Optimizing Guideline-Recommended Antibiotic Doses for Pediatric Infective Endocarditis

The American Heart Association recently published an updated scientific statement on the management of infective endocarditis in childhood. The recommendations included for vancomycin, aminoglycoside, and β-lactam dosing and monitoring are based primarily on expert opinion and do not consider available evidence for dose optimization based on pharmacokinetic and pharmacodynamic principles in pediatric patients. This is concerning because even when clinically necessary, some practitioners may be hesitant to deviate from guideline-recommended doses. In this perspective, we highlight potential areas for improvement in the statement-recommended doses and summarize evidence supporting antibiotic dosing optimization. The addition of a pediatric clinical pharmacist with expertise in antibiotic dosing to the panel would be beneficial for future updates

Next generation sequencing analysis reveals a relationship between rDNA unit diversity and locus number in Nicotiana diploids

© 2012 Matyášek et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Equivalences between spin models induced by defects

The spectrum of integrable spin chains are shown to be independent of the ordering of their spins. As an application we introduce defects (local spin inhomogeneities in homogenous chains) in two-boundary spin systems and, by changing their locations, we show the spectral equivalence of different boundary conditions. In particular we relate certain nondiagonal boundary conditions to diagonal ones.Comment: 14 pages, 16 figures, LaTeX, Extended versio

Structure of the two-boundary XXZ model with non-diagonal boundary terms

We study the integrable XXZ model with general non-diagonal boundary terms at both ends. The Hamiltonian is considered in terms of a two boundary extension of the Temperley-Lieb algebra. We use a basis that diagonalizes a conserved charge in the one-boundary case. The action of the second boundary generator on this space is computed. For the L-site chain and generic values of the parameters we have an irreducible space of dimension 2^L. However at certain critical points there exists a smaller irreducible subspace that is invariant under the action of all the bulk and boundary generators. These are precisely the points at which Bethe Ansatz equations have been formulated. We compute the dimension of the invariant subspace at each critical point and show that it agrees with the splitting of eigenvalues, found numerically, between the two Bethe Ansatz equations.Comment: 9 pages Latex. Minor correction

Self-organized metal nanostructures through laser driven thermocapillary convection

When ultrathin metal films are subjected to multiple cycles of rapid melting and resolidification by a ns pulsed laser, spatially correlated interfacial nanostructures can result from a competition among several possible thin film self-organizing processes. Here we investigate self-organization and the ensuing length scales when Co films (1-8 nm thick) on SiO_{\text{2}} surfaces are repeatedly and rapidly melted by non-uniform (interference) laser irradiation. Pattern evolution produces nanowires, which eventually break-up into nanoparticles exhibiting spatial order in the nearest neighbor spacing, \lambda_{NN2}.The scaling behavior is consistent with pattern formation by thermocapillary flow and a Rayleigh-like instability. For h_{0}\leq2 nm, a hydrodynamic instability of a spinodally unstable film leads to the formation of nanoparticles.Comment: 10 pages, 3 figure

Application of LANDSAT-2 data to the implementation and enforcement of the Pennsylvania Surface Mining Conservation and Reclamation Act

The author has identified the following significant results. Evaluation of LANDSAT imagery indicates severe limitations in its utility for surface mine land studies. Image stripping resulting from unequal detector response on satellite degrades the image quality to the extent that images of scales larger than 1:125,000 are of limited value for manual interpretation. Computer processing of LANDSAT data to improve image quality is essential; the removal of scanline stripping and enhancement of mine land reflectance data combined with color composite printing permits useful photographic enlargements to approximately 1:60,000

Supporting the active learning of collaborative database browsing techniques

We describe the implications of a study of database browsing behaviour for the development of a system to support more effective browsing. In particular we consider the importance of collaborative working, both in learning browsing skills and in co‐operating on a shared information‐retrieval task. From our study, we believe that an interface to support collaboration should promote the awareness of the activities of others, better visualization of the information data structures being browsed, and effective communication of the browsing process