 mRNA profiles in the two groups corresponded to their plasma profiles of the COX-2 product, prostaglandin E(2) (PGE(2)). Since COX-2 is believed to regulate P-glycoprotein (P-gp), a multidrug efflux transporter over-expressed at the blood-brain barrier (BBB) in drug-resistant epilepsy, the pathway connecting COX-2 and P-gp was further explored in vitro. Investigation of the effect of VA upon the brain endothelial cells (hCMEC/D3) in hyperexcitatory conditions confirmed suppression of COX-2-dependent P-gp upregulation by VA. Our findings suggest that COX-2 downregulation by VA may suppress seizure-mediated P-gp upregulation at the BBB leading to enhanced drug delivery to the brain in the responders. Our work provides insight into the association of peripheral PTGS2/COX-2 expression with VA efficacy and the role of COX-2 as a potential therapeutic target for developing efficacious antiepileptic treatment

Genetic landscape of common epilepsies: advancing towards precision in treatment

Epilepsy, a neurological disease characterized by recurrent seizures, is highly heterogeneous in nature. Based on the prevalence, epilepsy is classified into two types: common and rare epilepsies. Common epilepsies affecting nearly 95% people with epilepsy, comprise generalized epilepsy which encompass idiopathic generalized epilepsy like childhood absence epilepsy, juvenile myoclonic epilepsy, juvenile absence epilepsy and epilepsy with generalized tonic-clonic seizure on awakening and focal epilepsy like temporal lobe epilepsy and cryptogenic focal epilepsy. In 70% of the epilepsy cases, genetic factors are responsible either as single genetic variant in rare epilepsies or multiple genetic variants acting along with different environmental factors as in common epilepsies. Genetic testing and precision treatment have been developed for a few rare epilepsies and is lacking for common epilepsies due to their complex nature of inheritance. Precision medicine for common epilepsies require a panoramic approach that incorporates polygenic background and other non-genetic factors like microbiome, diet, age at disease onset, optimal time for treatment and other lifestyle factors which influence seizure threshold. This review aims to comprehensively present a state-of-art review of all the genes and their genetic variants that are associated with all common epilepsy subtypes. It also encompasses the basis of these genes in the epileptogenesis. Here, we discussed the current status of the common epilepsy genetics and address the clinical application so far on evidence-based markers in prognosis, diagnosis, and treatment management. In addition, we assessed the diagnostic predictability of a few genetic markers used for disease risk prediction in individuals. A combination of deeper endo-phenotyping including pharmaco-response data, electro-clinical imaging, and other clinical measurements along with genetics may be used to diagnose common epilepsies and this marks a step ahead in precision medicine in common epilepsies management

Calendario para el Reyno de Valencia...: Año 1902

Microfilme. Valencia : BV, ca. 1990Recurso electrónico. Valencia : BVNP, 20141902_A_95667

Indigenous livestock care practices in Kamlah, Mandi District, Himachal Pradesh: A preserving heritage

Cattle production has been an important source of livelihood for the rural communities. Current study aimed to documenting the indigenous traditional knowledge and practices related to livestock health care system among the people of Kamlah region of Sandhol tehsil of district Mandi (Himachal Pradesh). Reconnaissance surveys were conducted in this region from 2021 to 2022. A total of 65 informants (35 males & 30 females) were interviewed. Ethnoveterinary data was collected through semi-structured interviews and group discussions with elderly people, women, farmers and local herbal healers. In this study, 28 plant species belonging to 23 families were identified; in which herb (57%) were the maximum used life forms and leaves (43%) were the commonly used plant parts. The highest number of species recorded in families were Asparagaceae and Fabaceae (3 species each). A wide range of diseases or disorders of cattle such as bone fracture, eye infection, fever, heat stroke, insect bite, prolapsed uterus, skin disorders and stomach disorders are treated by the people of study area with the help of indigenous medicinal plants. The data was analysed using three ethnobotanical indices i.e., use value (UV), fidelity level (FL) and informant consensus factor (ICF). According to quantitative analysis, plant species with high UV values for curing live stock were Mentha spicata L. (0.92), Cassia fistula L. (0.77) and Stephania rotunda Lour. (0.77). FL% values ranged from 25 to 100% and ICF values ranged between 0.97 to 1.00. These findings were at primary level and provide basic information to the researchers for carrying out phytochemical and pharmacological investigations, to create more effective veterinary drugs

Lewis Acid Promoted Cyclization of Acyclic Urea Derivatives to Quinazolinediones

Quinazolinediones have gained special interest among researchers as they are known to have many pharmacological and medicinal uses. Here, we report an efficient way to synthesize quinazolinediones through the cyclization of acyclic ureido‐benzoate esters, catalyzed by anhydrous zinc chloride under mild conditions. A series of quinazolinediones was synthesized in good yield by reacting the corresponding ureido‐benzoate esters using this protocol. The quinazolinedione products were characterized using NMR, IR, HRMS spectroscopy and single crystal x‐ray diffraction analysis. We also present here a most plausible mechanism for the cyclization reaction