The Bergman-Fridman invariant on some classes of pseudoconvex domains

We study the boundary behaviour of a variant of the Fridman's invariant function (defined in terms of the Bergman metric) on Levi corank one domains, strongly pseudoconvex domains, smoothly bounded convex domains in $\mathbb{C}^n$ and polyhedral domains in $\mathbb{C}^2$

Case Report on Conjunctivitis an Outbreak Disease in Dehradun India

On July, 2023, the head of a GDMC, Dehradun similar eye symptoms among the students. We investigated the cluster to confirm the diagnosis, identify potential exposures, and propose recommendations. We defined a case as redness/watering/discharge from any eye among the students15 July, 2023 to 20 august 2023. We actively searched for the cases and calculated attack rates. We drew epicurve by date of symptoms onset. We conducted a Prospective cohort study of students and staff. We collected data on potential exposures and calculated Risk Ratio (RR), 95% Confidence Interval (95%CI), and Population Attributable Risk (PAR)

Synthesis Approach of 2D Mesh Network Inter Communication (2D-2D) using Network on Chip

The solution for the multiprocessor system architecture is Application specific Network on Chip (NOC) architectures which are emerging as a leading technology. Modeling and simulation of multilevel network structure and synthesis for custom NOC can beneficial in addressing several requirements such as bandwidth, inter process communication, multitasking application use, deadlock avoidance, router structures and port bandwidth. The paper emphasizes on the network on chip modeling and synthesis of 2D network and intercommunication among multilevel 2D networks. NOC synthesis environment provides transaction level network modeling and address all the requirements together in an integrated chip. In the paper consideration is done for 2D, 8 x 8 network and similar networks are considered which are identified by their specific network address. NOC chip is developed using VHDL programming language. Design is implemented in Xilinx 14.2 VHDL software, functional simulation is carried out in Modelsim 10.1 b, student edition and synthesis process is carried out on Digilent Sparten -3E FPGA

Randomized Phase III Trial Comparing Epirubicin/ Doxorubicin Plus Docetaxel and Epirubicin/ Doxorubicin Plus Paclitaxel as First Line Treatment in Women with Advanced Breast Cancer

This study aimed to examine the efficacy of docetaxel plus epirubicin against docetaxel plus capecitabine as first-line therapy for women with advanced breast cancer (ABC). Patients with ABC who had not been treated in the past were split into two groups: those who received docetaxel and epirubicin (DE) on day 1 and those who received docetaxel and capecitabine (DC) on day 1 and twice daily on days 1-14 of each 21-day cycle. Prior neoadjuvant treatment with anthracyclines was permitted if it had been finished more than a year prior to enrolment. The study\u27s major aim was to evaluate the difference in time to disease progression (TTP). Median TTP for DE was 10.6 months and for DC it was 11.0 months (P = 0.7), with each arm treating 170 women. Using the RECIST criterion, we found that the rates of complete responses were higher in DC (61%) than in DE (11%), and that the rates of partial responses were lower in DC (40%) than in DE (45%) (P = 0.8). Grade 3-4 neutropenia was more common with DE than DC (57% vs. 46%, P = 0.07), as were febrile neutropenia (11% vs. 8%, P = 0.4), hand-foot syndrome (0% vs. 4%, P = 0.02), grade 2-3 anemia (20% vs. 7%, P = 0.001), and asthenia (12% vs. 6%, P = 0.09)

Combine Therapy of Gallic Acid and Allicin in Management of Diabetes

Type 2 diabetes, also known (DM) is a metabolic disorder with a high mortality and disability incidence. The development and activation of oxidative stress (OS) are crucial to the pathogenic development of DM. Pathophysiological evidence suggests that OS contributes to the onset and progression of DM through its association with hyperglycemia, resistance to insulin, and inflammation. It\u27s worth noting that more and more studies are investigating the benefits of natural antioxidants for managing DM. Many different types of culinary and herbal plants contain the antioxidant and anti-inflammatory compounds gallic acid (GA) and allicin, respectively. The synthesis of advanced glycation end products (AGEs) is inhibited, fat is stored less, blood sugar and weight are improved, and the body produces fewer AGEs, according to the study\u27s authors. Inhibition of RAGEs and prevention of AGE activity following treatment with GA and allicin resulted in reduced oxidative stress and enhanced insulin secretion. The goals of this article are to (1) provide evidence that GA and allicin may be effective antihyperglycemic treatments for DM and its complications and (2) provide a comprehensive review of the current state of knowledge regarding studies examining the role of oleic acid in this disease

Effect of UV-B radiations on mortality and enzymes level in fish larvae of Tor tor and Schizothorax richardsonii on laboratory scale

Depletion of stratospheric ozone layer is resulting into increase in solar UV-B on earth surface. Ultra violet radiation is well known to cause many detrimental effects in aquatic organisms. The present study was performed to study the effect of solar ultraviolet radiation on fish fingerlings of Tor tor and Schizothorax richardsonii as a model system on laboratory scale. The effect of different intensities of natural solar and artificial UV-B radiation on fish larvae of T. tor and S. richardsonii in a presence of retene was investigated. Solar ultraviolet intensity showed seasonal and altitudinal variations in Garhwal region. Solar UV radiation level was lower (0.390 mw/cm2) in the month of January- February at lower altitude and highest (1.192 mw/cm2) in the month of July-August 2018 at higher altitude. Fish larvae exposed to artificial UV-B (average wavelength 312 nm and intensity of 750 mw/cm2) with retene (50µg/l) showed increase in gills malandialdehyde level and caused larvae mortality as indicating that enhanced solar UV-B exposure could be lethal to fish fauna in aquatic ecosystem. Artificial UV-B had a stronger damaging effect on fish larvae than solar radiation exhibited highly toxic in presence of retene. The larvae of S. richardsonii was found more sensitive than T. tor as indicated by high mortality rate (30%) and high pigmented characteristics on dorsal side. The solar and ultraviolet radiation showed a positive effect on high pigmentation. These results suggest that on a short time scale, UV-B radiation causing developmental stress on fish larvae may contribute to assess the phototoxic behaviour of cold water fishes

Mathematically optimized production, purification and characterization of penicillin G acylase from soil bacterial isolates AA17A and AA17B

260-268This research article deals with production of industrial enzyme penicillin G acylase from soil bacterial isolates namely AA17A and AA17B, which are selected from 80 soil samples. The strains were selected based on qualitative (turbidity) and quantitative (HPLC) test for 6-aminopenicillanic acid (6APA) production. The enzyme was assayed for its activity and optimized for production of enzyme using design of experiments software (DOE) “Design Expert 8.0.7.1”. Optimization of enzyme production of four carbon sources (glucose, glycerol, sucrose and starch), four nitrogen sources (beef extract, tryptone, peptone and yeast extract), for temperature (25°C, 30°C, 35°C and 40°C), four pH (6, 7, 8, 9), four inoculum volumes (2.5 ml, 5.0 ml, 7.5 ml, 10.0 ml) and the phenyl acetic acid (PAA) level  (0.15%, 0.17%, 0.185%, 0.2%). The penicillin acylase activity was enhanced to 1.2 fold under following optimized culture conditions: carbon source - glucose (8%), nitrogen source - beef extract (2%), pH 9.0, temperature 30ºC, phenyl acetic acid 0.185%, inoculum volume 5 ml. Approximately 1.22-fold purification from the initial culture broth was achieved during ammonium sulphate precipitation (70-80%) with a yield of 4.6% enzyme. The specific activity of the final partially purified enzyme was 13.73 IU/mg protein

Contraceptive practices and awareness about emergency contraception among women attending a tertiary care hospital of Delhi, India

Background: Emergency contraceptive pills (ECs) are a safe female-controlled method of post-coital contraception; however, the knowledge about them is low among general population.Methods: This cross-sectional study was done among the adult females, aged 18 years and above, who visited the various out-patient departments (OPD) of a tertiary care hospital in July 2017. A total of 640 adult females, who visited the OPDs of medicine, surgery, orthopedics and gynecology were included in this study. Data were entered and analyzed using SPSS ver 16. Chi-square test was used to test association. A p-value of less than 0.05 was considered as significant association.Results: Of the 640 participants, mostly were Hindu, aged between 20-29 years, married and had more than one child. Only, 52% females were aware of the term ‘contraception’ and 17.7% about ‘emergency contraception’. The only method of ECs they were aware of was i-pill. Commonest source of their knowledge was friends, relatives and spouse. Only 70 women knew that it can be used after unprotected intercourse and 25 knew that it can be used after failure of barrier method. Just 41.2% women used any kind of contraceptive and 5.3% women have ever used an EC. Around 28% women reported not using contraception due to lack of knowledge.Conclusions: Despite of their availability since many years, awareness about emergency contraception is low. More efforts are required to generate awareness about regular use of effective contraception and emergency contraception if required

A Brief Description of Different Types of Cancers and Role of Some Herbs & Bioactive Compounds in Lung Cancer Management

Cancer immunotherapy has considerably raised patient survival rates and significantly improved patients\u27 quality of life in comparison to the gold standard of care, which includes chemotherapy, radiation therapy, and surgery. Immunotherapy has firmly established itself as a novel pillar of cancer care across the board, from the metastatic stage all the way through adjuvant and neoadjuvant treatment in a wide variety of cancer types. In this overview, the primary emphasis will be placed on the seminal moments in the history of cancer immunotherapy that prepared the way for the cutting-edge treatments that are available today. Cancer treatment that makes use of medicinal herbs and the phytocompounds that can be obtained from those herbs is becoming an increasingly attractive option. It has been demonstrated in a number of clinical studies that the use of herbal medicines in conjunction with conventional therapy can increase survival rates, immunological modulation, and quality of life (QOL) in patients who have cancer. In addition to this, we highlight the challenges and restrictions currently faced by cancer checkpoint immunotherapy as well as the cutting-edge research being conducted in the fields of individualized cancer vaccines, autoimmunity, the microbiome, the microenvironment of tumors, and metabolomics to find solutions to these problems. For hundreds of years, practitioners of traditional medicine have depended on treatments derived from plants. Many studies on their use have been carried out all over the world, and some of the findings have led to the development of medicines that are derived from plants. The global market for medicinal plant products is estimated to be worth more than one hundred billion dollars each year. This research investigates the role, contributions, and utility of medicinal plants in the context of the current strategic methods to disease prevention, notably lung cancer, which is a public health concern. The focus of this research is on the current strategic approaches to disease prevention

PHARMACOGNOSTIC AND PHARMACOLOGICAL ASPECT OF BACOPA MONNIERI - A REVIEW

It is said that the use of Bacopa monnieri for memory enhancement goes back 3000 years or more in India, when it was cited for its medicinal properties, especially the memory enhancing capacity, in the Vedic texts "Athar-Ved Samhila" (3:1) of 800 B.C. and in Ayurveda. In the folklore of Indian medicine, several herbs have been used traditionally as brain or nerve tonics. One of the most popular of these neurotonics is Bacopa monnieri, a well known memory booster. Brahmi has been administered at religious institutions to help students to enhance their memory for learning ancient, religious hymns.It is also used as cardio-tonic, tranquilizer and sedative, improves process of learning, Restores memory, enhances power of speech and imagination, diuretic and nervine tonic, anti stress, for nervous and mental strain, use in insanity, epilepsy, hysteria, aesthenia, nervous breakdown. It is a small, creeping succulent herb. The leaf and flower bearing stems are 10- 30 cm long and arise from creeping stems that form roots at the nodes with pale blue or pinkish white flowers belonging to  Family  Scrophulariaceae grown nearly banks of freshwater streams and ponds, paddy fields and other damp places. The chief Phyto-constituents present are brahmine, herpestine, alkaloids and saponins. Keywords: Ayurveda, Brahmi, memory booster, herb, neurotonics, tranquilizer.Â