7 research outputs found
Genetic parameters for body weight, reproduction, and parasite resistance traits in the Creole goat1
Carcass conformation and description of Creole goat of Guadeloupe : Initial results
International audienc
Genetic variability in resistance to gastro-intestinal strongyles during early lactation in Creole goats
Effect of changes in the nutritional status on the performances of growing Creole kids during an established nematode parasite infection
Mortality of Creole kids during infection with gastrointestinal strongyles: A survival analysis1
Economic values of body weight, reproduction and parasite resistance traits for a Creole goat breeding goal
VarGoats project: a dataset of 1159 whole-genome sequences to dissect Capra hircus global diversity
International audienceBackground Since their domestication 10,500 years ago, goat populations with distinctive genetic backgrounds have adapted to a broad variety of environments and breeding conditions. The VarGoats project is an international 1000-genome resequencing program designed to understand the consequences of domestication and breeding on the genetic diversity of domestic goats and to elucidate how speciation and hybridization have modeled the genomes of a set of species representative of the genus Capra . Findings A dataset comprising 652 sequenced goats and 507 public goat sequences, including 35 animals representing eight wild species, has been collected worldwide. We identified 74,274,427 single nucleotide polymorphisms (SNPs) and 13,607,850 insertion-deletions (InDels) by aligning these sequences to the latest version of the goat reference genome (ARS1). A Neighbor-joining tree based on Reynolds genetic distances showed that goats from Africa, Asia and Europe tend to group into independent clusters. Because goat breeds from Oceania and Caribbean (Creole) all derive from imported animals, they are distributed along the tree according to their ancestral geographic origin. Conclusions We report on an unprecedented international effort to characterize the genome-wide diversity of domestic goats. This large range of sequenced individuals represents a unique opportunity to ascertain how the demographic and selection processes associated with post-domestication history have shaped the diversity of this species. Data generated for the project will also be extremely useful to identify deleterious mutations and polymorphisms with causal effects on complex traits, and thus will contribute to new knowledge that could be used in genomic prediction and genome-wide association studies