Removal of ocular artifacts from EEG signals using adaptive threshold PCA and Wavelet transforms

It becomes more difficult to identify and analyze the Electroencephalogram (EEG) signals when it is corrupted by eye movements and eye blinks. This paper gives the different methods how to remove the artifacts in EEG signals. In this paper we proposed wavelet based threshold method and Principal Component Analysis (PCA) based adaptive threshold method to remove the ocular artifacts. Compared to the wavelet threshold method PCA based adaptive threshold method will gives the better PSNR value and it will decreases the elapsed time

Biocatalytic route to C-3?-azido/-hydroxy-C-4?-spiro-oxetanoribonucleosides

The lipase, Novozyme®-435, exclusively deacetylates the 5-O-acetyl over 4-C-acetyloxymethyl group of almost identical reactivity in 5-O-acetyl-4-C-acetyloxymethyl-3-azido-3-deoxy-1,2-O-isopropylidene-?-D-ribofuranose that led to the development of first and efficient synthesis of 3?-azido-/3?-amino-C-4?-spiro-oxetanoribonucleosides T, U, C and A in 20–24% overall yields. The X-ray study on the compound obtained by tosylation of lipase-mediated monodeacetylated product unambiguously confirmed the point of diastereoselective monodeacetylation on diacetoxy-azido-ribofuranose derivative. The capability of Novozyme®-435 for selective deacylation of 5-O-acetyl group in 5-O-acetyl-4-C-acetyloxymethyl-3-O-benzyl-1,2-O-isopropylidene-?-D-ribofuranose recently discovered by us has been successfully used for the synthesis of C-4?-spiro-oxetanoribonucleosides A and C in good yields. These results clearly indicate that the broader substrate specificity and highly selective capability of Novozyme®-435 for carrying out acetylation/deacetylation reactions can be utilized for the development of environment friendly selective methodologies in organic synthesis

Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins

In the last decades, various efforts have been made to synthesize optimal glycotripods for targeting trimeric glycoproteins like asialoglycoprotein receptor, hemagglutinin, and langerin. All these trimeric glycoproteins have sugar binding pockets which are highly selective for a particular carbohydrate ligand. Optimized glycotripods are high affinity binders and have been used for delivering drugs or even applied as drug candidates. The selection of the tripodal base scaffold together with the length and flexibility of the linker between the scaffold and sugar residue, as important design parameters are discussed in this review

Effect of Lutein in the expression of PPARα and LDLR in hypercholesterolemic male Wistar Rats

Background: Hyperlipidemia is a well known risk factor for cardiovascular disease, especially atherosclerotic coronary artery disease. Peroxisome proliferator activated receptor α (PPARα), a member of this nuclear receptor family, has emerged as an important player in this scenario, with evidence supporting a central co-ordinated role in the regulation of fatty acid oxidation, lipid and lipoprotein metabolism and inflammatory and vascular responses, all of which would be predicted to reduce atherosclerotic risk. The low-density lipoprotein (LDL) receptor (LDLR) is the primary pathway for removal of cholesterol from the circulation, and its activity is meticulously governed by intracellular cholesterol levels. Hence in this study we investigated the effect of Lutein on PPARα and LDLR expression in liver of wistar rats.Methods: Male Wistar rats were divided into 6 groups of 6 each. Group I served as control. Group II III, IV, V and VI rats were received high cholesterol diet. Group III was treated with Atorvastatin 5mg/kg. Group IV, V and VI rats were treated with 25mg/kg, 50mg/kg and 100mg/kg of Lutein. After 16 weeks, liver tissue samples were collected from all the groups of animals to evaluate the expression of PPARα and LDLR.Results: The expression of Peroxisome proliferator activated receptor α and low-density lipoprotein (LDL) receptor (LDLR) was significantly increased in Lutein treated hypercholesterolemic male wistar rats.Conclusions: The results of this study indicate that Lutein activates LDL receptor and PPARα in hypercholesterolemic male wistar rats

Role of Nasal Endoscopy in Chronic Osteomyelitis of Maxilla and Zygoma: A Case Report

Osteomyelitis of the jaws was relatively common before the era of antibiotic therapy and preventive and restorative dentistry. Osteomyelitis is an acute or chronic inflammatory process that can involve cortical and trabecular aspects of bone or bone marrow. Cranial bones are infrequently involved, but spreading of inflammation with involvement of surrounding structures represents important risk, such as cerebral abscess, encephalitis, or meningitis. The mandible is more commonly involved than the maxilla. Dentogenic infections cause 38% of mandibular and 25% of maxillary involvement. Involvement of zygoma is very rare. Factors like viral fevers, malnutrition, malaria, anemia,tobacco chewing, immunodeficiency, osteopetrosis, Paget's disease of bone, and florid cemento-osseous dysplasia (FCOD) result in decreased vascularity of the affected bone, predisposing to the development of osteomyelitis. We present a case of osteomyelitis of left maxilla and zygoma with oroantral fistula in an immunocompetent adult male caused by dentogenic infection. The complete resolution of infection was gained with surgical treatment using nasal endoscope and antibiotic therapy. The aims of this paper are to illustrate diagnostic patterns, to report radiographic findings and surgical treatment using nasal endoscope in a case of osteomyelitis of maxilla and zygoma. The prognosis and cosmetic results are discussed

Melting of Major Glaciers in Himalayas: Role of Desert Dust and Anthropogenic Aerosols

The Himalayan and Tibet Glaciers, that are among the largest bodies of ice and fresh water resource outside of the polar ice caps, face a significant threat of accelerated meltdown in coming decades due to climate variability and change. The rate of retreat of these glaciers and changes in their terminus (frontal dynamics) is highly variable across the Himalayan range. These large freshwater sources are critical to human activities for food production, human consumption and a whole host of other applications, especially over the Indo-Gangetic (IG) plains. They are also situated in a geo-politically sensitive area surrounded by China, India, Pakistan, Nepal and Bhutan where more than a billion people depend on them. The major rivers of the Asian continent such as the Ganga (also known as Ganges), Brahmaputra, Indus, Yamuna, Sutluj etc., originate and pass through these regions and they have greater importance due to their multi-use downstream: hydro power, agriculture, aquaculture, flood control, and as a freshwater resource. Recent studies over the Himalayan Glaciers using ground-based and space-based observations, and computer models indicate a long-term trend of climate variability and change that may accelerate melting of the Himalayan Glaciers.https://digitalcommons.chapman.edu/sees_books/1001/thumbnail.jp

Concurrent Development and Certification of SOFTCOMAG 49AA Alloy for Aeronautical Applications

Softcomag 49AA alloy consisting of 49 wt per cent Fe, 49 wt. per cent Co and 2 wt per cent V is a soft magnetic alloy with a combination of very high saturation magnetisation and high magnetostriction and used for several aeronautical applications such as generators (stators and rotors), fixed iron moving armature units etc. Though this alloy is brittle in nature, it can be formed into hot rolled bars and cold rolled sheets by adopting suitable thermo mechanical treatments. In order to indigenise and subsequent type certification for aeronautical applications, the alloy was produced using 100 per cent virgin raw materials in a vacuum induction melting (VIM) furnace which not only ensures substantial reduction of inclusions, but also the production of homogeneous alloy as a result of induction stirring. The chemical composition was examined and hot working parameters of the alloy were so optimised that they would result in the best combination of magnetic, physical and mechanical properties for the end use, which forms the central theme behind the developmental activity that was simultaneously covered by a comprehensive certification process. The material thus produced is subjected to stringent quality control checks in accordance with stipulated airworthiness norms. The paper discusses in detail the indigenisation efforts and airworthiness certification of the alloy Softcomag 49AA and its comparison with equivalent grades, namely PERMENDUR 49 and VACOFLUX 50.Defence Science Journal, 2012, 62(1), pp.67-72, DOI:http://dx.doi.org/10.14429/dsj.62.1093

Lewis acid promoted synthesis of methylene-bridged α-and γ-bis-benzopyrones

43-50The Lewis acid promoted Fries rearrangement of O-methoxyacetyl derivatives of hydroxy-chromanones, coumarins and chromones under solvent-free condition gives isomeric methylene-bridged bischromanones, biscoumarins and bischromones, respectively, in good yields. The benzopyrone precursors undergo intermolecular rearrangement wherein two benzopyrone moieties are joined through their benzene rings via an un-substituted methylene bridge