6,744 research outputs found
Effects of aortic root motion on wall stress in the Marfan aorta before and after personalised aortic root support (PEARS) surgery
Aortic root motion was previously identified as a risk factor for aortic dissection due to increased longitudinal stresses in the ascending aorta. The aim of this study was to investigate the effects of aortic root motion on wall stress and strain in the ascending aorta and evaluate changes before and after implantation of personalised external aortic root support (PEARS). Finite element (FE) models of the aortic root and thoracic aorta were developed using patient-specific geometries reconstructed from pre- and post-PEARS cardiovascular magnetic resonance (CMR) images in three Marfan patients. The wall and PEARS materials were assumed to be isotropic, incompressible and linearly elastic. A static load on the inner wall corresponding to the patients' pulse pressure was applied. Cardiovascular MR cine images were used to quantify aortic root motion, which was imposed at the aortic root boundary of the FE model, with zero-displacement constraints at the distal ends of the aortic branches and descending aorta. Measurements of the systolic downward motion of the aortic root revealed a significant reduction in the axial displacement in all three patients post-PEARS compared with its pre-PEARS counterparts. Higher longitudinal stresses were observed in the ascending aorta when compared with models without the root motion. Implantation of PEARS reduced the longitudinal stresses in the ascending aorta by up to 52%. In contrast, the circumferential stresses at the interface between the supported and unsupported aorta were increase by up to 82%. However, all peak stresses were less than half the known yield stress for the dilated thoracic aorta
Conduction velocities in amphibian skeletal muscle fibres exposed to hyperosmotic extracellular solutions
Early quantitative analyses of conduction velocities in unmyelinated nerve studied in a constantly iso-osmotic volume conductor were extended to an analysis of the effects of varying extracellular osmolarities on conduction velocities of surface membrane action potentials in Rana esculenta skeletal muscle fibres. Previous papers had reported that skeletal muscle fibres exposed to a wide range of extracellular sucrose concentrations resemble perfect osmometers with increased extracellular osmolarity proportionally decreasing fibre volume and therefore diminishing fibre radius, a. However, classical electrolyte theory (Robinson and Stokes 1959, Electrolyte solutions 2nd edn. Butterworth & Co. pp 41–42) would then predict that the consequent increases in intracellular ionic strength would correspondingly decrease sarcoplasmic resistivity, Ri. An extension of the original cable analysis then demonstrated that the latter would precisely offset its expected effect of alterations in a on the fibre axial resistance, ri, and leave action potential conduction velocity constant. In contrast, other reports (Hodgkin and Nakajima J Physiol 221:105–120, 1972) had suggested that Riincreased with extracellular osmolarity, owing to alterations in cytosolic viscosity. This led to a prediction of a decreased conduction velocity. These opposing hypotheses were then tested in muscle fibres subject to just-suprathreshold stimulation at a Vaseline seal at one end and measuring action potentials and their first order derivatives, dV/dt, using 5–20 MΩ, 3 M KCl glass microelectrodes at defined distances away from the stimulus sites. Exposures to hyperosmotic, sucrose-containing, Ringer solutions then reversibly reduced both conduction velocity and maximum values of dV/dt. This was compatible with an increase in Ri in the event that conduction depended upon a discharge of membrane capacitance by propagating local circuit currents through initially passive electrical elements. Conduction velocity then showed graded decreases with increasing extracellular osmolarity from 250–750 mOsm. Action potential waveforms through these osmolarity changes remained similar, including both early surface and the late after-depolarisation events reflecting transverse tubular activation. Quantitative comparisons of reduced-χ 2 values derived from a comparison of these results and the differing predictions from the two hypotheses strongly favoured the hypothesis in which Riincreased rather than decreased with hyperosmolarity
Takotsubo cardiomyopathy and sepsis: a systematic review
Takotsubo cardiomyopathy (TTC) is characterized by a systolic dysfunction localized in the apical and medial aspect of
the left ventricle. It is usually related to physical or emotional stress. Recent evidence highlighting the role of infection
led us to analyze the links between TTC and sepsis. A systematic review of the literature was undertaken to assess any
trends in clinical findings, diagnosis, and outcomes in such patients. We identified 23 selected papers reporting a total of
26 patients, having sepsis, in whom TTC occurred. For each case, we collected data identifying population characteristics,
source of sepsis, clinical disease description, and the results of cardiovascular investigations. The majority of patients
were females (n = 16), mean age was 62.8 (14.0 standard deviation) years, and clinical outcome was favorable in 92.3% of
the cases once the management of sepsis was initiated. A better understanding of the mechanisms of sepsis-associated
TTC may generate novel strategies to treat the complications of this cardiomyopathy and may even help predict and
prevent its occurrence
Kolmogorov scaling and intermittency in Rayleigh-Taylor turbulence
The Rayleigh--Taylor (RT) turbulence is investigated by means of high
resolution numerical simulations. The main question addressed here is on
whether RT phenomenology can be considered as a manifestation of universality
of Navier--Stokes equations with respect to forcing mechanisms. At a
theoretical level the situation is far from being firmly established and,
indeed, contrasting predictions have been formulated. Our first aim here is to
clarify the above controversy through a deep analysis of scaling behavior of
relevant statistical observables. The effects of intermittency on the mean
field scaling predictions is also discussed.Comment: 4 pages, 5 figure
Carbon-fiber tips for scanning probe microscopes and molecular electronics experiments
We fabricate and characterize carbon-fiber tips for their use in combined
scanning tunneling and force microscopy based on piezoelectric quartz tuning
fork force sensors. An electrochemical fabrication procedure to etch the tips
is used to yield reproducible sub-100-nm apex. We also study electron transport
through single-molecule junctions formed by a single octanethiol molecule
bonded by the thiol anchoring group to a gold electrode and linked to a carbon
tip by the methyl group. We observe the presence of conductance plateaus during
the stretching of the molecular bridge, which is the signature of the formation
of a molecular junction.Comment: Conference Proceeding (Trends in NanoTechnology 2011, Tenerife
SPAIN); Nanoscale Research Letters, (2012) 7:25
Comets, historical records and vedic literature
A verse in book I of Rigveda mentions a cosmic tree with rope-like aerial
roots held up in the sky. Such an imagery might have ensued from the appearance
of a comet having `tree stem' like tail, with branched out portions resembling
aerial roots. Interestingly enough, a comet referred to as `heavenly tree' was
seen in 162 BC, as reported by old Chinese records. Because of weak surface
gravity, cometary appendages may possibly assume strange shapes depending on
factors like rotation, structure and composition of the comet as well as solar
wind pattern. Varahamihira and Ballala Sena listed several comets having
strange forms as reported originally by ancient seers such as Parashara,
Vriddha Garga, Narada and Garga.
Mahabharata speaks of a mortal king Nahusha who ruled the heavens when Indra,
king of gods, went into hiding. Nahusha became luminous and egoistic after
absorbing radiance from gods and seers. When he kicked Agastya (southern star
Canopus), the latter cursed him to become a serpent and fall from the sky. We
posit arguments to surmise that this Mahabharata lore is a mythical recounting
of a cometary event wherein a comet crossed Ursa Major, moved southwards with
an elongated tail in the direction of Canopus and eventually went out of sight.
In order to check whether such a conjecture is feasible, a preliminary list of
comets (that could have or did come close to Canopus) drawn from various
historical records is presented and discussed.Comment: This work was presented in the International Conference on Oriental
Astronomy held at IISER, Pune (India) during November, 201
Coherent quantum state storage and transfer between two phase qubits via a resonant cavity
A network of quantum-mechanical systems showing long lived phase coherence of
its quantum states could be used for processing quantum information. As with
classical information processing, a quantum processor requires information bits
(qubits) that can be independently addressed and read out, long-term memory
elements to store arbitrary quantum states, and the ability to transfer quantum
information through a coherent communication bus accessible to a large number
of qubits. Superconducting qubits made with scalable microfabrication
techniques are a promising candidate for the realization of a large scale
quantum information processor. Although these systems have successfully passed
tests of coherent coupling for up to four qubits, communication of individual
quantum states between qubits via a quantum bus has not yet been demonstrated.
Here, we perform an experiment demonstrating the ability to coherently transfer
quantum states between two superconducting Josephson phase qubits through a
rudimentary quantum bus formed by a single, on chip, superconducting
transmission line resonant cavity of length 7 mm. After preparing an initial
quantum state with the first qubit, this quantum information is transferred and
stored as a nonclassical photon state of the resonant cavity, then retrieved at
a later time by the second qubit connected to the opposite end of the cavity.
Beyond simple communication, these results suggest that a high quality factor
superconducting cavity could also function as a long term memory element. The
basic architecture presented here is scalable, offering the possibility for the
coherent communication between a large number of superconducting qubits.Comment: 17 pages, 4 figures (to appear in Nature
A hysteretic multiscale formulation for nonlinear dynamic analysis of composite materials
This article has been made available through the Brunel Open Access Publishing Fund.A new multiscale finite element formulation
is presented for nonlinear dynamic analysis of heterogeneous
structures. The proposed multiscale approach utilizes
the hysteretic finite element method to model the microstructure.
Using the proposed computational scheme, the micro-basis functions, that are used to map the microdisplacement components to the coarse mesh, are only evaluated once and remain constant throughout the analysis procedure. This is accomplished by treating inelasticity at the micro-elemental level through properly defined hysteretic evolution equations. Two types of imposed boundary conditions are considered for the derivation of the multiscale basis functions, namely the linear and periodic boundary conditions. The validity of the proposed formulation as well as its computational efficiency are verified through illustrative numerical experiments
A Regularized Graph Layout Framework for Dynamic Network Visualization
Many real-world networks, including social and information networks, are
dynamic structures that evolve over time. Such dynamic networks are typically
visualized using a sequence of static graph layouts. In addition to providing a
visual representation of the network structure at each time step, the sequence
should preserve the mental map between layouts of consecutive time steps to
allow a human to interpret the temporal evolution of the network. In this
paper, we propose a framework for dynamic network visualization in the on-line
setting where only present and past graph snapshots are available to create the
present layout. The proposed framework creates regularized graph layouts by
augmenting the cost function of a static graph layout algorithm with a grouping
penalty, which discourages nodes from deviating too far from other nodes
belonging to the same group, and a temporal penalty, which discourages large
node movements between consecutive time steps. The penalties increase the
stability of the layout sequence, thus preserving the mental map. We introduce
two dynamic layout algorithms within the proposed framework, namely dynamic
multidimensional scaling (DMDS) and dynamic graph Laplacian layout (DGLL). We
apply these algorithms on several data sets to illustrate the importance of
both grouping and temporal regularization for producing interpretable
visualizations of dynamic networks.Comment: To appear in Data Mining and Knowledge Discovery, supporting material
(animations and MATLAB toolbox) available at
http://tbayes.eecs.umich.edu/xukevin/visualization_dmkd_201
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