Outcome of children with panarteritis nodosa: a series of 30 cases

International audiencepas de résum

PReS-FINAL-2161: Safety and effectiveness of adalimumab in children with polyarticular juvenile idiopathic arthritis aged 2 to <4 years or >=4 years weighing <15 kg

International audienceEn faisant le tour du monde (Mauritanie, Madagascar, Éthiopie, Burkina Faso, Cameroun, New-York, Nouvelle-Zélande, France... ) en passant par l’Internet, cet ouvrage fait le point sur les dernières innovations en matière de gestion des déchets. Considéré comme une ressource, le déchet révèle enfin sa valeur : il est créateur de revenus, de liens sociaux et de nouvelles technologies. C’est pourquoi il devient urgent de structurer son économie

Patterns and determinants of response to novel therapies in juvenile and adult-onset polyarthritis

Biological and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) have revolutionized the management of multiple rheumatic inflammatory conditions. Amongst these, polyarticular Juvenile-Idiopathic Arthritis (pJIA) and Rheumatoid Arthritis (RA) display similarities in terms of disease pathophysiology and response pattern to b/tsDMARDs. Indeed, therapeutic efficacy of novel targeted drugs is variable among individual patients, in both RA and pJIA. Mechanisms and determinants of this heterogeneous response are diverse and complex, such that development of true “precision”-medicine strategies has proven highly challenging. In this review, we will discuss pathophysiological, patient-specific, drug-specific and environmental factors contributing to individual therapeutic response in polyarticular JIA in comparison to what is known in RA. Although some biomarkers have been identified that stratify for the likelihood of either therapeutic response or non-response, few have proved useful in clinical practice so far, likely due to the complexity of treatment-response mechanisms. Consequently, we propose a pragmatic, patient-centered and clinically-based approach, i.e. personalized instead of biomarker-based precision medicine in JIA

Multiscale Analysis of the Stress State in a Granular Slope in Transition to Failure

By means of contact dynamics simulations, we analyze the stress state in a granular bed slowly tilted towards its angle of repose. An increasingly large number of grains are overloaded in the sense that they are found to carry a stress ratio above the Coulomb yield threshold of the whole packing. Using this property, we introduce a coarse-graining length scale at which all stress ratios are below the packing yield threshold. We show that this length increases with the slope angle and jumps to a length comparable to the depth of the granular bed at an angle below the angle of repose. This transition coincides with the onset of dilatation in the packing. We map this transition into a percolation transition of the overloaded grains, and we argue that in the presence of long-range correlations above the transition angle, the granular slope is metastable.Comment: 11 pages, 14 Fig, submitted to PR